Search Results - "Mononen, N"

Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study by Kananen, L, Marttila, S, Nevalainen, T, Jylhävä, J, Mononen, N, Kähönen, M, Raitakari, O T, Lehtimäki, T, Hurme, M

“…Chronological aging-associated changes in the human DNA methylome have been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites…”
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The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies by Kananen, L., Marttila, S., Nevalainen, T., Kummola, L., Junttila, I., Mononen, N., Kähönen, M., Raitakari, O. T., Hervonen, A., Jylhä, M., Lehtimäki, T., Hurme, M., Jylhävä, J.

“…The epigenetic clock, defined as the DNA methylome age (DNAmAge), is a candidate biomarker of ageing. In this study, we aimed to characterize the behaviour of…”
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Association study of the HTR2C, leptin and adiponectin genes and serum marker analyses in clozapine treated long-term patients with schizophrenia by Klemettilä, J.-P, Kampman, O, Seppälä, N, Viikki, M, Hämäläinen, M, Moilanen, E, Mononen, N, Lehtimäki, T, Leinonen, E

“…Abstract Clozapine treatment is associated with weight gain and cardio-metabolic consequences among patients with schizophrenia. Polymorphisms of leptin,…”
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Effect of genetic polymorphisms in CA6 gene on the expression and catalytic activity of human salivary carbonic anhydrase VI by Aidar, M, Marques, Rocha, Valjakka, J, Mononen, N, Lehtimäki, T, Parkkila, S, de Souza, A P, Line, S R Peres

“…Carbonic anhydrase isoenzyme VI (CA VI) plays an important role in the homeostasis of oral tissues participating in the processes of taste, protection of…”
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The rs2516839 variation of USF1 gene is associated with 4‐year mortality of nonagenarian women: The Vitality 90+ study by Ozsait‐Selcuk, B., Komurcu‐Bayrak, E., Jylhä, M., Luukkaala, T., Perola, M., Kristiansson, K., Mononen, N., Hurme, M., Kähönen, M., Goebeler, S., Laaksonen, R., Hervonen, A., Erginel‐Unaltuna, N., Karhunen, P.J., Lehtimäki, T.

“…Upstream transcription factor 1 (USF1) regulates the transcription of many genes related to cell and organism survival processes such as stress and immune…”
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Association study of arcuate nucleus neuropeptide Y neuron receptor gene variation and serum NPY levels in clozapine treated patients with schizophrenia by Klemettilä, J.-P, Kampman, O, Solismaa, A, Lyytikäinen, L.-P, Seppälä, N, Viikki, M, Hämäläinen, M, Moilanen, E, Mononen, N, Lehtimäki, T, Leinonen, E

“…Abstract Background Antipsychotic-induced weight gain (AIWG) leads to metabolic consequences and comorbidity, social stigmatization and nonadherence in…”
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CHEK2 variants associate with hereditary prostate cancer by SEPPÄLÄ, E. H, IKONEN, T, MONONEN, N, AUTIO, V, RÖKMAN, A, MATIKAINEN, M. P, TAMMELA, T. L. J, SCHLEUTKER, J

“…Recently, variants in CHEK2 gene were shown to associate with sporadic prostate cancer in the USA. In the present study from Finland, we found that the…”
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Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects – The cardiovascular risk in young Finns study by Jaakkola, U, Kakko, T, Juonala, M, Lehtimäki, T, Viikari, J, Jääskeläinen, A.E, Mononen, N, Kähönen, M, Koskinen, T, Keltikangas-Järvinen, L, Raitakari, O, Kallio, J

“…Abstract Aims The role of neuropeptide Y (NPY) and its gene polymorphisms in the development of atherosclerosis has become increasingly evident. In asthma, NPY…”
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Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults by Komurcu-Bayrak, E, Erginel-Unaltuna, N, Onat, A, Ozsait, B, Eklund, C, Hurme, M, Mononen, N, Laaksonen, R, Hergenc, G, Lehtimäki, T

“…Abstract Objective Serum C-reactive protein (CRP) is an independent risk factor for cardiovascular disease and metabolic syndrome (MetS). The aim of this study…”
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A missense substitution A49T in the steroid 5-alpha-reductase gene ( ) is not associated with prostate cancer in Finland by MONONEN, N, IKONEN, T, SYRJÄKOSKI, K, MATIKAINEN, M, SCHLEUTKER, J, TAMMELA, T. L. J, KOIVISTO, P. A, KALLIONIEMI, O. P

“…Prostatic steroid 5-alpha-reductase gene (SRD5A2) encodes a critical enzyme involved in the conversion of testosterone to dihydrotestosterone. A germline…”
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BRCA1 and BRCA2 mutations have no major role in predisposition to prostate cancer in Finland by Ikonen, T, Matikainen, M P, Syrjäkoski, K, Mononen, N, Koivisto, P A, Rökman, A, Seppälä, E H, Kallioniemi, O-P, Tammela, T L J, Schleutker, J

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Identification of blood modular genome-wide gene expression biomarkers of cardiovascular health and depression in the young finns study by Mishra, B., Raitoharju, E., Mononen, N., Viikari, J., Juonala, M., Hutri-Kähönen, N., Kähönen, M., Raitakari, O., Lehtimäki, T., Mishra, P.

