Search Results - "Monteiro, Diana C.F."

Structural Kinetics of MsbA Investigated by Stopped-Flow Time-Resolved Small-Angle X-Ray Scattering by Josts, Inokentijs, Gao, Yunyun, Monteiro, Diana C.F., Niebling, Stephan, Nitsche, Julius, Veith, Katharina, Gräwert, Tobias W., Blanchet, Clement E., Schroer, Martin A., Huse, Nils, Pearson, Arwen R., Svergun, Dmitri I., Tidow, Henning

“…Recent structures of full-length ATP-binding cassette (ABC) transporter MsbA in different states indicate large conformational changes during the reaction…”
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A cryo-EM grid preparation device for time-resolved structural studies by Kontziampasis, Dimitrios, Klebl, David P, Iadanza, Matthew G, Scarff, Charlotte A, Kopf, Florian, Sobott, Frank, Monteiro, Diana C F, Trebbin, Martin, Muench, Stephen P, White, Howard D

“…Structural biology generally provides static snapshots of protein conformations that can provide information on the functional mechanisms of biological…”
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The Structure of the PanD/PanZ Protein Complex Reveals Negative Feedback Regulation of Pantothenate Biosynthesis by Coenzyme A by Monteiro, Diana C.F., Patel, Vijay, Bartlett, Christopher P., Nozaki, Shingo, Grant, Thomas D., Gowdy, James A., Thompson, Gary S., Kalverda, Arnout P., Snell, Edward H., Niki, Hironori, Pearson, Arwen R., Webb, Michael E.

“…Coenzyme A (CoA) is an ubiquitous and essential cofactor, synthesized from the precursor pantothenate. Vitamin biosynthetic pathways are normally tightly…”
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Using photocaging for fast time‐resolved structural biology studies by Monteiro, Diana C. F., Amoah, Emmanuel, Rogers, Cromarte, Pearson, Arwen R.

“…Careful selection of photocaging approaches is critical to achieve fast and well synchronized reaction initiation and perform successful time‐resolved…”
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X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease by Günther, Sebastian, Reinke, Patrick Y A, Fernández-García, Yaiza, Lieske, Julia, Lane, Thomas J, Ginn, Helen M, Koua, Faisal H M, Ehrt, Christiane, Ewert, Wiebke, Oberthuer, Dominik, Yefanov, Oleksandr, Meier, Susanne, Lorenzen, Kristina, Krichel, Boris, Kopicki, Janine-Denise, Gelisio, Luca, Brehm, Wolfgang, Dunkel, Ilona, Seychell, Brandon, Gieseler, Henry, Norton-Baker, Brenna, Escudero-Pérez, Beatriz, Domaracky, Martin, Saouane, Sofiane, Tolstikova, Alexandra, White, Thomas A, Hänle, Anna, Groessler, Michael, Fleckenstein, Holger, Trost, Fabian, Galchenkova, Marina, Gevorkov, Yaroslav, Li, Chufeng, Awel, Salah, Peck, Ariana, Barthelmess, Miriam, Schlünzen, Frank, Lourdu Xavier, P, Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Falke, Sven, Srinivasan, Vasundara, França, Bruno Alves, Schwinzer, Martin, Brognaro, Hévila, Rogers, Cromarte, Melo, Diogo, Zaitseva-Doyle, Joanna J, Knoska, Juraj, Peña-Murillo, Gisel E, Mashhour, Aida Rahmani, Hennicke, Vincent, Fischer, Pontus, Hakanpää, Johanna, Meyer, Jan, Gribbon, Philip, Ellinger, Bernhard, Kuzikov, Maria, Wolf, Markus, Beccari, Andrea R, Bourenkov, Gleb, von Stetten, David, Pompidor, Guillaume, Bento, Isabel, Panneerselvam, Saravanan, Karpics, Ivars, Schneider, Thomas R, Garcia-Alai, Maria Marta, Niebling, Stephan, Günther, Christian, Schmidt, Christina, Schubert, Robin, Han, Huijong, Boger, Juliane, Monteiro, Diana C F, Zhang, Linlin, Sun, Xinyuanyuan, Pletzer-Zelgert, Jonathan, Wollenhaupt, Jan, Feiler, Christian G, Weiss, Manfred S, Schulz, Eike-Christian, Mehrabi, Pedram, Karničar, Katarina, Usenik, Aleksandra, Loboda, Jure, Tidow, Henning, Chari, Ashwin, Hilgenfeld, Rolf, Uetrecht, Charlotte, Cox, Russell, Zaliani, Andrea, Beck, Tobias, Rarey, Matthias, Günther, Stephan, Turk, Dusan, Hinrichs, Winfried, Chapman, Henry N, Pearson, Arwen R

