Search Results - "Montana, V G"

Structural Determinants of Ligand Binding Selectivity between the Peroxisome Proliferator-Activated Receptors by Xu, H. Eric, Lambert, Millard H., Montana, Valerie G., Plunket, Kelli D., Moore, Linda B., Collins, Jon L., Oplinger, Jeffery A., Kliewer, Steven A., Gampe, Robert T., McKee, David D., Moore, John T., Willson, Timothy M.

“…The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of glucose, lipid, and cholesterol metabolism. We report the x-ray…”
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Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix by Gampe, Jr, R T, Montana, V G, Lambert, M H, Wisely, G B, Milburn, M V, Xu, H E

“…The 9-cis-retinoic acid receptors (RXRalpha, RXRbeta, and RXRgamma) are nuclear receptors that play key roles in multiple hormone-signaling pathways…”
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Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition by Bledsoe, Randy K., Montana, Valerie G., Stanley, Thomas B., Delves, Chris J., Apolito, Christopher J., McKee, David D., Consler, Thomas G., Parks, Derek J., Stewart, Eugene L., Willson, Timothy M., Lambert, Millard H., Moore, John T., Pearce, Kenneth H., Xu, H.Eric

“…Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we…”
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Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPAR α by Xu, H. Eric, Stanley, Thomas B, Montana, Valerie G, Lambert, Millard H, Shearer, Barry G, Cobb, Jeffery E, McKee, David D, Galardi, Cristin M, Plunket, Kelli D, Nolte, Robert T, Parks, Derek J, Moore, John T, Kliewer, Steven A, Willson, Timothy M, Stimmel, Julie B

“…Repression of gene transcription by nuclear receptors is mediated by interactions with co-repressor proteins such as SMRT and N-CoR, which in turn recruit…”
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Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors by Gampe, Robert T., Montana, Valerie G., Lambert, Millard H., Miller, Aaron B., Bledsoe, Randy K., Milburn, Michael V., Kliewer, Steven A., Willson, Timothy M., Xu, H.Eric

“…The nuclear receptor PPAR gamma /RXR alpha heterodimer regulates glucose and lipid homeostasis and is the target for the antidiabetic drugs GI262570 and the…”
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Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors by Xu, H.Eric, Lambert, Millard H, Montana, Valerie G, Parks, Derek J, Blanchard, Steven G, Brown, Peter J, Sternbach, Daniel D, Lehmann, Jürgen M, Wisely, G.Bruce, Willson, Timothy M, Kliewer, Steven A, Milburn, Michael V

“…The peroxisome proliferator–activated receptors (PPARs) are nuclear receptors for fatty acids (FAs) that regulate glucose and lipid homeostasis. We report the…”
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Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A by Fauman, Eric B., Cogswell, John P., Lovejoy, Brett, Rocque, Warren J., Holmes, William, Montana, Valerie G., Piwnica-Worms, Helen, Rink, Martin J., Saper, Mark A.

“…Cdc25 phosphatases activate the cell division kinases throughout the cell cycle. The 2.3 Å structure of the human Cdc25A catalytic domain reveals a small α/β…”
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Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity by Sznaidman, Marcos L., Haffner, Curt D., Maloney, Patrick R., Fivush, Adam, Chao, Esther, Goreham, Donna, Sierra, Michael L., LeGrumelec, Christelle, Xu, H.Eric, Montana, Valerie G., Lambert, Millard H., Willson, Timothy M., Oliver, William R., Sternbach, Daniel D.

“…We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ)…”
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Structure-Based Design of Potent Retinoid X Receptor α Agonists by Haffner, Curt D., Lenhard, James M., Miller, Aaron B., McDougald, Darryl L., Dwornik, Kate, Ittoop, Olivia R., Gampe, Robert T., Xu, H. Eric, Blanchard, Steve, Montana, Valerie G., Consler, Tom G., Bledsoe, Randy K., Ayscue, Andrea, Croom, Dallas

“…A series of tetrahydrobenzofuranyl and tetrahydrobenzothienyl propenoic acids that showed potent agonist activity against RXRα were synthesized via a…”
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Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors by Gampe, Jr, R T, Montana, V G, Lambert, M H, Miller, A B, Bledsoe, R K, Milburn, M V, Kliewer, S A, Willson, T M, Xu, H E

“…The nuclear receptor PPARgamma/RXRalpha heterodimer regulates glucose and lipid homeostasis and is the target for the antidiabetic drugs GI262570 and the…”
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Subtype Specific Effects of Peroxisome Proliferator-Activated Receptor Ligands on Corepressor Affinity by Stanley, Thomas B, Leesnitzer, Lisa M, Montana, Valerie G, Galardi, Cristin M, Lambert, Millard H, Holt, Jason A, Xu, H. Eric, Moore, Linda B, Blanchard, Steven G, Stimmel, Julie B

“…Natural ligands for nuclear receptors are believed to activate gene transcription by causing dissociation of corepressors and promoting the association of…”
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Alteration of a Single Amino Acid in Peroxisome Proliferator-Activated Receptor-α (PPARα) Generates a PPARδ Phenotype by Takada, Ichiro, Yu, Ruth T, Xu, H. Eric, Lambert, Millard H, Montana, Valerie G, Kliewer, Steven A, Evans, Ronald M, Umesono, Kazuhiko

“…Three pharmacologically important nuclear receptors, the peroxisome proliferator-activated receptors (PPARs α,γ , and δ), mediate key transcriptional responses…”
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