Search Results - "Montañes, José Ordovas"

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip by Bein, Amir, Kim, Seongmin, Goyal, Girija, Cao, Wuji, Fadel, Cicely, Naziripour, Arash, Sharma, Sanjay, Swenor, Ben, LoGrande, Nina, Nurani, Atiq, Miao, Vincent N, Navia, Andrew W, Ziegler, Carly G K, Montañes, José Ordovas, Prabhala, Pranav, Kim, Min Sun, Prantil-Baun, Rachelle, Rodas, Melissa, Jiang, Amanda, O'Sullivan, Lucy, Tillya, Gladness, Shalek, Alex K, Ingber, Donald E

“…Many patients infected with coronaviruses, such as SARS-CoV-2 and NL63 that use ACE2 receptors to infect cells, exhibit gastrointestinal symptoms and viral…”
Get full text

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation by Kummerlowe, Conner, Mwakamui, Simutanyi, Hughes, Travis K, Mulugeta, Nolawit, Mudenda, Victor, Besa, Ellen, Zyambo, Kanekwa, Shay, Jessica E S, Fleming, Ira, Vukovic, Marko, Doran, Ben A, Aicher, Toby P, Wadsworth, 2nd, Marc H, Bramante, Juliet Tongue, Uchida, Amiko M, Fardoos, Rabiah, Asowata, Osaretin E, Herbert, Nicholas, Yilmaz, Ömer H, Kløverpris, Henrik N, Garber, John J, Ordovas-Montañes, José, Gartner, Zev J, Wallach, Thomas, Shalek, Alex K, Kelly, Paul

“…Environmental enteropathy (EE) is a subclinical condition of the small intestine that is highly prevalent in low- and middle-income countries. It is thought to…”
Get more information

Distribution and storage of inflammatory memory in barrier tissues by Ordovas-Montanes, Jose, Beyaz, Semir, Rakoff-Nahoum, Seth, Shalek, Alex K.

“…Memories of previous immune events enable barrier tissues to rapidly recall distinct environmental exposures. To effectively inform future responses, these…”
Get full text

Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis by Zhang, Xinbo, McDonald, Jeffrey G., Aryal, Binod, Canfrán-Duque, Alberto, Goldberg, Emily L., Araldi, Elisa, Ding, Wen, Fan, Yuhua, Thompson, Bonne M., Singh, Abhishek K., Li, Qian, Tellides, George, Ordovás-Montanes, Jose, Milian, Rolando García, Dixit, Vishwa Deep, Ikonen, Elina, Suárez, Yajaira, Fernández-Hernando, Carlos

“…Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent immune regulators of macrophages in response to inflammatory stimuli…”
Get full text

Robust differentiation of human enteroendocrine cells from intestinal stem cells by Zeve, Daniel, Stas, Eric, de Sousa Casal, Joshua, Mannam, Prabhath, Qi, Wanshu, Yin, Xiaolei, Dubois, Sarah, Shah, Manasvi S., Syverson, Erin P., Hafner, Sophie, Karp, Jeffrey M., Carlone, Diana L., Ordovas-Montanes, Jose, Breault, David T.

“…Enteroendocrine (EE) cells are the most abundant hormone-producing cells in humans and are critical regulators of energy homeostasis and gastrointestinal…”
Get full text

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis by Smillie, Christopher S., Biton, Moshe, Ordovas-Montanes, Jose, Sullivan, Keri M., Burgin, Grace, Graham, Daniel B., Herbst, Rebecca H., Rogel, Noga, Slyper, Michal, Waldman, Julia, Sud, Malika, Andrews, Elizabeth, Velonias, Gabriella, Haber, Adam L., Jagadeesh, Karthik, Vickovic, Sanja, Yao, Junmei, Stevens, Christine, Dionne, Danielle, Nguyen, Lan T., Villani, Alexandra-Chloé, Hofree, Matan, Creasey, Elizabeth A., Huang, Hailiang, Rozenblatt-Rosen, Orit, Garber, John J., Khalili, Hamed, Desch, A. Nicole, Daly, Mark J., Ananthakrishnan, Ashwin N., Shalek, Alex K., Xavier, Ramnik J., Regev, Aviv