“…The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the…”
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Megahertz serial crystallography by Wiedorn, Max O., Bean, Richard, Werner, Nadine, Abbey, Brian, Adriano, Luigi, Aplin, Steve, Awel, Salah, Ayyer, Kartik, Bajt, Saša, Barák, Imrich, Bielecki, Johan, Botha, Sabine, Boukhelef, Djelloul, Brehm, Wolfgang, Brockhauser, Sandor, Cheviakov, Igor, Cruz-Mazo, Francisco, Darmanin, Connie, Domaracky, Martin, Dörner, Katerina, Du, Yang, Fangohr, Hans, Fleckenstein, Holger, Frank, Matthias, Fromme, Petra, Gañán-Calvo, Alfonso M., Gevorkov, Yaroslav, Giewekemeyer, Klaus, Ginn, Helen Mary, Graafsma, Heinz, Graceffa, Rita, Greiffenberg, Dominic, Gumprecht, Lars, Hauf, Steffen, Heymann, Michael, Horke, Daniel A., Hunter, Mark S., Imlau, Siegfried, Kaukher, Alexander, Kim, Yoonhee, Klyuev, Alexander, Knoška, Juraj, Kobe, Bostjan, Kuhn, Manuela, Kupitz, Christopher, Küpper, Jochen, Laurus, Torsten, Le Cong, Karoline, Letrun, Romain, Xavier, P. Lourdu, Maia, Luis, Maia, Filipe R. N. C., Messerschmidt, Marc, Metz, Markus, Michelat, Thomas, Mills, Grant, Mühlig, Kerstin, Münnich, Astrid, Nette, Julia, Nuguid, Theresa, Orville, Allen M., Pandey, Suraj, Pena, Gisel, Villanueva-Perez, Pablo, Poehlsen, Jennifer, Previtali, Gianpietro, Redecke, Lars, Riekehr, Winnie Maria, Rohde, Holger, Safenreiter, Tatiana, Sarrou, Iosifina, Sato, Tokushi, Schmidt, Marius, Schmitt, Bernd, Schönherr, Robert, Schulz, Joachim, Sellberg, Jonas A., Shelby, Megan L., Sikorski, Marcin, Stan, Claudiu A., Shi, Xintian, Stern, Stephan, Sztuk-Dambietz, Jola, Szuba, Janusz, Tolstikova, Aleksandra, Trebbin, Martin, Trunk, Ulrich, Vagovic, Patrik, Ve, Thomas, Weinhausen, Britta, White, Thomas A., Wrona, Krzysztof, Yefanov, Oleksandr, Zatsepin, Nadia, Zhang, Jiaguo, Perbandt, Markus, Mancuso, Adrian P., Betzel, Christian, Chapman, Henry, Barty, Anton

“…The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more…”
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Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales by Klebl, David P., Gravett, Molly S.C., Kontziampasis, Dimitrios, Wright, David J., Bon, Robin S., Monteiro, Diana C.F., Trebbin, Martin, Sobott, Frank, White, Howard D., Darrow, Michele C., Thompson, Rebecca F., Muench, Stephen P.

“…A host of new technologies are under development to improve the quality and reproducibility of cryoelectron microscopy (cryoEM) grid preparation. Here we have…”
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Solution blow spinning of polymer/nanocomposite micro-/nanofibers with tunable diameters and morphologies using a gas dynamic virtual nozzle by Vasireddi, Ramakrishna, Kruse, Joscha, Vakili, Mohammad, Kulkarni, Satishkumar, Keller, Thomas F., Monteiro, Diana C. F., Trebbin, Martin

“…Uniform endless fibers are ubiquitous and their applications range from functional textiles over biomedical engineering to high-performance filtering and drug…”
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Sample deposition onto cryo‐EM grids: from sprays to jets and back by Klebl, David P., Monteiro, Diana C. F., Kontziampasis, Dimitrios, Kopf, Florian, Sobott, Frank, White, Howard D., Trebbin, Martin, Muench, Stephen P.

