Search Results - "Montaña, Ángel M."

The rational design of anticancer platinum complexes: the importance of the structure-activity relationship by Montaña, Angel M, Batalla, Consuelo

“…The ideal drug discovery process of new platinum based drugs should take into account three basic fundaments: on one side the mechanisms of action and the…”
Get more information

Synthetic methodology to prepare polysubstituted 2-aminopyrans. Synthesis of the C32–C38 subunit of immunosuppressant sanglifehrin A by Montaña, Ángel M., Barcia, Joan, Corominas, Albert

“…Pyranic hemiaminal synthons are present in natural and unnatural products with biological activity. Here a synthetic pathway to prepare this type of…”
Get full text

Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound by Montaña, Ángel M., Lorenzo, Julia, Ponzano, Stefano, Sanasi, Maria-Filomena

“…[Display omitted] This article describes the design, synthesis and biological evaluation of a new family of antitumor agents having the 1,7-epoxycyclononane…”
Get full text

The molecular shape and the field similarities as criteria to interpret SAR studies for fragment-based design of platinum(IV) anticancer agents. Correlation of physicochemical properties with cytotoxicity by Lorenzo, Julia, Montaña, Ángel M

“…Molecular shape similarity and field similarity have been used to interpret, in a qualitative way, the structure-activity relationships in a selected series of…”
Get full text

Synthesis of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products by Montaña, Ángel M, Ponzano, Stefano, Sanasi, Maria-Filomena, Kociok-Köhn, Gabriele

“…The present work deals with the synthesis of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products like physalins, with potential as…”
Get more information

Design, synthesis and SAR studies of novel 1,2-bis(aminomethyl)cyclohexane platinum(II) complexes with cytotoxic activity. Studies of interaction with DNA of iodinated seven-membered 1,4-diaminoplatinocycles by Gay, Marina, Montaña, Ángel M., Batalla, Consuelo, Mesas, Juan M., Alegre, María-Teresa

“…A selected library of nine novel platinum(II) complexes having differently functionalized 1,2-bis(aminomethyl)cyclohexane carrier ligands with a 1,4-diamino…”
Get full text

Regio- and Stereoselective Synthesis of Acetallic Tetrahydropyrans as Building Blocks for Natural Products Preparation, via a Tandem [4+3]-Cycloaddition/Ozonolysis Process by Montaña, Ángel M., Corominas, Albert, Chesa, Juan F., García, Francisca, Font-Bardia, Mercè

“…A highly versatile synthetic pathway is presented for the preparation of polyfunctionalized acetallic tetrahydropyrans from conveniently substituted…”
Get full text

Unprecedented double benzylic rearrangement: regio- and stereospecific tandem 1,4-shift and Curtin rearrangement by Montaña, Ángel M., Ponzano, Stefano, Batalla, Consuelo, Font-Bardia, Mercè

“…An α-benzyloxyketone forming part of a strained cyclopentane carbon framework when treated with 10equiv of anhydrous NaOH in absolute ethanol, for 2h, affords…”
Get full text

[4+3] Cycloaddition of C-3 substituted furans. Stereoselectivity induced by coordination effects by Montaña, Ángel M., Grima, Pedro M., Castellví, María, Batalla, Consuelo, Font-Bardia, Mercè

“…Several C-3 substituted furans with chelating groups have been reacted with 2,3-dibromo-3-pentanone in the presence of a reducing metal, resulting in the…”
Get full text

Versatile Methodology to Hydrate Alkynes, in the Presence of a Wide Variety of Functional Groups, with Mercury(II) p-Toluensulfonamidate, Under Catalytic, Mild, and Neutral Conditions by Corominas, Albert, Montaña, Ángel M.

“…A method to generate carbonylic compounds from alkynes under mild and neutral conditions, with excellent functional group compatibility and good yields, is…”
Get full text

The σ and π Holes. The Halogen and Tetrel Bondings: Their Nature, Importance and Chemical, Biological and Medicinal Implications by Montaña, Ángel M.

