Search Results - "Monroy, Nancy"
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Candidate pharmacological treatments for substance use disorder and suicide identified by gene co‐expression network‐based drug repositioning
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01-04-2021)“…Patients with substance use disorders (SUD) are at high risk to die by suicide. So far, the neurobiology of the suicide‐SUD association has not been…”
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Alcohol intake potentiates clozapine adverse effects associated to CYP1A21C in patients with refractory psychosis
Published in Drug development research (01-08-2021)“…Clozapine (CLZ) is an atypical antipsychotic and the gold standard for refractory psychosis treatment. However, there is little information regarding…”
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Analyzing leukocyte telomere length in bipolar disorder
Published in Revista brasileira de psiquiatria (01-07-2017)Get full text
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Establishment of induced pluripotent stem cell lines derived from Parkinson’s disease Mexican patients: A sporadic (UNAMi002-A) and a familial (UNAMi003-A) case carrying a mutation in PINK1
Published in Stem cell research (01-04-2024)“…Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results in a prominent…”
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Generation of a human induced pluripotent stem cell line (UNAMi001-A) from a Mexican patient with sporadic Parkinson’s disease
Published in Stem cell research (01-12-2022)“…Parkinson’s disease (PD) is a neurodegenerative disease caused by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which results…”
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Integrative Genomic-Epigenomic Analysis of Clozapine-Treated Patients with Refractory Psychosis
Published in Pharmaceuticals (Basel, Switzerland) (04-02-2021)“…Clozapine (CLZ) is the only antipsychotic drug that has been proven to be effective in patients with refractory psychosis, but it has also been proposed as an…”
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Clozapine Long-Term Treatment Might Reduce Epigenetic Age Through Hypomethylation of Longevity Regulatory Pathways Genes
Published in Frontiers in psychiatry (18-05-2022)“…Long-term studies have shown significantly lower mortality rates in patients with continuous clozapine (CLZ) treatment than other antipsychotics. We aimed to…”
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High frequency of Parkin exon rearrangements in Mexican-mestizo patients with early-onset Parkinson's disease
Published in Movement disorders (01-07-2012)“…Background: Parkin mutations in patients with early‐onset Parkinson's disease (EOPD) are estimated to occur in 49% of familial cases and 18% of sporadic cases…”
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Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans
Published in Clinical pharmacology and therapeutics (01-01-2020)“…We present the distribution of CYP2D6, CYP2C9, and CYP2C19 variants and predicted phenotypes in 33 native and admixed populations from Ibero‐America…”
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High penetrance of EDA pathogenic variants in Mexican female carriers with hypohidrotic ectodermal dysplasia
Published in Dermatologica Sinica (01-07-2020)“…X-linked hypohidrotic ectodermal dysplasia (XLHED) is caused by EDA pathogenic variants. Female carriers show several clinical manifestations in variable…”
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Genetic mutations in early-onset Parkinson's disease Mexican patients: Molecular testing implications
Published in American journal of medical genetics. Part B, Neuropsychiatric genetics (01-04-2014)“…Mutations in PARK2, PINK1, and DJ‐1 have been associated with autosomal recessive early‐onset Parkinson's disease. Here, we report the prevalence of sequence…”
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72 EXPLORATORY ANALYSIS OF SEX DIFFERENCES IN BRAIN GENE EXPRESSION IN SUICIDES
Published in European neuropsychopharmacology (01-10-2019)Get full text
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Fabry disease, differential diagnosis or coexistence with multiple sclerosis? A new mutation identified
Published in Molecular genetics and metabolism (01-02-2020)Get full text
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Synaptotagmin XI in Parkinson's disease: New evidence from an association study in Spain and Mexico
Published in Journal of the neurological sciences (15-03-2016)“…Abstract Introduction The pathophysiology of PD (Parkinson's disease) has been related to the ubiquitin proteasome system and oxidative stress. Parkin acts as…”
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SA113 - POSTMORTEM STUDY OF MESSENGER RNA EXPRESSION IN THE DORSOLATERAL PREFRONTAL CORTEX OF SUBJECTS WITH CONSUMMATE SUICIDE AND SUBSTANCE ABUSE
Published in European neuropsychopharmacology (2019)“…It is estimated that subjects with alcohol abuse are almost 10 times more likely to commit suicide and those with substance abuse about 14 times more. The…”
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A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy
Published in Human molecular genetics (01-11-2006)“…In eukaryotic cells, phosphoinositides are lipid second messengers important for many cellular processes and have been found dysregulated in several human…”
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Low frequency of common LRRK2 mutations in Mexican patients with Parkinson's disease
Published in Neuroscience letters (19-11-2010)“…▶ To our knowledge, this study represents the first analysis of LRRK2 mutations in PD patients and neurologically healthy controls of Mexican-mestizo…”
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Telomere length in psychiatric disorders: Is it more than an ageing marker?
Published in The world journal of biological psychiatry (31-10-2018)“…Objectives: Psychiatric and substance-use disorders have been associated with premature biological ageing. Telomere length (TL), considered an ageing marker,…”
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