“…Despite the great strides made in the field of single‐particle cryogenic electron microscopy (cryo‐EM) in microscope design, direct electron detectors and new…”
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Homogeneous batch micro‐crystallization of proteins from ammonium sulfate by Stohrer, Claudia, Horrell, Sam, Meier, Susanne, Sans, Marta, von Stetten, David, Hough, Michael, Goldman, Adrian, Monteiro, Diana C. F., Pearson, Arwen R.

“…The emergence of X‐ray free‐electron lasers has led to the development of serial macromolecular crystallography techniques, making it possible to study smaller…”
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Plug-and-play polymer microfluidic chips for hydrated, room temperature, fixed-target serial crystallography by Gilbile, Deepshika, Shelby, Megan L, Lyubimov, Artem Y, Wierman, Jennifer L, Monteiro, Diana C F, Cohen, Aina E, Russi, Silvia, Coleman, Matthew A, Frank, Matthias, Kuhl, Tonya L

“…The practice of serial X-ray crystallography (SX) depends on efficient, continuous delivery of hydrated protein crystals while minimizing background…”
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A microfluidic flow‐focusing device for low sample consumption serial synchrotron crystallography experiments in liquid flow by Monteiro, Diana C. F., Vakili, Mohammad, Harich, Jessica, Sztucki, Michael, Meier, Susanne M., Horrell, Sam, Josts, Inokentijs, Trebbin, Martin

“…Serial synchrotron crystallography allows low X‐ray dose, room‐temperature crystal structures of proteins to be determined from a population of microcrystals…”
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Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands by Monteiro, Diana C F, Phillips, Roger M, Crossley, Benjamin D, Fielden, Jake, Willans, Charlotte E

“…A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to…”
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Megahertz pulse trains enable multi-hit serial femtosecond crystallography experiments at X-ray free electron lasers by Holmes, Susannah, Kirkwood, Henry J., Bean, Richard, Giewekemeyer, Klaus, Martin, Andrew V., Hadian-Jazi, Marjan, Wiedorn, Max O., Oberthür, Dominik, Marman, Hugh, Adriano, Luigi, Al-Qudami, Nasser, Bajt, Saša, Barák, Imrich, Bari, Sadia, Bielecki, Johan, Brockhauser, Sandor, Coleman, Mathew A., Cruz-Mazo, Francisco, Danilevski, Cyril, Dörner, Katerina, Gañán-Calvo, Alfonso M., Graceffa, Rita, Fanghor, Hans, Heymann, Michael, Frank, Matthias, Kaukher, Alexander, Kim, Yoonhee, Kobe, Bostjan, Knoška, Juraj, Laurus, Torsten, Letrun, Romain, Maia, Luis, Messerschmidt, Marc, Metz, Markus, Michelat, Thomas, Mills, Grant, Molodtsov, Serguei, Monteiro, Diana C. F., Morgan, Andrew J., Münnich, Astrid, Peña Murillo, Gisel E., Previtali, Gianpietro, Round, Adam, Sato, Tokushi, Schubert, Robin, Schulz, Joachim, Shelby, Megan, Seuring, Carolin, Sellberg, Jonas A., Sikorski, Marcin, Silenzi, Alessandro, Stern, Stephan, Sztuk-Dambietz, Jola, Szuba, Janusz, Trebbin, Martin, Vagovic, Patrick, Ve, Thomas, Weinhausen, Britta, Wrona, Krzysztof, Xavier, Paul Lourdu, Xu, Chen, Yefanov, Oleksandr, Nugent, Keith A., Chapman, Henry N., Mancuso, Adrian P., Barty, Anton, Abbey, Brian, Darmanin, Connie

