Search Results - "Monte, Maria J"

Bile Acids in Physiology, Pathology and Pharmacology by Marin, Jose J G, Macias, Rocio I R, Briz, Oscar, Banales, Jesus M, Monte, Maria J

“…Bile acids, synthesized by hepatocytes from cholesterol, are specific and quantitatively important organic components of bile, where they are the main driving…”
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Bile acids： Chemistry, physiology, and pathophysiology by Monte, Maria J, Marin, Jose J G, Antelo, Alvaro, Vazquez-Tato, Jose

“…The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physicalchemical and biological characteristics. They are…”
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TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation by Labiano, Ibone, Agirre-Lizaso, Aloña, Olaizola, Paula, Echebarria, Anne, Huici-Izagirre, Maider, Olaizola, Irene, Esparza-Baquer, Aitor, Sharif, Omar, Hijona, Elizabeth, Milkiewicz, Piotr, Milkiewicz, Malgorzata, González-Romero, Francisco, Aspichueta, Patricia, Monte, Maria J., Marin, Jose J.G., Vucur, Mihael, Luedde, Tom, Marzioni, Marco, Mann, Derek A., Bujanda, Luis, Rodrigues, Pedro M., Banales, Jesus M., Perugorria, Maria J.

“…Inflammation, particularly that mediated by bacterial components translocating from the gut to the liver and binding to toll-like receptors (TLRs), is central…”
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JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma by Manieri, Elisa, Folgueira, Cintia, Rodríguez, María Elena, Leiva-Vega, Luis, Esteban-Lafuente, Laura, Chen, Chaobo, Cubero, Francisco Javier, Barrett, Tamera, Cavanagh-Kyros, Julie, Seruggia, Davide, Rosell, Alejandro, Sanchez-Cabo, Fátima, Gómez, Manuel Jose, Monte, Maria J., Marin, Jose J. G., Davis, Roger J., Mora, Alfonso, Sabio, Guadalupe

“…Metabolic stress causes activation of the cJun NH₂-terminal kinase (JNK) signal transduction pathway. It is established that one consequence of JNK activation…”
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Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition by Vaquero, Javier, Monte, Maria J., Dominguez, Mercedes, Muntané, Jordi, Marin, Jose J.G.

“…The farnesoid X receptor (FXR) is a key sensor in bile acid homeostasis. Although four human FXR isoforms have been identified, the physiological role of this…”
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Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy by Lozano, Elisa, Macias, Rocio I.R., Monte, Maria J., Asensio, Maitane, Carmen, Sofia, Sanchez‐Vicente, Laura, Alonso‐Peña, Marta, Al‐Abdulla, Ruba, Munoz‐Garrido, Patricia, Satriano, Letizia, O'Rourke, Colm J., Banales, Jesus M., Avila, Matias A., Martinez‐Chantar, Maria L., Andersen, Jesper B., Briz, Oscar, Marin, Jose J.G.

“…Although the multi‐tyrosine kinase inhibitor sorafenib is useful in the treatment of several cancers, cholangiocarcinoma (CCA) is refractory to this drug…”
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Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice by Uriarte, Iker, Fernandez-Barrena, Maite G, Monte, Maria J, Latasa, Maria U, Chang, Haisul C Y, Carotti, Simone, Vespasiani-Gentilucci, Umberto, Morini, Sergio, Vicente, Eva, Concepcion, Axel R, Medina, Juan F, Marin, José Juan G, Berasain, Carmen, Prieto, Jesus, Avila, Matías A

“…Cholestasis is associated with increased liver injury and morbidity after partial hepatectomy (PH), yet bile acids (BAs) are emerging as important mediators of…”
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Role of Genetic Variations in the Hepatic Handling of Drugs by Marin, Jose J G, Serrano, Maria A, Monte, Maria J, Sanchez-Martin, Anabel, Temprano, Alvaro G, Briz, Oscar, Romero, Marta R

“…The liver plays a pivotal role in drug handling due to its contribution to the processes of detoxification (phases 0 to 3). In addition, the liver is also an…”
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Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development by Lozano, Elisa, Sanchez-Vicente, Laura, Monte, Maria J, Herraez, Elisa, Briz, Oscar, Banales, Jesus M, Marin, Jose J G, Macias, Rocio I R

“…Bile acid accumulation in liver with cholangiolar neoplastic lesions may occur before cholestasis is clinically detected. Whether this favors intrahepatic…”
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Impact of aging on primary liver cancer: epidemiology, pathogenesis and therapeutics by Macias, Rocio I R, Monte, Maria J, Serrano, Maria A, González-Santiago, Jesús M, Martín-Arribas, Isabel, Simão, André L, Castro, Rui E, González-Gallego, Javier, Mauriz, José L, Marin, Jose J G

“…Aging involves progressive physiological and metabolic reprogramming to adapt to gradual deterioration of organs and functions. This includes mechanisms of…”
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Enhanced antitumour drug delivery to cholangiocarcinoma through the apical sodium-dependent bile acid transporter (ASBT) by Lozano, Elisa, Monte, Maria J., Briz, Oscar, Hernández-Hernández, Angel, Banales, Jesus M., Marin, Jose J.G., Macias, Rocio I.R.

