Search Results - "Montaña, Angel M"

The rational design of anticancer platinum complexes: the importance of the structure-activity relationship by Montaña, Angel M, Batalla, Consuelo

“…The ideal drug discovery process of new platinum based drugs should take into account three basic fundaments: on one side the mechanisms of action and the…”
Get more information

Synthetic methodology to prepare polysubstituted 2-aminopyrans. Synthesis of the C32–C38 subunit of immunosuppressant sanglifehrin A by Montaña, Ángel M., Barcia, Joan, Corominas, Albert

“…Pyranic hemiaminal synthons are present in natural and unnatural products with biological activity. Here a synthetic pathway to prepare this type of…”
Get full text

Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound by Montaña, Ángel M., Lorenzo, Julia, Ponzano, Stefano, Sanasi, Maria-Filomena

“…[Display omitted] This article describes the design, synthesis and biological evaluation of a new family of antitumor agents having the 1,7-epoxycyclononane…”
Get full text

The molecular shape and the field similarities as criteria to interpret SAR studies for fragment-based design of platinum(IV) anticancer agents. Correlation of physicochemical properties with cytotoxicity by Lorenzo, Julia, Montaña, Ángel M

“…Molecular shape similarity and field similarity have been used to interpret, in a qualitative way, the structure-activity relationships in a selected series of…”
Get full text

Synthesis of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products by Montaña, Ángel M, Ponzano, Stefano, Sanasi, Maria-Filomena, Kociok-Köhn, Gabriele

“…The present work deals with the synthesis of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products like physalins, with potential as…”
Get more information

Design, synthesis and SAR studies of novel 1,2-bis(aminomethyl)cyclohexane platinum(II) complexes with cytotoxic activity. Studies of interaction with DNA of iodinated seven-membered 1,4-diaminoplatinocycles by Gay, Marina, Montaña, Ángel M., Batalla, Consuelo, Mesas, Juan M., Alegre, María-Teresa

“…A selected library of nine novel platinum(II) complexes having differently functionalized 1,2-bis(aminomethyl)cyclohexane carrier ligands with a 1,4-diamino…”
Get full text

Approach to a new model of induction of stereoselectivity in the Nicholas reaction via a chiral 1-alkoxy-propargylium cation by Montaña, Angel M, Cano, Montserrat

“…A systematic study on the syn– anti diastereoselectivity of the Nicholas reaction between enantiopure propargyl acetal dicobalt–hexacarbonyl complexes, as…”
Get full text

Regio- and Stereoselective Synthesis of Acetallic Tetrahydropyrans as Building Blocks for Natural Products Preparation, via a Tandem [4+3]-Cycloaddition/Ozonolysis Process by Montaña, Ángel M., Corominas, Albert, Chesa, Juan F., García, Francisca, Font-Bardia, Mercè

“…A highly versatile synthetic pathway is presented for the preparation of polyfunctionalized acetallic tetrahydropyrans from conveniently substituted…”
Get full text

Synthesis, biological evaluation and SAR studies of novel bicyclic antitumor platinum(IV) complexes by Lorenzo, Julia, Delgado, Aida, Montaña, Ángel M., Mesas, Juan M., Alegre, María-Teresa, Rodríguez, María del Carmen, Avilés, Francesc-Xavier

“…The present study describes the synthesis, anticancer activity and SAR studies of novel platinum(IV) complexes having 1,2-bis(aminomethyl)carbobicyclic or…”
Get full text

Unprecedented double benzylic rearrangement: regio- and stereospecific tandem 1,4-shift and Curtin rearrangement by Montaña, Ángel M., Ponzano, Stefano, Batalla, Consuelo, Font-Bardia, Mercè

“…An α-benzyloxyketone forming part of a strained cyclopentane carbon framework when treated with 10equiv of anhydrous NaOH in absolute ethanol, for 2h, affords…”
Get full text

[4+3] Cycloaddition of C-3 substituted furans. Stereoselectivity induced by coordination effects by Montaña, Ángel M., Grima, Pedro M., Castellví, María, Batalla, Consuelo, Font-Bardia, Mercè

“…Several C-3 substituted furans with chelating groups have been reacted with 2,3-dibromo-3-pentanone in the presence of a reducing metal, resulting in the…”
Get full text

Versatile Methodology to Hydrate Alkynes, in the Presence of a Wide Variety of Functional Groups, with Mercury(II) p-Toluensulfonamidate, Under Catalytic, Mild, and Neutral Conditions by Corominas, Albert, Montaña, Ángel M.