“…The European X-ray Free Electron Laser (XFEL) and Linac Coherent Light Source (LCLS) II are extremely intense sources of X-rays capable of generating Serial…”
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3D-MiXD: 3D-printed X-ray-compatible microfluidic devices for rapid, low-consumption serial synchrotron crystallography data collection in flow by Monteiro, Diana C F, von Stetten, David, Stohrer, Claudia, Sans, Marta, Pearson, Arwen R, Santoni, Gianluca, van der Linden, Peter, Trebbin, Martin

“…Serial crystallography has enabled the study of complex biological questions through the determination of biomolecular structures at room temperature using low…”
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Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules by Levantino, Matteo, Yorke, Briony A, Monteiro, Diana CF, Cammarata, Marco, Pearson, Arwen R

“…•Time-resolved structural information is key to understanding biological mechanism.•The molecular details of biomolecular catalysis and regulation can be…”
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The Mechanism of Regulation of Pantothenate Biosynthesis by the PanD–PanZ·AcCoA Complex Reveals an Additional Mode of Action for the Antimetabolite N‑Pentyl Pantothenamide (N5-Pan) by Arnott, Zoe L. P, Nozaki, Shingo, Monteiro, Diana C. F, Morgan, Holly E, Pearson, Arwen R, Niki, Hironori, Webb, Michael E

“…The antimetabolite pentyl pantothenamide has broad spectrum antibiotic activity but exhibits enhanced activity against Escherichia coli. The PanDZ complex has…”
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Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature by Moreno-Chicano, Tadeo, Carey, Leiah M, Axford, Danny, Beale, John H, Doak, R Bruce, Duyvesteyn, Helen M E, Ebrahim, Ali, Henning, Robert W, Monteiro, Diana C F, Myles, Dean A, Owada, Shigeki, Sherrell, Darren A, Straw, Megan L, Šrajer, Vukica, Sugimoto, Hiroshi, Tono, Kensuke, Tosha, Takehiko, Tews, Ivo, Trebbin, Martin, Strange, Richard W, Weiss, Kevin L, Worrall, Jonathan A R, Meilleur, Flora, Owen, Robin L, Ghiladi, Reza A, Hough, Michael A

“…Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in…”
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Evaluation of serial crystallographic structure determination within megahertz pulse trains by Yefanov, Oleksandr, Oberthür, Dominik, Bean, Richard, Wiedorn, Max O., Knoska, Juraj, Pena, Gisel, Awel, Salah, Gumprecht, Lars, Domaracky, Martin, Sarrou, Iosifina, Lourdu Xavier, P., Metz, Markus, Bajt, Saša, Mariani, Valerio, Gevorkov, Yaroslav, White, Thomas A., Tolstikova, Aleksandra, Villanueva-Perez, Pablo, Seuring, Carolin, Aplin, Steve, Estillore, Armando D., Küpper, Jochen, Klyuev, Alexander, Kuhn, Manuela, Laurus, Torsten, Graafsma, Heinz, Monteiro, Diana C. F., Trebbin, Martin, Maia, Filipe R. N. C., Cruz-Mazo, Francisco, Gañán-Calvo, Alfonso M., Heymann, Michael, Darmanin, Connie, Abbey, Brian, Schmidt, Marius, Fromme, Petra, Giewekemeyer, Klaus, Sikorski, Marcin, Graceffa, Rita, Vagovic, Patrik, Kluyver, Thomas, Bergemann, Martin, Fangohr, Hans, Sztuk-Dambietz, Jolanta, Hauf, Steffen, Raab, Natascha, Bondar, Valerii, Mancuso, Adrian P., Chapman, Henry, Barty, Anton

“…The new European X-ray Free-Electron Laser (European XFEL) is the first X-ray free-electron laser capable of delivering intense X-ray pulses with a megahertz…”
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Formation of a heterooctameric complex between aspartate α-decarboxylase and its cognate activating factor, PanZ, is CoA-dependent by Monteiro, Diana C.F., Rugen, Michael D., Shepherd, Dale, Nozaki, Shingo, Niki, Hironori, Webb, Michael E.

“…► PanZ is required for formation of the pyruvoyl-cofactor in PanD (ADC) in vivo. ► PanZ and PanD interact with nanomolar affinity. ► Interaction of PanZ and…”
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