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Genetic and epigenetic regulation of nc886 RNA levels and their association to cardiometabolic phenotypes by Rajic, S., Marttila, S., Mishra, P., Mononen, N., Raitakari, O., Lyytikäinen, L.-P., Kähönen, M., Hutri-Kähönen, N., Waldenberger, M., Lehtimäki, T., Raitoharju, E.

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Regulation of NC886 RNAs is associated with cardiometabolic risk factors, death and stroke by Rajić, S., Marttila, S., Hutri-Kähönen, N., Kähönen, M., Lehtimäki, T., Lyytikäinen, L.-P., Mishra, P., Mononen, N., Raitakari, O., Waldenberger, M., Delerue, T., März, W., Kleber, M., Harville, E., Zhang, R., Raitoharju, E.

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Obesity accelerates epigenetic aging in middle-aged but not in elderly individuals by Nevalainen, Tapio, Kananen, Laura, Marttila, Saara, Jylhävä, Juulia, Mononen, Nina, Kähönen, Mika, Raitakari, Olli T, Hervonen, Antti, Jylhä, Marja, Lehtimäki, Terho, Hurme, Mikko

“…Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like…”
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5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression by Illi, Ari, Setälä-Soikkeli, Eija, Viikki, Merja, Poutanen, Outi, Huhtala, Heini, Mononen, Nina, Lehtimäki, Terho, Leinonen, Esa, Kampman, Olli

“…Genes that regulate the serotonin signalling system are potential targets for research in the aetiology of mood disorders and also in the treatment response of…”
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Germline Alterations of the RNASEL Gene, a Candidate HPC1 Gene at 1q25, in Patients and Families with Prostate Cancer by Rökman, Annika, Ikonen, Tarja, Seppälä, Eija H., Nupponen, Nina, Autio, Ville, Mononen, Nina, Bailey-Wilson, Joan, Trent, Jeffrey, Carpten, John, Matikainen, Mika P., Koivisto, Pasi A., Tammela, Teuvo L.J., Kallioniemi, Olli-P., Schleutker, Johanna

“…The RNASEL gene (2′,5′-oligoisoadenylate-synthetase dependent) encodes a ribonuclease that mediates the antiviral and apoptotic activities of interferons. The…”
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No support for a role for BDNF gene polymorphisms rs11030101 and rs61888800 in major depressive disorder or antidepressant response in patients of Finnish origin by Illi, Ari, Viikki, Merja, Poutanen, Outi, Setälä-Soikkeli, Eija, Nuolivirta, Timo, Kampman, Olli, Leinonen, Esa, Huhtala, Heini, Mononen, Nina, Lehtimäki, Terho

“…Brain-derived neurotrophic factor (BDNF) is suggested to play a role in the aetiology of major depression and in the antidepressant response in patients with…”
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Profiling genetic variation along the androgen biosynthesis and metabolism pathways implicates several single nucleotide polymorphisms and their combinations as prostate cancer risk factors by MONONEN, Nina, SEPPÄLÄ, Eija H, KALLIONIEMI, Olli, BAILEY-WILSON, Joan E, SCHLEUTKER, Johanna, DUGGAL, Priya, AUTIO, Ville, IKONEN, Tarja, ELLONEN, Pekka, SAHARINEN, Juha, SAARELA, Janna, VIHINEN, Mauno, TAMMELA, Teuvo L. J

“…Several candidate genes along androgen pathway have been suggested to affect prostate cancer risk but no single gene seems to be overwhelmingly important for a…”
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Germ-Line Alterations in MSR1 Gene and Prostate Cancer Risk by Eija H. Seppälä, Tarja Ikonen, Ville Autio, Annika Rökman, Nina Mononen, Mika P. Matikainen, Teuvo L. J. Tammela, Johanna Schleutker

“…Purpose: The MSR1 gene maps to 8p22–23, a novel susceptibility locus for hereditary prostate cancer (HPC). Mutations in MSR1 have been reported to associate…”
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