Search Results - "Monsen, Robert C."

Higher-order G-quadruplexes in promoters are untapped drug targets by Monsen, Robert C

“…G-quadruplexes (G4s) are four-stranded nucleic acid secondary structures that form within guanine-rich regions of chromatin. G4 motifs are abundant in the…”
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The hTERT core promoter forms three parallel G-quadruplexes by Monsen, Robert C, DeLeeuw, Lynn, Dean, William L, Gray, Robert D, Sabo, T Michael, Chakravarthy, Srinivas, Chaires, Jonathan B, Trent, John O

“…The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT promoter is disputed. One model features a structure with three…”
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Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex by Monsen, Robert C, Maguire, Jon M, DeLeeuw, Lynn W, Chaires, Jonathan B, Trent, John O

“…DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified…”
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POT1 stability and binding measured by fluorescence thermal shift assays by DeLeeuw, Lynn W, Monsen, Robert C, Petrauskas, Vytautas, Gray, Robert D, Baranauskiene, Lina, Matulis, Daumantas, Trent, John O, Chaires, Jonathan B

“…The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end…”
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G‑quadruplex DNA: A Longer Story by Monsen, Robert C., Trent, John O., Chaires, Jonathan B.

“…Conspectus G-quadruplexes (G4s) are distinctive four-stranded DNA or RNA structures found within cells that are thought to play functional roles in gene…”
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G-quadruplex virtual drug screening: A review by Monsen, Robert C., Trent, John O.

“…Over the past two decades biologists and bioinformaticians have unearthed substantial evidence supporting a role for G-quadruplexes as important mediators of…”
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The solution structures of higher-order human telomere G-quadruplex multimers by Monsen, Robert C, Chakravarthy, Srinivas, Dean, William L, Chaires, Jonathan B, Trent, John O

“…Abstract Human telomeres contain the repeat DNA sequence 5′-d(TTAGGG), with duplex regions that are several kilobases long terminating in a 3′ single-stranded…”
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Strategy for modeling higher-order G-quadruplex structures recalcitrant to NMR determination by Michael Sabo, T., Trent, John O., Chaires, Jonathan B., Monsen, Robert C.

“…•NMR is the gold standard for determining the solution structures of G-quadruplexes.•Higher-order G-quadruplexes (xG4s) are often not amenable to…”
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Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences by Monsen, Robert C, DeLeeuw, Lynn W, Dean, William L, Gray, Robert D, Chakravarthy, Srinivas, Hopkins, Jesse B, Chaires, Jonathan B, Trent, John O

“…Abstract We report on higher-order G-quadruplex structures adopted by long promoter sequences obtained by an iterative integrated structural biology approach…”
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Structure of a 28.5 kDa duplex-embedded G-quadruplex system resolved to 7.4 Å resolution with cryo-EM by Monsen, Robert C, Chua, Eugene Y D, Hopkins, Jesse B, Chaires, Jonathan B, Trent, John O

“…Genomic regions with high guanine content can fold into non-B form DNA four-stranded structures known as G-quadruplexes (G4s). Extensive in vivo investigations…”
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Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation by Dean, William L, Gray, Robert D, DeLeeuw, Lynn, Monsen, Robert C, Chaires, Jonathan B

“…Analytical ultracentrifugation is a powerful biophysical tool that provides information about G-quadruplex structure, stability, and binding reactivity. This…”
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Structural characterization and targeting of higher-order promoter G-quadruplexes by Monsen, Robert C., DeLeeuw, Lynn W., Dean, William L., Gray, Robert D., Chakravarthy, Srinivas, Hopkins, Jesse B., Chaires, Jonathan B., Trent, John O.

“…Abstract only…”
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Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex by Robert C Monsen, Jon M Maguire, Lynn W DeLeeuw, Jonathan B Chaires, John O Trent

“…DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified…”
Get full text