“…Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC). To understand their cell type specificities and pathways of…”
Get full text

Induced pluripotent stem cells: A novel frontier in the study of human primary immunodeficiencies by Pessach, Itai M., MD, PhD, Ordovas-Montanes, Jose, BA, Zhang, Shen-Ying, MD, Casanova, Jean-Laurent, MD, PhD, Giliani, Silvia, PhD, Gennery, Andrew R., MD, Al-Herz, Waleed, MD, Manos, Philip D., PhD, Schlaeger, Thorsten M., PhD, Park, In-Hyun, PhD, Rucci, Francesca, PhD, Agarwal, Suneet, MD, PhD, Mostoslavsky, Gustavo, MD, PhD, Daley, George Q., MD, Notarangelo, Luigi D., MD

“…Background The novel ability to epigenetically reprogram somatic cells into induced pluripotent stem cells (iPSCs) through the exogenous expression of…”
Get full text

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19 by Bernardes, Joana P., Tran, Florian, Best, Lena, Bordoni, Dora, Josephs-Spaulding, Jonathan, Köhler, Philipp, Künstner, Axel, Rosati, Elisa, Bacher, Petra, Bruse, Niklas, Franzenburg, Sören, Frey, Norbert, Fuß, Janina, Glück, Andreas, Hamm, Jacob, Imm, Simon, Kaiser, Sina, Lange, Christoph, Laue, Georg, Marinos, Georgios, Pickkers, Peter, Rabe, Klaus F., Renz, Alina, Röcken, Christoph, Rupp, Jan, Schaffarzyk, Annika, Scheffold, Alexander, Schulte-Schrepping, Jonas, Skowasch, Dirk, Ulas, Thomas, Wandinger, Klaus-Peter, Wittig, Michael, Zimmermann, Johannes, Busch, Hauke, Hoyer, Bimba F., Kaleta, Christoph, Heyckendorf, Jan, Rybniker, Jan, Schultze, Joachim L., Rosenstiel, Philip, Banovich, Nicholas E., Desai, Tushar, Eickelberg, Oliver, Haniffa, Muzlifa, Horvath, Peter, Kropski, Jonathan A., Lafyatis, Robert, Meyer, Kerstin, Nawijn, Martijn C., Nikolic, Marko, Ordovas Montanes, Jose, Pe’er, Dana, Tata, Purushothama Rao, Rawlins, Emma, Regev, Aviv, Reyfman, Paul, Samakovlis, Christos, Schultze, Joachim, Shalek, Alex, Shepherd, Douglas, Spence, Jason, Theis, Fabian, van den Berge, Maarten, von Papen, Michael, Whitsett, Jeffrey, Angelov, Angel, Bals, Robert, Bonifacio, Ezio, Colme-Tatche, Maria, Diefenbach, Andreas, Dilthey, Alexander, Fischer, Nicole, Gagneur, Julien, Goesmann, Alexander, Kallies, René, Kehr, Birte, Keller, Andreas, Kim-Hellmuth, Sarah, Korbel, Jan O., Kurth, Ingo, Landthaler, Markus, Li, Yang, Ludwig, Kerstin, Makarewicz, Oliwia, Nöthen, Markus, Nürnberg, Peter, Ohler, Uwe, Overmann, Jörg, Peter, Silke, Pfeffer, Klaus, Poetsch, Anna R., Rajewsky, Niklaus, Ralser, Markus, Saliba, Antoine-Emmanuel, Schulte, Eva-Christina, Sczyrba, Alexander, Stegle, Oliver, Stoye, Jens, von Kleist, Max, Walker, Andreas

“…Temporal resolution of cellular features associated with a severe COVID-19 disease trajectory is needed for understanding skewed immune responses and defining…”
Get full text

Allergic inflammatory memory in human respiratory epithelial progenitor cells by Ordovas-Montanes, Jose, Dwyer, Daniel F., Nyquist, Sarah K., Buchheit, Kathleen M., Vukovic, Marko, Deb, Chaarushena, Wadsworth, Marc H., Hughes, Travis K., Kazer, Samuel W., Yoshimoto, Eri, Cahill, Katherine N., Bhattacharyya, Neil, Katz, Howard R., Berger, Bonnie, Laidlaw, Tanya M., Boyce, Joshua A., Barrett, Nora A., Shalek, Alex K.

