Search Results - "Monks, T J"

Histone H3 phosphorylation is coupled to poly-(ADP-ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells by Tikoo, K, Lau, S S, Monks, T J

“…Although the cellular response to chemical-induced stress is relatively well characterized, particularly the response to DNA damage, factors that govern the…”
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Quinone chemistry and toxicity by Monks, T J, Hanzlik, R P, Cohen, G M, Ross, D, Graham, D G

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Serotonergic Neurotoxicity of 3,4-(±)-Methylenedioxyamphetamine and 3,4-(±)-Methylendioxymethamphetamine (Ecstasy) Is Potentiated by Inhibition of γ-Glutamyl Transpeptidase by Bai, Fengju, Jones, Douglas C, Lau, Serrine S, Monks, Terrence J

“…Reactive metabolites play an important role in 3,4-(±)-methylenedioxyamphetamine (MDA) and 3,4-(±)-methylenedioxymethamphetamine (MDMA; ecstasy)-mediated…”
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Sequential oxidation and glutathione addition to 1,4-benzoquinone: correlation of toxicity with increased glutathione substitution by Lau, S S, Hill, B A, Highet, R J, Monks, T J

“…The chemical reaction of 1,4-benzoquinone with glutathione results in the formation of adducts that exhibit increasing degrees of glutathione substitution…”
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Symposium overview: the role of glutathione in neuroprotection and neurotoxicity by Monks, T J, Ghersi-Egea, J F, Philbert, M, Cooper, A J, Lock, E A

“…Although the cytoprotective effects of glutathione (GSH) are well established, additional roles for GSH in brain function are being identified that provide a…”
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2,5- bis-(Glutathion- S-yl)-α-methyldopamine, a putative metabolite of (±)-3,4-methylenedioxyamphetamine, decreases brain serotonin concentrations by Miller, R.Timothy, Lau, Serrine S, Monks, Terrence J

“…3,4-(±)-Methylenedioxyamphetamine (MDA) and 3,4-(±)-methylenedioxymethamphetamine (MDMA) are serotonergic neurotoxicants. However, when injected directly into…”
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Role of Quinones in Toxicology by Bolton, Judy L, Trush, Michael A, Penning, Trevor M, Dryhurst, Glenn, Monks, Terrence J

“…Quinones represent a class of toxicological intermediates which can create a variety of hazardous effects in vivo, including acute cytotoxicity,…”
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Evidence for DNA damage in amyotrophic lateral sclerosis by Fitzmaurice, P S, Shaw, I C, Kleiner, H E, Miller, R T, Monks, T J, Lau, S S, Mitchell, J D, Lynch, P G

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Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-(tris-glutathion-S-yl)hydroquinone by PETERS, M. M. C. G, JONES, T. W, MONKS, T. J, LAU, S. S

“…Hydroquinone, an intermediate used in the chemical industry and a metabolite of benzene, is a nephrocarcinogen in the 2-year National Toxicology Program…”
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The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers by Monks, Terrence J, Jones, Douglas C

“…Quinones are ubiquitous in nature and constitute an important class of naturally occurring compounds found in plants, fungi and bacteria. Human exposure to…”
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Formation of catechol estrogen glutathione conjugates and γ-glutamyl transpeptidase-dependent nephrotoxicity of 17β-estradiol in the golden Syrian hamster by BUTTERWORTH, M, LAU, S. S, MONKS, T. J

“…In an animal model of hormone-mediated carcinogenesis, male golden Syrian hamsters develop renal carcinoma following prolonged exposure to 17 beta -estradiol…”
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Differential Regulation of Redox Responsive Transcription Factors by the Nephrocarcinogen 2,3,5-Tris(glutathion-S-yl)hydroquinone by Weber, Thomas J, Huang, Qihong, Monks, Terrence J, Lau, Serrine S

“…2,3,5-Tris(glutathion-S-yl)hydroquinone [TGHQ] is a potent nephrotoxicant and nephrocarcinogen, and induces a spectrum of mutations in human and bacterial…”
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Glutathione conjugates of 2-bromohydroquinone are nephrotoxic by Monks, T J, Lau, S S, Highet, R J, Gillette, J R

“…Incubation of either o-bromophenol or 2-bromohydroquinone with rat liver microsomes and 0.25 mM 35S-glutathione (GSH) gave rise to several isomeric 35S-GSH…”
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Metabolism as a determinant of species susceptibility to 2,3,5-(triglutathion-S-yl)hydroquinone-mediated nephrotoxicity. The role of N-acetylation and N-deacetylation by Lau, S S, Kleiner, H E, Monks, T J

“…2,3,5-(Triglutathion-S-yl)hydroquinone [2,3,5-(triGSyl)HQ] is a potent nephrotoxicant when administered to male rats. We now report that significant species…”
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Quinol-glutathione conjugate-induced mutation spectra in the supF gene replicated in human AD293 cells and bacterial MBL50 cells by JEONG, J. K, WOGAN, G. N, LAU, S. S, MONKS, T. J

“…Hydroquinone is a nephrocarcinogen in rats but generally tests negative in standard mutagenicity assays. However, 2,3,5-tris-(glutathion-S-yl)hydroquinone, a…”
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2-Bromo-(diglutathion-S-yl)hydroquinone nephrotoxicity: physiological, biochemical, and electrochemical determinants by Monks, T J, Highet, R J, Lau, S S

“…2-Bromo-(diglutathion-S-yl)hydroquinone [2-Br-(diGSyl)HQ] causes severe necrosis of the proximal renal tubules in the rat, elevations in blood urea nitrogen…”
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2-hydroxy-4-glutathion-S-yl-17β-estradiol and 2-hydroxy-1-glutathion-S-yl-17β-estradiol produce oxidative stress and renal toxicity in an animal model of 17β-estradiol-mediated nephrocarcinogenicity by BUTTERWORTH, M, LAU, S. S, MONKS, T. J

“…Chronic exposure of male Syrian hamsters to a variety of estrogens has been linked with a high incidence of renal carcinoma. The basis of this species and…”
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Irreversible inhibition of rat glutathione S-transferase 1-1 by quinones and their glutathione conjugates : structure-activity relationship and mechanism by OMMEN, B. V, PLOEMEN, J. H. T. M, BOGAARDS, J. J. P, MONKS, T. J, GAU, S. S, BLADEREN, P. J. V

“…The irreversible inhibition of the rat glutathione S-transferase (GST) isoenzyme 1-1 by a series of halogenated 1,4-benzoquinones and their GSH conjugates was…”
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Toxicology of quinone-thioethers by Monks, T J, Lau, S S

“…Cytotoxicity associated with exposure to quinones has generally been attributed to either redox cycling, and the subsequent development of "oxidative stress,"…”
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Stimulation of N-methyl-D-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione by Leslie, S W, Brown, L M, Trent, R D, Lee, Y H, Morris, J L, Jones, T W, Randall, P K, Lau, S S, Monks, T J

“…The effects of GSH (gamma-glutamylcysteinylglycine) and GSSG on intracellular calcium levels ([Ca2+]i) were investigated using fura-2-loaded dissociated brain…”
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