Search Results - "Monopoli, Kathryn R."

Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy by Monopoli, Kathryn R., Korkin, Dmitry, Khvorova, Anastasia

“…Chemically modified small interfering RNAs (siRNAs) are promising therapeutics guiding sequence-specific silencing of disease genes. Identifying chemically…”
Get full text

Multispecies-targeting siRNAs for the modulation of JAK1 in the skin by Tang, Qi, Gross, Katherine Y., Fakih, Hassan H., Jackson, Samuel O., Zain U.I. Abideen, Mohammad, Monopoli, Kathryn R., Blanchard, Carine, Bouix-Peter, Claire, Portal, Thibaud, Harris, John E., Khvorova, Anastasia, Alterman, Julia F.

“…Identifying therapeutic oligonucleotides that are cross-reactive to experimental animal species can dramatically accelerate the process of preclinical…”
Get full text

Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs by Shmushkovich, Taisia, Monopoli, Kathryn R, Homsy, Diana, Leyfer, Dmitriy, Betancur-Boissel, Monica, Khvorova, Anastasia, Wolfson, Alexey D

“…Abstract Progress in oligonucleotide chemistry has produced a shift in the nature of siRNA used, from formulated, minimally modified siRNAs, to unformulated,…”
Get full text

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin by Tang, Qi, Fakih, Hassan H., Zain UI Abideen, Mohammad, Hildebrand, Samuel R., Afshari, Khashayar, Gross, Katherine Y., Sousa, Jacquelyn, Maebius, Allison S., Bartholdy, Christina, Søgaard, Pia Pernille, Jackerott, Malene, Hariharan, Vignesh, Summers, Ashley, Fan, Xueli, Okamura, Ken, Monopoli, Kathryn R., Cooper, David A., Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Furgal, Raymond C., Dresser, Karen, Winter, Sarah J., Biscans, Annabelle, Chuprin, Jane, Haddadi, Nazgol-Sadat, Sherman, Shany, Yıldız-Altay, Ümmügülsüm, Rashighi, Mehdi, Richmond, Jillian M., Bouix-Peter, Claire, Blanchard, Carine, Clauss, Adam, Alterman, Julia F., Khvorova, Anastasia, Harris, John E.

“…Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK…”
Get full text

Type 3 Secretion Translocators Spontaneously Assemble a Hexadecameric Transmembrane Complex by Romano, Fabian B., Tang, Yuzhou, Rossi, Kyle C., Monopoli, Kathryn R., Ross, Jennifer L., Heuck, Alejandro P.

“…A type 3 secretion system is used by many bacterial pathogens to inject proteins into eukaryotic cells. Pathogens insert a translocon complex into the target…”
Get full text

Forming the Pseudomonas Aeruginosa Translocon Requires Simultaneous Incorporation of PopB and PopD by Monopoli, Kathryn R., Heuck, Alejandro P.

Get full text