Search Results - "Monk, Ian R"

Transforming the untransformable: application of direct transformation to manipulate genetically Staphylococcus aureus and Staphylococcus epidermidis by Monk, Ian R, Shah, Ishita M, Xu, Min, Tan, Man-Wah, Foster, Timothy J

“…The strong restriction barrier present in Staphylococcus aureus and Staphylococcus epidermidis has limited functional genomic analysis to a small subset of…”
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Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst by Tomlinson, Kira L., Riquelme, Sebastián A., Baskota, Swikrity Upadhyay, Drikic, Marija, Monk, Ian R., Stinear, Timothy P., Lewis, Ian A., Prince, Alice S.

“…Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even in the setting of a robust neutrophil…”
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Complete Bypass of Restriction Systems for Major Staphylococcus aureus Lineages by Monk, Ian R, Tree, Jai J, Howden, Benjamin P, Stinear, Timothy P, Foster, Timothy J

“…Staphylococcus aureus is a prominent global nosocomial and community-acquired bacterial pathogen. A strong restriction barrier presents a major hurdle for the…”
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Staphylococcal superantigens evoke temporary and reversible T cell anergy, but fail to block the development of a bacterium specific cellular immune response by Zhang, Heran, Monk, Ian R., Braverman, Jessica, Jones, Claerwen M., Brooks, Andrew G., Stinear, Timothy P., Wakim, Linda M.

“…Superantigens (sAgs) are bacterial virulence factors that induce a state of immune hyperactivation by forming a bridge between certain subsets of T cell…”
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RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3′UTR required for intermediate vancomycin resistance by Mediati, Daniel G., Wong, Julia L., Gao, Wei, McKellar, Stuart, Pang, Chi Nam Ignatius, Wu, Sylvania, Wu, Winton, Sy, Brandon, Monk, Ian R., Biazik, Joanna M., Wilkins, Marc R., Howden, Benjamin P., Stinear, Timothy P., Granneman, Sander, Tree, Jai J.

“…Treatment of methicillin-resistant Staphylococcus aureus infections is dependent on the efficacy of last-line antibiotics including vancomycin. Treatment…”
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Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment by Ge, Chenghao, Monk, Ian R., Pizzolla, Angela, Wang, Nancy, Bedford, James G., Stinear, Timothy P., Westall, Glen P., Wakim, Linda M.

“…Tissue-resident memory T (Trm) cells are described as having a “sensing and alarming” function, meaning they can rapidly release cytokines in response to local…”
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Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms by Geoghegan, Joan A, Monk, Ian R, O'Gara, James P, Foster, Timothy J

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis by Lee, Jean Y. H., Monk, Ian R., Gonçalves da Silva, Anders, Seemann, Torsten, Chua, Kyra Y. L., Kearns, Angela, Hill, Robert, Woodford, Neil, Bartels, Mette D., Strommenger, Birgit, Laurent, Frederic, Dodémont, Magali, Deplano, Ariane, Patel, Robin, Larsen, Anders R., Korman, Tony M., Stinear, Timothy P., Howden, Benjamin P.

“…Staphylococcus epidermidis is a conspicuous member of the human microbiome, widely present on healthy skin. Here we show that S. epidermidis has also evolved…”
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Polyclonal but not monoclonal circulating memory CD4 + T cells attenuate the severity of Staphylococcus aureus bacteremia by Braverman, Jessica, Monk, Ian R, Zhang, Heran, Stinear, Timothy P, Wakim, Linda M

“…bacteremia causes significant morbidity and mortality. Treatment of staphylococcal infections is hindered by widespread antibiotic resistance, and attempts to…”
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Tools for Functional Postgenomic Analysis of Listeria monocytogenes by Monk, Ian R, Gahan, Cormac G.M, Hill, Colin

“…We describe the development of genetic tools for regulated gene expression, the introduction of chromosomal mutations, and improved plasmid transfer by…”
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Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin by Mulcahy, Michelle E, Geoghegan, Joan A, Monk, Ian R, O'Keeffe, Kate M, Walsh, Evelyn J, Foster, Timothy J, McLoughlin, Rachel M