“…Novel antitumour drugs, such as cationic tyrosine kinase inhibitors, are useful in many types of cancer but not in others, such as cholangiocarcinoma (CCA),…”
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Lactation during cholestasis: Role of ABC proteins in bile acid traffic across the mammary gland by Blazquez, Alba M. G., Macias, Rocio I. R., Cives-Losada, Candela, de la Iglesia, Alberto, Marin, Jose J. G., Monte, Maria J.

“…Transporters involved in bile acid (BA) handling by the mammary gland are poorly understood. Here we have investigated the role of ABC proteins in blood-milk…”
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The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy by Marin, Jose JG, Monte, Maria J, Blazquez, Alba G, Macias, Rocio IR, Serrano, Maria A, Briz, Oscar

“…A major difficulty in the treatment of cancers is the poor response of many tumors to pharmacological regimens. This situation can be accounted for by the…”
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Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis by Lumbreras, Sara, Ricobaraza, Ana, Baila-Rueda, Lucia, Gonzalez-Aparicio, Manuela, Mora-Jimenez, Lucia, Uriarte, Iker, Bunuales, Maria, Avila, Matias A., Monte, Maria J., Marin, Jose J.G., Cenarro, Ana, Gonzalez-Aseguinolaza, Gloria, Hernandez-Alcoceba, Ruben

“…Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption…”
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Impact of Liver Inflammation on Bile Acid Side Chain Shortening and Amidation by Alonso-Peña, Marta, Espinosa-Escudero, Ricardo, Hermanns, Heike M, Briz, Oscar, Herranz, Jose M, Garcia-Ruiz, Carmen, Fernandez-Checa, Jose C, Juamperez, Javier, Avila, Matias, Argemi, Josepmaria, Bataller, Ramon, Crespo, Javier, Monte, Maria J, Geier, Andreas, Herraez, Elisa, Marin, Jose J G

“…Bile acid (BA) synthesis from cholesterol by hepatocytes is inhibited by inflammatory cytokines. Whether liver inflammation also affects BA side chain…”
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Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy by Vallejo, Marta, Briz, Oscar, Serrano, Maria A., Monte, Maria J., Marin, Jose J.G.

“…Progesterone metabolites such as 5α-pregnan-3α-ol-20-one (PM4) are elevated in serum of women with intrahepatic cholestasis of pregnancy (ICP). When assayed in…”
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Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice by Fernández-Barrena, Maite G, Monte, Maria J, Latasa, Maria U, Uriarte, Iker, Vicente, Eva, Chang, Haisul C.Y, Rodriguez-Ortigosa, Carlos M, Elferink, Ronald Oude, Berasain, Carmen, Marin, Jose J.G, Prieto, Jesus, Ávila, Matias A

“…Background & Aims Bile acids (BA) are increasingly recognized as important modulators of liver regeneration. Increased enterohepatic BA flux has been proposed…”
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Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps by Ballestero, Maria R., Monte, Maria J., Briz, Oscar, Jimenez, Felipe, Martin, Francisco Gonzalez-San, Marin, Jose J.G.

“…Drug targeting might help to overcome resistance to chemotherapy. Here we investigated whether colon cancer and polyps do express functional carriers involved…”
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Pathophysiological and pharmacological implications of elucidating the molecular bases of the interaction between HBV and the bile acid transporter NTCP by Romero, Marta R, Monte, Maria J, Marin, Jose J.G., Ph.D

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Liver metabolic/oxidative stress induces hepatic and extrahepatic changes in the expression of the vitamin C transporters SVCT1 and SVCT2 by Hierro, Carlos, Monte, Maria J, Lozano, Elisa, Gonzalez-Sanchez, Ester, Marin, Jose J. G, Macias, Rocio I. R

“…PURPOSE: Owing to its ability to inactivate harmful radicals, vitamin C plays a key role in antioxidant defense. The bioavailability of this vitamin depends…”
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