Correlation between MRI (DWI and DCE) and cellularity of parotid gland pleomorphic adenomas

Purpose Parotid pleomorphic adenomas present a risk of recurrence, higher when the tumour is a hypocellular subtype. The aim of the study was to determine whether it is possible to characterize this histological subtype with diffusion and perfusion sequences of the preoperative MRI. Methods This ret...

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Bibliographic Details
Published in:	European archives of oto-rhino-laryngology Vol. 281; no. 5; pp. 2655 - 2665
Main Authors:	Monestier, Laura, Del Grande, Jean, Haddad, Ralph, Santini, Laure, Michel, Justin, Varoquaux, Arthur, Fakhry, Nicolas
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-05-2024
Subjects:	Head and Neck Head and Neck Surgery Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology Recurrence Histological subtype Parotid MRI Pleomorphic adenoma
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Summary:	Purpose Parotid pleomorphic adenomas present a risk of recurrence, higher when the tumour is a hypocellular subtype. The aim of the study was to determine whether it is possible to characterize this histological subtype with diffusion and perfusion sequences of the preoperative MRI. Methods This retrospective study included 97 patients operated between 2010 and 2020. Histologic slides review was performed to classify tumours into three histologic subtypes: hypocellular, classical and hypercellular. Univariate and multivariate analyses studied the correlation between histology and diffusion and perfusion MRI parameters obtained with OleaSphere® software. Results The hypocellular subtype had higher apparent diffusion coefficient values than the other two subtypes: 2.13 ± 0.23, 1.83 ± 0.42, and 1.61 ± 0.4 × 10 –3 mm 2 /s for hypocellular, classical and hypercellular subtype respectively ( p < 0.0001). Multivariate analysis showed that an ADC mean > 1.88 × 10 –3 mm 2 /s was suggestive of a hypocellular pleomorphic adenoma in 79% of the cases, with a specificity and PPV of 94 and 96% ( p < 0.001), respectively. Conclusion The histological subtype of a pleomorphic adenoma can be predicted preoperatively with ADC values. A prospective and multicentric study on a larger cohort is needed to confirm our results.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0937-4477 1434-4726
DOI:	10.1007/s00405-024-08562-8