“…A method to generate carbonylic compounds from alkynes under mild and neutral conditions, with excellent functional group compatibility and good yields, is…”
Get full text

Synthesis, characterization and antiproliferative studies of the enantiomers of cis-[(1,2-camphordiamine)dichloro]platinum(II) complexes by Montaña, Ángel M., Bernal, Francisco J., Lorenzo, Julia, Farnós, Carlos, Batalla, Consuelo, Prieto, Maria J., Moreno, Virtudes, Avilés, Francesc X., Mesas, Juan M., Alegre, María-Teresa

“…The platinum(II) complex ( 1) and its enantiomer ( 2) have been synthesized in four steps, starting from (1 S)- and (1 R)-camphorquinone, respectively. The…”
Get full text

Synthesis, Biophysical Studies, and Antiproliferative Activity of Platinum(II) Complexes Having 1,2-Bis(aminomethyl)carbobicyclic Ligands by de Mier-Vinué, Jordi, Gay, Marina, Montaña, Ángel M, Sáez, Rosa-Isabel, Moreno, Virtudes, Kasparkova, Jana, Vrana, Oldrich, Heringova, Pavla, Brabec, Viktor, Boccarelli, Angela, Coluccia, Mauro, Natile, Giovanni

“…A selected chemical library of six platinum(II) complexes having 1,2-bis(aminomethyl)carbobicyclic ligands were synthesized after a rational design in order to…”
Get full text

The σ and π Holes. The Halogen and Tetrel Bondings: Their Nature, Importance and Chemical, Biological and Medicinal Implications by Montaña, Ángel M.

“…The non‐covalent halogen bonding, or simply halogen bonding, is known since last century and it was slightly explored by several scientists in the fifties…”
Get full text

Study of cis/trans and endo/exo Diastereoselectivity in the [4+3]-Cycloaddition Reaction of 2-Functionalized Furans and Dimethyloxyallyl Cation: Preparation of Versatile Cycloheptane Synthons by Montaña, Angel M, Ribes, Sandra, Grima, Pedro M, García, Francisca

“…A study on the influence of steric and electronic effects of a function attached at C-2 of furans in the yield and diastereoselectivity of [4+3] cycloaddition…”
Get full text

Synthesis of 2,6-dioxatricyclo[3.3.1.03,7]nonanes by intramolecular haloetherification and/or transannular hydroxycyclization of alkenes in [4+3]-cycloadducts by Montaña, Ángel M., Barcia, Juan A., Kociok-Köhn, Gabriele, Font-Bardía, Mercè

“…The synthesis of new difunctionalized 2,6-dioxatricyclo[3.3.1.03,7]nonanes is described. This type of structure is an interesting synthetic building block for…”
Get full text

Synthesis, DNA interaction and cytotoxicity studies of cis-{[1, 2-bis(aminomethyl)cyclohexane]dihalo}platinum(II) complexes by Mier-Vinué, Jordi de, Lorenzo, Julia, Montaña, Ángel M., Moreno, Virtudes, Avilés, Francesc X.

“…A series of platinum compounds with an analogue structure to cisplatin have been synthesized and their biological activity against HL-60 cancer cell line has…”
Get full text

Asymmetry induction on the [4C(4π)+3C(2π)] cycloaddition reaction of C2-functionalized furans: influence of the chiral auxiliary nature by Montaña, Angel M, Grima, Pedro M

“…The study of the π-facial diastereoselectivity in the [4+3] cycloaddition reaction of thirteen different chiral 2-substituted furans with oxyallyl cations,…”
Get full text

Induction of asymmetry on the [4+3] cycloaddition reaction of C2-functionalized furans by Montaña, Angel M, Grima, Pedro M

“…A study of the induction of asymmetry on the [4+3] cycloaddition reaction of some 13 C2-substituted furan derivatives with 2-oxyallyl cation is presented. The…”
Get full text