Search Results - "Monroe, John G."

B-cell targeted therapies in human autoimmune diseases: an updated perspective by Townsend, Michael J, Monroe, John G, Chan, Andrew C

“…The advent of therapies that specifically target the B-lymphocyte lineage in human disease has rejuvenated interest in the mechanistic biology by which B cells…”
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Pharmacological Inhibition of MALT1 Ameliorates Autoimmune Pathogenesis and Can Be Uncoupled From Effects on Regulatory T-Cells by Biswas, Subhabrata, Chalishazar, Aditi, Helou, Ynes, DiSpirito, Joanna, DeChristopher, Brian, Chatterjee, Devin, Merselis, Leidy, Vincent, Benjamin, Monroe, John G, Rabah, Dania, Long, Andrew J

“…MALT1 forms part of a central signaling node downstream of immunoreceptor tyrosine-based activation motif (ITAM)-containing receptors, across a broad range of…”
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Fate decisions regulating bone marrow and peripheral B lymphocyte development by Monroe, John G, Dorshkind, Kenneth

“…In adult mammals, bone marrow pluripotent hematopoietic stem cells generate B lymphoid-specified progeny that progress through a series of well-characterized…”
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Transitional B cells: step by step towards immune competence by Chung, James B., Silverman, Michael, Monroe, John G.

“…Transitional B cells mark the crucial link between bone-marrow (BM) immature and peripheral mature B cells. Examination reveals unexpected heterogeneity,…”
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Early Growth Response Genes Regulate B Cell Development, Proliferation, and Immune Response by Gururajan, Murali, Simmons, Alan, Dasu, Trivikram, Spear, Brett T, Calulot, Christopher, Robertson, Darrell A, Wiest, David L, Monroe, John G, Bondada, Subbarao

“…Egr-1 (early growth response gene-1) is an immediate early gene encoding a zinc finger motif-containing transcription factor. Upon cross-linking of BCR, mature…”
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Mouse Mammary Tumor Virus Suppresses Apoptosis of Mammary Epithelial Cells through ITAM-Mediated Signaling by KIM, Hyoung H, GRANDE, Shannon M, MONROE, John G, ROSS, Susan R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses by Kobayashi, Takashi, Kim, Tae Soo, Jacob, Anand, Walsh, Matthew C, Kadono, Yuho, Fuentes-Pananá, Ezequiel, Yoshioka, Tomoko, Yoshimura, Akihiko, Yamamoto, Masahiro, Kaisho, Tsuneyasu, Akira, Shizuo, Monroe, John G, Choi, Yongwon

“…TNF receptor superfamily members, such as CD40 and the Toll-like receptors (TLRs), regulate many aspects of B cell differentiation and activation. TRAF6 is an…”
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Ligand-independent tonic signaling in B-cell receptor function by Monroe, John G

“…The random and inherently imprecise process of V(D)J recombination is the foundation for generation of the B-cell receptor (BCR). Signals must be generated to…”
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ITAM-mediated tonic signalling through pre-BCR and BCR complexes by Monroe, John G

“…Studies carried out over the past few years provide strong support for the idea that Ig alpha-Ig beta-containing complexes such as the pre-B-cell receptor and…”
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MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture by Katz, Elad, Lareef, Mohamed H, Rassa, John C, Grande, Shannon M, King, Leslie B, Russo, Jose, Ross, Susan R, Monroe, John G

“…Expression of immunoreceptor tyrosine-based activation motif (ITAM)-containing signaling proteins is normally restricted to hematopoietic tissues. The basal…”
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Negative Selection of Immature B Cells by Receptor Editing or Deletion Is Determined by Site of Antigen Encounter by Sandel, Peter C, Monroe, John G

“…Immature B cells that encounter self-antigen are eliminated from the immune repertoire by negative selection. Negative selection has been proposed to take…”
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Basal B-cell receptor signaling in B lymphocytes: mechanisms of regulation and role in positive selection, differentiation, and peripheral survival by Fuentes-Pananá, Ezequiel M., Bannish, Gregory, Monroe, John G.

“…B‐cell development is a highly ordered multistep process dependent upon signals generated by the pre‐B and B‐cell antigen receptor (BCR). BCR signals drive…”
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Membrane Cholesterol Content Accounts for Developmental Differences in Surface B Cell Receptor Compartmentalization and Signaling by Karnell, Fredrick G, Brezski, Randall J, King, Leslie B, Silverman, Michael A, Monroe, John G

“…Recent studies argue for an important role for cholesterol in maintaining plasma membrane heterogeneity and influencing a variety of cellular processes,…”
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An Immunoreceptor Tyrosine Activation Motif in the Mouse Mammary Tumor Virus Envelope Protein Plays a Role in Virus-Induced Mammary Tumors by ROSS, Susan R, SCHMIDT, John W, KATZ, Elad, CAPPELLI, Laura, HULTINE, Stacy, GIMOTTY, Phyllis, MONROE, John G

“…Author's Correction ( vol. 81 , p. 12718 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike…”
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Rapid B Cell Receptor-induced Unfolded Protein Response in Nonsecretory B Cells Correlates with Pro- Versus Antiapoptotic Cell Fate by Skalet, Alison H., Isler, Jennifer A., King, Leslie B., Harding, Heather P., Ron, David, Monroe, John G.

“…The adaptive unfolded protein response (UPR) is essential for the development of antibody-secreting plasma cells. B cells induced by lipopolysaccharide (LPS)…”
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The Role of MAPKs in B Cell Receptor-induced Down-regulation of Egr-1 in Immature B Lymphoma Cells by Ke, Jiyuan, Gururajan, Murali, Kumar, Anupam, Simmons, Alan, Turcios, Lilia, Chelvarajan, Ralph L., Cohen, David M., Wiest, David L., Monroe, John G., Bondada, Subbarao

“…Cross-linking of the B cell receptor (BCR) on the immature B lymphoma cell line BKS-2 induces growth inhibition and apoptosis accompanied by rapid…”
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Commentary: Keeping track of pro‐B cells: a new model for the effects of IL‐7 during B cell development by Monroe, John G., Allman, David

“…Trophic and instructive models have been invoked to explain how various cytokines influence the survival, proliferation and differentiation of lymphoid…”
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Oscillation between B-lymphoid and myeloid lineages in Myc-induced hematopoietic tumors following spontaneous silencing/reactivation of the EBF/Pax5 pathway by Yu, Duonan, Allman, David, Goldschmidt, Michael H., Atchison, Michael L., Monroe, John G., Thomas-Tikhonenko, Andrei

“…B lymphomagenesis is an uncontrolled expansion of immature precursors that fail to complete their differentiation program. This failure could be at least…”
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CD23 defines two distinct subsets of immature B cells which differ in their responses to T cell help signals by Chung, James B., Sater, Richard A., Fields, Michele L., Erikson, Jan, Monroe, John G.

“…Transitional immature B cells undergo apoptosis and fail to proliferate in response to BCR cross-linking, thus representing a target for negative selection of…”
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The role of early growth response gene 1 (egr-1) in regulation of the immune response by McMahon, Steven B., Monroe, John G.

“…The induction of immediate early genes in cells of the immune system is critical to determining the ultimate outcome of exposure to antigen. The importance of…”
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