Search Results - "Monn, James"

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial by Martenyi, Ferenc, Monn, James A, Patil, Sandeep T, Zhang, Lu, Lowe, Stephen L, Jackson, Kimberley A, Andreev, Boris V, Avedisova, Alla S, Bardenstein, Leonid M, Gurovich, Issak Y, Morozova, Margarita A, Mosolov, Sergey N, Neznanov, Nikolai G, Reznik, Alexander M, Smulevich, Anatoly B, Tochilov, Vladimir A, Johnson, Bryan G, Schoepp, Darryle D

“…Schizophrenia is a chronic, complex and heterogeneous mental disorder, with pathological features of disrupted neuronal excitability and plasticity within…”
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CNS distribution of metabotropic glutamate 2 and 3 receptors: Transgenic mice and [3H]LY459477 autoradiography by Wright, Rebecca A., Johnson, Bryan G., Zhang, Ce, Salhoff, Craig, Kingston, Ann E., Calligaro, David O., Monn, James A., Schoepp, Darryle D., Marek, Gerard J.

“…Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized clinical research trials for schizophrenia and generalized anxiety…”
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Group II metabotropic glutamate receptor agonists and positive allosteric modulators as novel treatments for schizophrenia by Fell, Matthew J., McKinzie, David L., Monn, James A., Svensson, Kjell A.

“…Schizophrenia is a devastating chronic psychotic disorder characterized by positive, negative, and cognitive symptoms. Although the positive symptoms are…”
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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders by Schoepp, Darryle D, Swanson, Chad J, Bures, Mark, Johnson, Michael P, Linden, Anni-Maija, Monn, James A

“…Anxiety and stress disorders are the most commonly occurring of all mental illnesses, and current treatments are less than satisfactory. So, the discovery of…”
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Behavioural and biochemical responses to methamphetamine are differentially regulated by mGlu2 and mGlu3 metabotropic glutamate receptors in male mice by Busceti, Carla L., Ginerete, Roxana P., Di Menna, Luisa, D'Errico, Giovanna, Cisani, Francesca, Di Pietro, Paola, Imbriglio, Tiziana, Bruno, Valeria, Battaglia, Giuseppe, Fornai, Francesco, Monn, James A., Pittaluga, Anna, Nicoletti, Ferdinando

“…Group II metabotropic glutamate receptors (mGlu2 and mGlu3 receptors) shape mechanisms of methamphetamine addiction, but the individual role played by the two…”
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Structural Basis for (S)‑3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor by Chen, Qi, Ho, Joseph D, Ashok, Sheela, Vargas, Michelle C, Wang, Jing, Atwell, Shane, Bures, Mark, Schkeryantz, Jeffery M, Monn, James A, Hao, Junliang

“…(S)-3,4-Dicarboxyphenylglycine (DCPG) was first reported in 2001 as a potent orthosteric agonist with high subtype selectivity for the mGlu8 receptor, but the…”
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Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist by Monn, James A, Prieto, Lourdes, Taboada, Lorena, Hao, Junliang, Reinhard, Matthew R, Henry, Steven S, Beadle, Christopher D, Walton, Lesley, Man, Teresa, Rudyk, Helene, Clark, Barry, Tupper, David, Baker, S. Richard, Lamas, Carlos, Montero, Carlos, Marcos, Alicia, Blanco, Jaime, Bures, Mark, Clawson, David K, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xushan, Carter, Joan H, Getman, Brian G, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L

“…Identification of orthosteric mGlu2/3 receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing…”
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Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4’s group III mGlu receptor functional potency and selectivity by Schkeryantz, Jeffery M., Chen, Qi, Ho, Joseph D., Atwell, Shane, Zhang, Aiping, Vargas, Michelle C., Wang, Jing, Monn, James A., Hao, Junliang

“…[Display omitted] L-2-Amino-4-phosphonobutyric acid (L-AP4) is a known potent and selective agonist for the Group III mGlu receptors. However, it does not show…”
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Synthesis and Pharmacological Characterization of C4 β -Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu 3 Receptor Agonist by Monn, James A, Henry, Steven S, Massey, Steven M, Clawson, David K, Chen, Qi, Diseroad, Benjamin A, Bhardwaj, Rajni M, Atwell, Shane, Lu, Frances, Wang, Jing, Russell, Marijane, Heinz, Beverly A, Wang, Xu-Shan, Carter, Joan H, Getman, Brian G, Adragni, Kofi, Broad, Lisa M, Sanger, Helene E, Ursu, Daniel, Catlow, John T, Swanson, Steven, Johnson, Bryan G, Shaw, David B, McKinzie, David L, Hao, Junliang

“…Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu ) receptors, but small…”
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Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu 8 Receptor by Chen, Qi, Ho, Joseph D, Ashok, Sheela, Vargas, Michelle C, Wang, Jing, Atwell, Shane, Bures, Mark, Schkeryantz, Jeffery M, Monn, James A, Hao, Junliang

“…( S)-3,4-Dicarboxyphenylglycine (DCPG) was first reported in 2001 as a potent orthosteric agonist with high subtype selectivity for the mGlu receptor, but the…”
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In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders by RORICK-KEHN, Linda M, JOHNSON, Bryan G, SCHOEPP, Darryle D, KNITOWSKI, Karen M, SALHOFF, Craig R, WITKIN, Jeffrey M, PERRY, Kenneth W, GRIFFEY, Kelly I, TIZZANO, Joseph P, MONN, James A, MCKINZIE, David L

“…Data from both preclinical and clinical studies have provided proof of concept that modulation of limbic and forebrain glutamate, via mGlu2/3 receptor…”
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Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR by Sanger, Helen, Hanna, Lydia, Colvin, Ellen M., Grubisha, Olivera, Ursu, Daniel, Heinz, Beverly A., Findlay, Jeremy D., Vivier, Richard G., Sher, Emanuele, Lodge, David, Monn, James A., Broad, Lisa M.

