Search Results - "Monroe, James J"

Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities by Podtelezhnikov, Alexei A, Monroe, James J, Aslamkhan, Amy G, Pearson, Kara, Qin, Chunhua, Tamburino, Alex M, Loboda, Andrey P, Glaab, Warren E, Sistare, Frank D, Tanis, Keith Q

“…Abstract The robust transcriptional plasticity of liver mediated through xenobiotic receptors underlies its ability to respond rapidly and effectively to…”
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Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury by Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy G B, Sistare, Frank D

“…Abstract Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted…”
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Extent of CpG methylation is not proportional to the in vivo spontaneous mutation frequency at transgenic loci in Big Blue rodents by Monroe, J J, Manjanatha, M G, Skopek, T R

“…The lacI transgene used in the Big Blue (BB) mouse and rat mutation assays typically displays spontaneous mutation frequencies in the 5x10(-5) range. Recently,…”
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Developing a T cell:Dendritic cell co-culture system to predict idiosyncratic drug induced hypersensitivity reactions by Oropallo, Michael A, Shang, Jackie, Ke, Zhenlian, Gonzalez, Raymond James, Sistare, Frank D., Lebron, Jose, Monroe, James J.

“…Abstract Idiosyncratic drug induced hypersensitivy reactions (IDHR)s pose a significant safety risk to patients. Indeed, IDHRs have been associated with…”
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Analysis of sequence alterations in a defined DNA region: comparison of temperature-modulated heteroduplex analysis and denaturing gradient gel electrophoresis by Skopek, T R, Glaab, W E, Monroe, J J, Kort, K L, Schaefer, W

“…The ability to detect DNA sequence heterogeneity quickly and reliably is becoming increasingly important as more genes involved in disease processes are…”
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Palytoxin modulates cytosolic pH in human osteoblast-like Saos-2 cells via an interaction with Na(+)-K(+)-ATPase by Monroe, J J, Tashjian, Jr, A H

“…Palytoxin (PTx) at nanomolar concentrations enhances the permeability of mammalian cell membranes to both Na+ and Ca2+. In basal human osteoblast-like Saos-2…”
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Pretreatment with 17β-Estradiol Attenuates Basal- and PTH-Stimulated Membrane Adenylyl Cyclase Activity in Human Osteoblast-like SAOS-2 Cells by Monroe, James J., Tashjian, Jr, Armen H.

“…Parathyroid hormone (PTH)-stimulated production of cAMP by intact human osteoblast-like SaOS-2 cells is diminished by pretreatment with 17β-estradiol (E2). The…”
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