“…The non‐covalent halogen bonding, or simply halogen bonding, is known since last century and it was slightly explored by several scientists in the fifties…”
Get full text

Synthesis of 2,6-dioxatricyclo[3.3.1.03,7]nonanes by intramolecular haloetherification and/or transannular hydroxycyclization of alkenes in [4+3]-cycloadducts by Montaña, Ángel M., Barcia, Juan A., Kociok-Köhn, Gabriele, Font-Bardía, Mercè

“…The synthesis of new difunctionalized 2,6-dioxatricyclo[3.3.1.03,7]nonanes is described. This type of structure is an interesting synthetic building block for…”
Get full text

Synthesis, DNA interaction and cytotoxicity studies of cis-{[1, 2-bis(aminomethyl)cyclohexane]dihalo}platinum(II) complexes by Mier-Vinué, Jordi de, Lorenzo, Julia, Montaña, Ángel M., Moreno, Virtudes, Avilés, Francesc X.

“…A series of platinum compounds with an analogue structure to cisplatin have been synthesized and their biological activity against HL-60 cancer cell line has…”
Get full text

Synthesis of 3-Aminotropones from N-Boc-Protected Furan-2-amine (=tert-Butyl Furan-2-ylcarbamate; Boc=(tert-Butoxy)carbonyl) by Cycloaddition Reactions and Subsequent Rearrangement by Montaña, Ángel M., Barcia, Juan A., Kociok-Köhn, Gabriele, Font-Bardia, Mercè, Solans, Xavier

“…The 3‐aminotropones (=3‐aminocyclohepta‐2,4,6‐trien‐1‐ones) 4 were prepared in two steps by i) a [4+3] cycloaddition reaction between a conveniently…”
Get full text

New methodology for the synthesis of tetrahydrofuro[3,2-b]furan-2(3H)-one derivatives, synthons of natural products with biological interest by Montaña, Ángel M., Barcia, Joan A., Grima, Pedro M., Kociok-Köhn, Gabriele

“…A new methodology is presented to synthesize in a regio and stereoselective manner tetrahydrofuro[3,2-b]furan-2(3H)-one, structural subunit present in a wide…”
Get full text

Use of the p-Tolylsulfinyl Group as a Chiral Inductor in Stereoselective [4+3] Cycloaddition Reactions: Preparation of Enantiopure Polysubstituted 8-Oxabicyclo[3.2.1]oct-6-en-3-one Systems Having up to Five Stereocenters by Montaña, Ángel M., Grima, Pedro M., Batalla, Consuelo, Sanz, Francisca, Kociok-Köhn, Gabriele

“…The use of the p‐tolylsulfinyl group as a chiral inductor in stereoselective [4+3] cycloaddition reactions has made possible the preparation of enantiopure…”
Get full text

Synthesis of C3-substituted enantiopure 2-(p-tolylsulfinyl)-furans: the sulfoxide group as a chiral inductor for furan dienes as precursors of a wide variety of chiral intermediates by Montaña, Ángel M., Grima, Pedro M., Batalla, Consuelo, Kociok-Köhn, Gabriele

“…(−)-(1R,2S,5R)-Menthyl (SS)-p-toluenesulfinate and its enantiomer are a common source for a chiral sulfoxide group in organic synthesis, by means of…”
Get full text

Synthesis of 1,7-epoxycyclononanes and 1,8-epoxycyclodecanes by β-fragmentation reactions using LTA and I 2 by Montaña, Ángel M., Ponzano, Stefano

“…The treatment of derivatives on C3 of 6-hydroxy-2,7-dimethyl-11-oxatricyclo[6.2.1.0 2,6]undecan-4-one with lead tetraacetate and iodine, gave, in a good yield,…”
Get full text

Versatile Methodology to Synthesize Oxygen-Bridged Nine- and Ten-Membered Cycloalkanes by the Hypoiodite Reaction by Montaña, Ángel M., Ponzano, Stefano, Kociok-Köhn, Gabriele, Font-Bardia, Mercè, Solans, Xavier

“…C‐3 derivatives of 6‐hydroxy‐2,7‐dimethyl‐11‐oxatricyclo[6.2.1.02,6]undecan‐4‐one reacted with lead tetraacetate (LTA) and iodine to afford, in good yield,…”
Get full text

Studies of interaction of dichloro[η 2-dimethyl-(2-methylidene-cyclohexylmethyl)-amino]platinum(II) with DNA: Effects on secondary and tertiary structures of DNA – Cytotoxic assays on human cancer cell lines Capan 1 and A431 by Gay, Marina, Montaña, Ángel M., Moreno, Virtudes, Prieto, Marı́a-José, Llorens, Rafael, Ferrer, Laura

“…The interaction with DNA and the cytotoxic activity of a new organometallic platinum(II) compound were studied. Different techniques were used to evaluate…”
Get full text