Search Results - "Monsigny, M"

Transcription of plasmid DNA: Influence of plasmid DNA/polyethylenimine complex formation by Honoré, Isabelle, Grosse, Stéphanie, Frison, Natacha, Favatier, Florence, Monsigny, Michel, Fajac, Isabelle

“…Polyethylenimine (PEI) is one of the most potent non-viral vectors. We have developed a lactosylated PEI (Lac-PEI) to enhance cell-specific transfection and…”
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Carbohydrate-lectin interactions assessed by surface plasmon resonance by Duverger, Eric, Frison, Natacha, Roche, Annie-Claude, Monsigny, Michel

“…The specificity, the strength, the kinetics and some thermodynamic parameters of sugar-protein interactions are easily assessed by surface plasmon resonance…”
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Potocytosis and cellular exit of complexes as cellular pathways for gene delivery by polycations by Grosse, Stéphanie, Aron, Yolande, Thévenot, Guiti, François, Dominique, Monsigny, Michel, Fajac, Isabelle

“…Background Although polycations are among the most efficient nonviral vectors for gene transfer, the gene expression they allow is still too low for in vivo…”
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Glycofection: facilitated gene transfer by cationic glycopolymers by Roche, A. C, Fajac, I, Grosse, S, Frison, N, Rondanino, C, Mayer, R, Monsigny, M

“…Mammalian cells express several types of lectins involved in intracellular trafficking, including endocytosis, interorganelle routing and putatively nuclear…”
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Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes by Grosse, Stéphanie, Aron, Yolande, Honoré, Isabelle, Thévenot, Guiti, Danel, Claire, Roche, Annie-Claude, Monsigny, Michel, Fajac, Isabelle

“…Background As we have previously shown that lactosylated polyethylenimine (PEI) is the most efficient glycosylated PEI for gene transfer into human airway…”
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Targeting of cell receptors and gene transfer efficiency: a balancing act by FAJAC, I, GROSSE, S, BRIAND, P, MONSIGNY, M

“…Vectors conjugated with ligands recognized by cell surface receptors are of interest for cystic fibrosis gene therapy since these vectors would allow…”
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ERGIC-53 is a functional mannose-selective and calcium-dependent human homologue of leguminous lectins by Itin, C, Roche, A C, Monsigny, M, Hauri, H P

“…Based on sequence homologies with leguminous lectins, the intermediate compartment marker ERGIC-53 was proposed to be a member of a putative new class of…”
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Sugar-dependent nuclear import of glycosylated proteins in living cells by Rondanino, Christine, Bousser, Marie-Thérèse, Monsigny, Michel, Roche, Annie-Claude

“…The nuclear import of proteins larger than Mr 40,000 depends on the presence of a nuclear localization signal (NLS) corresponding either to a short peptide…”
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Glycosylated Polylysine/DNA Complexes: Gene Transfer Efficiency in Relation with the Size and the Sugar Substitution Level of Glycosylated Polylysines and with the Plasmid Size by Erbacher, Patrick, Roche, Annie Claude, Monsigny, Michel, Midoux, Patrick

“…A DNA delivery system based on the use of polylysine substituted with small recognition signals, such as carbohydrate moieties specifically recognized by…”
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Galectin-3 expression in human atherosclerotic lesions by Nachtigal, M, Al-Assaad, Z, Mayer, EP, Kim, K, Monsigny, M

“…The expression of galectin-3, a beta-galactoside-binding lectin, was studied in atherosclerotic lesions from specimens obtained from carotid endarterectomies,…”
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The Tat protein of HIV-1 induces galectin-3 expression by Fogel, Séverine, Guittaut, Michael, Legrand, Alain, Monsigny, Michel, Hébert, Eric

“…Animal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates. Galectin-3 is a β-galactoside-binding lectin…”
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Targeting of cell receptors and gene transfer efficiency: a balancing act by Fajac, I, Grosse, S, Briand, P, Monsigny, M

“…Vectors conjugated with ligands recognized by cell surface receptors are of interest for cystic fibrosis gene therapy since these vectors would allow…”
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Enhanced biological activity of antisense oligonucleotides complexed with glycosylated poly-L-lysine by Stewart, A J, Pichon, C, Meunier, L, Midoux, P, Monsigny, M, Roche, A C

“…We sought to exploit glycosylated poly-L-lysine (pLK) to increase the uptake and biological antisense activity of a phosphorothioate oligonucleotide (pt-odn)…”
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The second intron of the human galectin-3 gene has a strong promoter activity down-regulated by p53 by Raimond, Jacques, Rouleux, Florence, Monsigny, Michel, Legrand, Alain

“…Galectin-3 is a galactose-specific lectin which has been shown to be involved in several biological functions such as cell growth regulation, cell aggregation…”
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Delivery of oligonucleotides into mammalian cells by anionic peptides: comparison between monomeric and dimeric peptides by Freulon, I, Roche, A C, Monsigny, M, Mayer, R

“…The use of antisense oligonucleotides as putative therapeutic agents is limited by their poor delivery into the cytosol and/or the nucleus because they are not…”
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Glycotargeting: The preparation of glyco-amino acids and derivatives from unprotected reducing sugars by Monsigny, M., Quétard, C., Bourgerie, S., Delay, D., Pichon, C., Midoux, P., Mayer, R., Roche, A.C.

“…▪ present on the surface of many cells. Many lectins actively recycle from membrane to endosomes and efficiently take up glycoconjugates in a sugar-dependent…”
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Sugar-lectin interactions: sugar clusters, lectin multivalency and avidity by Monsigny, M, Mayer, R, Roche, A C

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The nuclear export signal-dependent localization of oligonucleopeptides enhances the inhibition of the protein expression from a gene transcribed in cytosol by Meunier, L., Mayer, R., Monsigny, M., Roche, A. C.

“…Upon endocytosis, most oligodeoxynucleotides (ODNs) accumulate in vesicular compartments; a tiny number of them cross the vesicle membrane, reach the cytosol…”
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Ultraviolet Rays Induced Expression of Lectins on the Surface of a Squamous Carcinoma Keratinocyte Cell Line by Condaminet, B., Redziniak, G., Monsigny, M., Kieda, C.

“…Human keratinocytic cells from squamous carcinoma (SCL-1) present, under resting conditions, relatively low amounts of endogenous lectins (sugar-binding…”
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New human microvascular endothelial cell lines with specific adhesion molecules phenotypes by Kieda, C, Paprocka, M, Krawczenko, A, Załecki, P, Dupuis, P, Monsigny, M, Radzikowski, C, Duś, D

“…Vascular endothelial cells recognize blood-borne circulating cells and allow them to extravasate in a tissue-specific manner. Because this property determines…”
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