“…Barrier tissue dysfunction is a fundamental feature of chronic human inflammatory diseases 1 . Specialized subsets of epithelial cells—including secretory and…”
Get full text

Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration by Pepe-Mooney, Brian J., Dill, Michael T., Alemany, Anna, Ordovas-Montanes, Jose, Matsushita, Yuki, Rao, Anuradha, Sen, Anushna, Miyazaki, Makoto, Anakk, Sayeepriyadarshini, Dawson, Paul A., Ono, Noriaki, Shalek, Alex K., van Oudenaarden, Alexander, Camargo, Fernando D.

“…The liver can substantially regenerate after injury, with both main epithelial cell types, hepatocytes and biliary epithelial cells (BECs), playing important…”
Get full text

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19 by Ziegler, Carly G.K., Miao, Vincent N., Owings, Anna H., Navia, Andrew W., Tang, Ying, Bromley, Joshua D., Lotfy, Peter, Sloan, Meredith, Laird, Hannah, Williams, Haley B., George, Micayla, Drake, Riley S., Christian, Taylor, Parker, Adam, Sindel, Campbell B., Burger, Molly W., Pride, Yilianys, Hasan, Mohammad, Abraham, George E., Senitko, Michal, Robinson, Tanya O., Shalek, Alex K., Glover, Sarah C., Horwitz, Bruce H., Ordovas-Montanes, Jose

“…SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals present with isolated upper respiratory symptoms, suggesting potential to…”
Get full text

The Regulation of Immunological Processes by Peripheral Neurons in Homeostasis and Disease by Ordovas-Montanes, Jose, Rakoff-Nahoum, Seth, Huang, Siyi, Riol-Blanco, Lorena, Barreiro, Olga, von Andrian, Ulrich H

“…The nervous system and the immune system are the principal sensory interfaces between the internal and external environment. They are responsible for…”
Get full text

Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies by Hughes, Travis K., Wadsworth, Marc H., Gierahn, Todd M., Do, Tran, Weiss, David, Andrade, Priscila R., Ma, Feiyang, de Andrade Silva, Bruno J., Shao, Shuai, Tsoi, Lam C., Ordovas-Montanes, Jose, Gudjonsson, Johann E., Modlin, Robert L., Love, J. Christopher, Shalek, Alex K.

“…High-throughput single-cell RNA-sequencing (scRNA-seq) methodologies enable characterization of complex biological samples by increasing the number of cells…”
Get full text

Cellular and inter-cellular rewiring of the human colon during ulcerative colitis by Smillie, Christopher S., Biton, Moshe, Ordovas-Montañes, José, Sullivan, Keri M., Burgin, Grace, Graham, Daniel B., Herbst, Rebecca H., Rogel, Noga, Slyper, Michal, Waldman, Julia, Sud, Malika, Andrews, Elizabeth, Velonias, Gabriella, Haber, Adam L., Jagadeesh, Karthik, Vickovic, Sanja, Yao, Junmei, Stevens, Christine, Dionne, Danielle, Nguyen, Lan T., Villani, Alexandra-Chloé, Hofree, Matan, Creasey, Elizabeth A., Huang, Hailiang, Rozenblatt-Rosen, Orit, Garber, John J., Khalili, Hamed, Desch, A. Nicole, Daly, Mark J., Ananthakrishnan, Ashwin N., Shalek, Alex K., Xavier, Ramnik J., Regev, Aviv