“…The group II metabotropic glutamate (mGlu) receptors comprised of the mGlu2 and mGlu3 receptor subtypes have gained recognition in recent years as potential…”
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Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice by Benvenga, Mark J., Chaney, Stephen F., Baez, Melvyn, Britton, Thomas C., Hornback, William J., Monn, James A., Marek, Gerard J.

“…There is substantial evidence that glutamate can modulate the effects of 5-hydroxytryptamine 2A (5-HT 2A ) receptor activation through stimulation of…”
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In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist by Witkin, Jeffrey M., Ornstein, Paul L., Mitch, Charles H., Li, Renhua, Smith, Stephon C., Heinz, Beverly A., Wang, Xu-Shan, Xiang, Chuanxi, Carter, Joan H., Anderson, Wesley H., Li, Xia, Broad, Lisa M., Pasqui, Francesca, Fitzjohn, Stephen M., Sanger, Helen E., Smith, Jodi L., Catlow, John, Swanson, Steven, Monn, James A.

“…Metabotropic glutamate 2/3 (mGlu2/3) receptors are of considerable interest owing to their role in modulating glutamate transmission via presynaptic,…”
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Broad spectrum efficacy with LY2969822, an oral prodrug of metabotropic glutamate 2/3 receptor agonist LY2934747, in rodent pain models by Johnson, Michael P, Muhlhauser, Mark A, Nisenbaum, Eric S, Simmons, Rosa M A, Forster, Beth M, Knopp, Kelly L, Yang, Lijuan, Morrow, Denise, Li, Dominic L, Kennedy, Jeffrey D, Swanson, Steven, Monn, James A

“…Background and Purpose A body of evidence suggests activation of metabotropic glutamate 2/3 (mGlu2/3) receptors would be an effective analgesic in chronic pain…”
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mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data by Celli, Roberta, Striano, Pasquale, Citraro, Rita, Di Menna, Luisa, Cannella, Milena, Imbriglio, Tiziana, Koko, Mahmoud, Euro Epinomics-Cogie Consortium, De Sarro, Giovambattista, Monn, James A, Battaglia, Giuseppe, Luijtelaar, Gilles Van, Nicoletti, Ferdinando, Russo, Emilio, Leo, Antonio

“…Previous studies suggest that different metabotropic glutamate (mGlu) receptor subtypes are potential drug targets for treating absence epilepsy. However, no…”
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Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity by Chappell, Mark D, Li, Renhua, Smith, Stephon C, Dressman, Bruce A, Tromiczak, Eric G, Tripp, Allie E, Blanco, Maria-Jesus, Vetman, Tatiana, Quimby, Steven J, Matt, James, Britton, Thomas C, Fivush, Adam M, Schkeryantz, Jeffrey M, Mayhugh, Daniel, Erickson, Jon A, Bures, Mark G, Jaramillo, Carlos, Carpintero, Mercedes, Diego, José Eugenio de, Barberis, Mario, Garcia-Cerrada, Susana, Soriano, José F, Antonysamy, Stephen, Atwell, Shane, MacEwan, Iain, Condon, Bradley, Sougias, Christine, Wang, Jing, Zhang, Aiping, Conners, Kris, Groshong, Chris, Wasserman, Stephen R, Koss, John W, Witkin, Jeffrey M, Li, Xia, Overshiner, Carl, Wafford, Keith A, Seidel, Wesley, Wang, Xu-Shan, Heinz, Beverly A, Swanson, Steven, Catlow, John T, Bedwell, David W, Monn, James A, Mitch, Charles H, Ornstein, Paul L

“…As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the…”
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Translational Pharmacology of the Metabotropic Glutamate 2 Receptor-Preferring Agonist LY2812223 in the Animal and Human Brain by Felder, Christian C, Schober, Douglas A, Tu, Yuan, Quets, Anne, Xiao, Hongling, Watt, Marla, Siuda, Ed, Nisenbaum, Eric, Xiang, Chuanxi, Heinz, Beverly, Prieto, Lourdes, McKinzie, David L, Monn, James A

“…LY2812223 [(1 ,2 ,4 ,5 ,6 )-2-amino-4-(1 -1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid] was identified via structure-activity studies…”
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Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740 by Orlando, Rosamaria, Borro, Marina, Motolese, Marta, Molinaro, Gemma, Scaccianoce, Sergio, Caruso, Alessandra, di Nuzzo, Luigi, Caraci, Filippo, Matrisciano, Francesco, Pittaluga, Anna, Mairesse, Jerome, Simmaco, Maurizio, Nisticò, Robert, Monn, James A., Nicoletti, Ferdinando

“…LY379268 and LY354740, two agonists of mGlu2/3 metabotropic glutamate receptors, display different potencies in mouse models of schizophrenia. This…”
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Discovery of Allosteric Potentiators for the Metabotropic Glutamate 2 Receptor:  Synthesis and Subtype Selectivity of N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2− trifluoroethylsulfonyl)pyrid-3-ylmethylamine by Johnson, Michael P, Baez, Melvyn, Jagdmann, G. Erik, Britton, Thomas C, Large, Thomas H, Callagaro, David O, Tizzano, Joseph P, Monn, James A, Schoepp, Darryle D

“…This report describes recently discovered novel allosteric modulators of metabotropic glutamate2 (mGlu2) receptors. These pyridylmethylsulfonamides (e.g., 3)…”
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