“…Staphylococcus aureus asymptomatically colonises the anterior nares, but the host and bacterial factors that facilitate colonisation remain incompletely…”
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Validation of a single-step, single-tube reverse transcription loop-mediated isothermal amplification assay for rapid detection of SARS-CoV-2 RNA by Lee, Jean Y H, Best, Nickala, McAuley, Julie, Porter, Jessica L, Seemann, Torsten, Schultz, Mark B, Sait, Michelle, Orlando, Nicole, Mercoulia, Karolina, Ballard, Susan A, Druce, Julian, Tran, Thomas, Catton, Mike G, Pryor, Melinda J, Cui, Huanhuan L, Luttick, Angela, McDonald, Sean, Greenhalgh, Arran, Kwong, Jason C, Sherry, Norelle L, Graham, Maryza, Hoang, Tuyet, Herisse, Marion, Pidot, Sacha J, Williamson, Deborah A, Howden, Benjamin P, Monk, Ian R, Stinear, Timothy P

“…The SARS-CoV-2 pandemic of 2020 has resulted in unparalleled requirements for RNA extraction kits and enzymes required for virus detection, leading to global…”
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Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus by Monk, Ian R., Shaikh, Nausad, Begg, Stephanie L., Gajdiss, Mike, Sharkey, Liam K. R., Lee, Jean Y. H., Pidot, Sacha J., Seemann, Torsten, Kuiper, Michael, Winnen, Brit, Hvorup, Rikki, Collins, Brett M., Bierbaum, Gabriele, Udagedara, Saumya R., Morey, Jacqueline R., Pulyani, Neha, Howden, Benjamin P., Maher, Megan J., McDevitt, Christopher A., King, Glenn F., Stinear, Timothy P.

“…WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus . WalKR regulates peptidoglycan synthesis, but this…”
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Within-host evolution of bovine Staphylococcus aureus selects for a SigB-deficient pathotype characterized by reduced virulence but enhanced proteolytic activity and biofilm formation by Marbach, Helene, Mayer, Katharina, Vogl, Claus, Lee, Jean Y. H., Monk, Ian R., Sordelli, Daniel O., Buzzola, Fernanda R., Ehling-Schulz, Monika, Grunert, Tom

“…Staphylococcus aureus is a major cause of bovine mastitis, commonly leading to long-lasting, persistent and recurrent infections. Thereby, S . aureus…”
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Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus by Pidot, Sacha J, Klatt, Stephan, Ates, Louis S, Frigui, Wafa, Sayes, Fadel, Majlessi, Laleh, Izumi, Hiroshi, Monk, Ian R, Porter, Jessica L, Bennett-Wood, Vicki, Seemann, Torsten, Otter, Ashley, Taiaroa, George, Cook, Gregory M, West, Nicholas, Tobias, Nicholas J, Fuerst, John A, Stutz, Michael D, Pellegrini, Marc, McConville, Malcolm, Brosch, Roland, Stinear, Timothy P

“…Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that…”
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Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus by Giulieri, Stefano G, Guérillot, Romain, Kwong, Jason C, Monk, Ian R, Hayes, Ashleigh S, Daniel, Diane, Baines, Sarah, Sherry, Norelle L, Holmes, Natasha E, Ward, Peter, Gao, Wei, Seemann, Torsten, Stinear, Timothy P, Howden, Benjamin P

“…Antistaphylococcal penicillins such as oxacillin are the key antibiotics in the treatment of invasive methicillin-susceptible (MSSA) infections; however,…”
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Publisher Correction: RNase III-CLASH of multi-drug resistant Staphylococcus aureus reveals a regulatory mRNA 3′UTR required for intermediate vancomycin resistance by Mediati, Daniel G., Wong, Julia L., Gao, Wei, McKellar, Stuart, Pang, Chi Nam Ignatius, Wu, Sylvania, Wu, Winton, Sy, Brandon, Monk, Ian R., Biazik, Joanna M., Wilkins, Marc R., Howden, Benjamin P., Stinear, Timothy P., Granneman, Sander, Tree, Jai J.

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Genetic manipulation of Staphylococci-breaking through the barrier by Monk, Ian R, Foster, Timothy J

“…Most strains of Staphylococcus aureus and Staphylococcus epidermidis possess a strong restriction barrier that hinders exchange of DNA. Recently, major…”
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Correspondence: Spontaneous secondary mutations confound analysis of the essential two-component system WalKR in Staphylococcus aureus by Monk, Ian R., Howden, Benjamin P., Seemann, Torsten, Stinear, Timothy P.

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Mining the Methylome Reveals Extensive Diversity in Staphylococcus epidermidis Restriction Modification by Lee, Jean Y H, Carter, Glen P, Pidot, Sacha J, Guérillot, Romain, Seemann, Torsten, Gonçalves da Silva, Anders, Foster, Timothy J, Howden, Benjamin P, Stinear, Timothy P, Monk, Ian R

“…is a significant opportunistic pathogen of humans. Molecular studies in this species have been hampered by the presence of restriction-modification (RM)…”
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