“…Genome-wide association studies (GWAS) have revealed risk alleles for ulcerative colitis (UC). To understand their cell type specificities and pathways of…”
Get full text

Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection by Kazer, Samuel W., Aicher, Toby P., Muema, Daniel M., Carroll, Shaina L., Ordovas-Montanes, Jose, Miao, Vincent N., Tu, Ang A., Ziegler, Carly G. K., Nyquist, Sarah K., Wong, Emily B., Ismail, Nasreen, Dong, Mary, Moodley, Amber, Berger, Bonnie, Love, J. Christopher, Dong, Krista L., Leslie, Alasdair, Ndhlovu, Zaza M., Ndung’u, Thumbi, Walker, Bruce D., Shalek, Alex K.

“…Cellular immunity is critical for controlling intracellular pathogens, but individual cellular dynamics and cell–cell cooperativity in evolving human immune…”
Get full text

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells by Pae, Juhee, Ersching, Jonatan, Castro, Tiago B R, Schips, Marta, Mesin, Luka, Allon, Samuel J, Ordovas-Montanes, Jose, Mlynarczyk, Coraline, Melnick, Ari, Efeyan, Alejo, Shalek, Alex K, Meyer-Hermann, Michael, Victora, Gabriel D

“…During affinity maturation, germinal center (GC) B cells alternate between proliferation and somatic hypermutation in the dark zone (DZ) and affinity-dependent…”
Get full text

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells by Lafaille, Fabien G., Pessach, Itai M., Zhang, Shen-Ying, Ciancanelli, Michael J., Herman, Melina, Abhyankar, Avinash, Ying, Shui-Wang, Keros, Sotirios, Goldstein, Peter A., Mostoslavsky, Gustavo, Ordovas-Montanes, Jose, Jouanguy, Emmanuelle, Plancoulaine, Sabine, Tu, Edmund, Elkabetz, Yechiel, Al-Muhsen, Saleh, Tardieu, Marc, Schlaeger, Thorsten M., Daley, George Q., Abel, Laurent, Casanova, Jean-Laurent, Studer, Lorenz, Notarangelo, Luigi D.

“…Neurons and oligodendrocytes differentiated from induced pluripotent stem cells (iPSCs) of patients with inherited TLR3 and UNC-93B deficiencies are found to…”
Get full text

Navigating COVID-19: Starting a lab during the pandemic by Ordovás-Montañés, José, Gerlach, Carmen, Moraes-Vieira, Pedro, Vento-Tormo, Roser, Zhang, Conggang, Jurado, Kellie Ann

“…For new principal investigators, the first years are key to getting a laboratory off the ground and running. COVID-19 has changed the world, bringing on…”
Get full text

Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation by Dwyer, Daniel F, Ordovas-Montanes, Jose, Allon, Samuel J, Buchheit, Kathleen M, Vukovic, Marko, Derakhshan, Tahereh, Feng, Chunli, Lai, Juying, Hughes, Travis K, Nyquist, Sarah K, Giannetti, Matthew P, Berger, Bonnie, Bhattacharyya, Neil, Roditi, Rachel E, Katz, Howard R, Nawijn, Martijn C, Berg, Marijn, van den Berge, Maarten, Laidlaw, Tanya M, Shalek, Alex K, Barrett, Nora A, Boyce, Joshua A

“…Mast cells (MCs) play a pathobiologic role in type 2 (T2) allergic inflammatory diseases of the airway, including asthma and chronic rhinosinusitis with nasal…”
Get more information

A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers by Martin-Gayo, Enrique, Cole, Michael B, Kolb, Kellie E, Ouyang, Zhengyu, Cronin, Jacqueline, Kazer, Samuel W, Ordovas-Montanes, Jose, Lichterfeld, Mathias, Walker, Bruce D, Yosef, Nir, Shalek, Alex K, Yu, Xu G

“…Human immunity relies on the coordinated responses of many cellular subsets and functional states. Inter-individual variations in cellular composition and…”
Get full text