Search Results - "Moniz, Raymond"

A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties by Dooley, Kevin, McConnell, Russell E., Xu, Ke, Lewis, Nuruddeen D., Haupt, Sonya, Youniss, Madeleine R., Martin, Shelly, Sia, Chang Ling, McCoy, Christine, Moniz, Raymond J., Burenkova, Olga, Sanchez-Salazar, Jorge, Jang, Su Chul, Choi, Bryan, Harrison, Rane A., Houde, Damian, Burzyn, Dalia, Leng, Charan, Kirwin, Katherine, Ross, Nikki L., Finn, Jonathan D., Gaidukov, Leonid, Economides, Kyriakos D., Estes, Scott, Thornton, James E., Kulman, John D., Sathyanarayanan, Sriram, Williams, Douglas E.

“…Extracellular vesicles (EVs) are an important intercellular communication system facilitating the transfer of macromolecules between cells. Delivery of…”
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ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance by Jang, Su Chul, Economides, Kyriakos D., Moniz, Raymond J., Sia, Chang Ling, Lewis, Nuruddeen, McCoy, Christine, Zi, Tong, Zhang, Kelvin, Harrison, Rane A., Lim, Joanne, Dey, Joyoti, Grenley, Marc, Kirwin, Katherine, Ross, Nikki L., Bourdeau, Raymond, Villiger-Oberbek, Agata, Estes, Scott, Xu, Ke, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Williams, Douglas E., Sathyanarayanan, Sriram

“…Cyclic dinucleotide (CDN) agonists of the STimulator of InterferoN Genes (STING) pathway have shown immune activation and tumor clearance in pre-clinical…”
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Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo by Chang, De-Kuan, Moniz, Raymond J, Xu, Zhongyao, Sun, Jiusong, Signoretti, Sabina, Zhu, Quan, Marasco, Wayne A

“…Carbonic anhydrase (CA) IX is a surface-expressed protein that is upregulated by the hypoxia inducible factor (HIF) and represents a prototypic…”
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A vault nanoparticle vaccine induces protective mucosal immunity by Champion, Cheryl I, Kickhoefer, Valerie A, Liu, Guangchao, Moniz, Raymond J, Freed, Amanda S, Bergmann, Liisa L, Vaccari, Dana, Raval-Fernandes, Sujna, Chan, Ann M, Rome, Leonard H, Kelly, Kathleen A

“…Generation of robust cell-mediated immune responses at mucosal surfaces while reducing overall inflammation is a primary goal for vaccination. Here we report…”
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Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis by Kadić, Elma, Moniz, Raymond J, Huo, Ying, Chi, An, Kariv, Ilona

“…Comprehensive understanding of cellular immune subsets involved in regulation of tumor progression is central to the development of cancer immunotherapies…”
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Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determined by multiparametric single cell mass cytometry analysis by Kadić, Elma, Moniz, Raymond J., Huo, Ying, Chi, An, Kariv, Ilona

“…Background Comprehensive understanding of cellular immune subsets involved in regulation of tumor progression is central to the development of cancer…”
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Targeting Vault Nanoparticles to Specific Cell Surface Receptors by Kickhoefer, Valerie A, Han, Muri, Raval-Fernandes, Sujna, Poderycki, Michael J, Moniz, Raymond J, Vaccari, Dana, Silvestry, Mariena, Stewart, Phoebe L, Kelly, Kathleen A, Rome, Leonard H

“…As a naturally occurring nanocapsule abundantly expressed in nearly all-eukaryotic cells, the barrel-shaped vault particle is perhaps an ideal structure to…”
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793 Targeting engineered interleukin-2 (IL-2) to antigen specific T cells via novel biologic platforms by Moniz, Raymond, Vakkasoglu, Ahmet, Merazga, Zohra, Daigneault, Tina, Quayle, Steve, Girgis, Natasha, Seidel, Ronald, Ross, John, Low, Simon, Suri, Anish

“…BackgroundA key challenge with IL-2 immunotherapy for cancers is lack of selectivity for anti-tumor immune cells and safety liabilities related to…”
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720 CUE-102 selectively activates and expands WT1-specific T cells for the treatment of patients with WT1+ malignancies by Zhang, Christie, Girgis, Natasha, Merazga, Zohra, Hatfield, Steven, Histed, Alex, Zhao, Fan, Moniz, Raymond, Yeung, Kristin, Diaz, Fulvio, Brown, Jason, Haydock, Mark, Witt, Luke, Bautista, Wynona, Ross, John, Cemerski, Saso, Suri, Anish, Pienta, Kenneth, Levisetti, Matteo, Quayle, Steve

“…BackgroundWilms' Tumor 1 (WT1) was ranked as the highest priority antigen for therapeutic targeting in an effort by the National Cancer Institute. Development…”
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438 A phase 1 trial of CUE-101, a novel HPV16 E7-pHLA-IL2-Fc fusion protein, alone and in combination with pembrolizumab in patients with recurrent/metastatic HPV16+ head and neck cancer by Chung, Christine, Dimitrios Colevas, A, Gibson, Michael, Adkins, Douglas, Sukari, Ammar, Wirth, Lori, Burtness, Barbara, Bauman, Julie, Rodriguez, Cristina, Worden, Francis, Saba, Nabil, Glisson, Bonnie, Dunn, Lara, Seiwert, Tanguy, Agensky, Laura, Levisetti, Matteo, Lynam, Reena, Margossian, Steven, Moniz, Raymond, Quayle, Steve, Pienta, Kenneth, Pai, Sara

“…BackgroundImmuno-STATsTM are novel, modular fusion proteins designed to selectively activate tumor-antigen-specific CD8+ T cells. CUE-101 is comprised of a…”
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Identification of dendritic cell subsets responding to genital infection by Chlamydia muridarum by Moniz, Raymond J., Chan, Ann M., Kelly, Kathleen A.

“…Abstract Dendritic cells (DCs) are central for the induction of T-cell responses needed for chlamydial eradication. Here, we report the activation of two DC…”
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Plasmacytoid dendritic cells modulate nonprotective T-cell responses to genital infection by Chlamydia muridarum by Moniz, Raymond J, Chan, Ann M, Gordon, Lynn K, Braun, Jonathan, Arditi, Moshe, Kelly, Kathleen A

“…Given their immune-modulating capacity, regulatory T cells (Treg) cells may be important players in the induction of the protective T-cell response (Th1) to…”
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Integration of IL-2 signalling at the immunological synapse by Capera-Aragones, Jesusa, Chen, Lina, Suri, Anish, Moniz, Raymond, Dustin, Michael L.

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Understanding the spatial and functional link between the IL-2R and TCR at the immunological synapse by Capera-Aragones, Jesusa, Chen, Lina, Valvo, Salvatore, Suri, Anish, Moniz, Raymond, Dustin, Michael L.

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Blockade of epithelial membrane protein 2 (EMP2) abrogates infection of Chlamydia muridarum murine genital infection model by Shimazaki, Kaori, Chan, Ann M, Moniz, Raymond J, Wadehra, Madhuri, Nagy, Agnes, Coulam, Catherine P, Mareninov, Sergey, Lepin, Eric M, Wu, Anna M, Kelly, Kathleen A, Braun, Jonathan, Gordon, Lynn K

“…New methods are needed to eradicate or prevent Chlamydia trachomatis infections. Blockade of epithelial membrane protein 2 (EMP2) by genetic silencing or…”
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Phase 2 trial of three schedules of CUE-101 administered before surgery or chemoradiotherapy in HLA-A0201 positive patients with HPV16+ OPSCC by Zaretsky, Jesse Meir, Ley, Jessica C., Oppelt, Peter John, Mullins, Riley, Barrett, Thomas, Jackson, Ryan, Pipkorn, Patrik, Paniello, Randal C, Rich, Jason, Liu, Jingxia, Pennock, Sarah, Cohen, Jared, Thorstad, Wade, Quayle, Steven N, Moniz, Raymond, Goel, Apollina, Levisetti, Matteo, Suri, Anish, Puram, Sidharth, Adkins, Douglas

“…TPS6109 Background: Patients with locally advanced HPV+ OPSCC have a favorable prognosis; however, 10-40% will experience disease recurrence after…”
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Abstract LB-012: Single cell RNA-sequencing of multiple myeloma clinical patients for identifying novel immuno-oncology drug targets by Kumar, Namit, Peterson, Vanessa M., Zhang, Kelvin X., Li, Lixia, Garrett-Engele, Philip W., Moniz, Raymond J., Klappenbach, Joel A.

“…Recent advances in single cell genomic technologies have enabled unbiased quantification of cellular states within complex tissues, mechanisms of…”
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A phase 1 dose-escalation and expansion study of CUE-101, a novel HPV16 E7-pHLA-IL2-Fc fusion protein, given alone and in combination with pembrolizumab in patients with recurrent/metastatic HPV16+ head and neck cancer by Chung, Christine H., Colevas, A. Dimitrios, Adkins, Douglas, Gibson, Michael K., Rodriguez, Cristina P., Sukari, Ammar, Bauman, Julie E., Wirth, Lori J., Johnson, Faye M., Saba, Nabil F., Burtness, Barbara, Dunn, Lara, Seiwert, Tanguy Y., Worden, Francis P., Muzaffar, Jameel, Margossian, Steven, Moniz, Raymond, Quayle, Steven N, Levisetti, Matteo, Pai, Sara I.

“…6045 Background: Immuno-STATs are novel, modular fusion proteins designed to locally deliver cytokines for the selective activation of tumor-antigen specific…”
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Abstract 944: exoSTING: An engineered exosome therapeutic that selectively delivers STING agonist to the tumor resident antigen-presenting cells resulting in improved tumor antigen-specific adaptive immune response by Jang, Su Chul, Moniz, Raymond J., Sia, Chang Ling, Harrison, Rane A., Houde, Damian, Ross, Nikki, Xu, Ke, Lewis, Nuruddeen, Bourdeau, Raymond, McCoy, Christine, Zi, Tong, Villiger-Oberbek, Agata, Estes, Scott, Sanchez-Salazar, Jorge, Dooley, Kevin, Dahlberg, William K., Sathyanarayanan, Sriram, Economides, Kyriakos D.

“…Background: The Stimulator of Interferon Genes (STING) pathway is an attractive target in immuno-oncology. Selective activation of the STING pathway in antigen…”
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1323 CUE-102 selectively activates and expands WT1-specific T cells for the treatment of patients with WT1+ malignancies by Girgis, Natasha, Yu, Christie, Merazga, Zohra, Hatfield, Steven, Histed, Alex, Zhao, Fan, Moniz, Raymond, Yeung, Kristin, Diaz, Fulvio, Bautista, Wynona, Ross, John, Cemerski, Saso, Suri, Anish, Levisetti, Matteo, Quayle, Steven

“…BackgroundWilms’ Tumor 1 (WT1) was ranked as the highest priority antigen for therapeutic targeting in an effort by the National Cancer Institute. Development…”
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