Search Results - "Mondhe, D. M"
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Trilliumosides K and L, two novel steroidal saponins from rhizomes of Trillium govanianum , as potent anti-cancer agents targeting apoptosis in the A-549 cancer cell line
Published in Frontiers in chemistry (2023)“…Two novel steroidal saponins, trilliumosides K ( ) and L ( ), were isolated from the rhizomes of led by bioactivity-guided phytochemical investigation along…”
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Enhanced Anticancer Potential of Encapsulated Solid Lipid Nanoparticles of TPD: A Novel Triterpenediol from Boswellia serrata
Published in Molecular pharmaceutics (07-01-2013)“…A pentacyclic triterpenediol (TPD) from Boswellia serrata has significant cytotoxic and apoptotic potential in a large number of human cancer cell lines. To…”
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Chemically standardized isolates from Cedrus deodara stem wood having anticancer activity
Published in Planta medica (01-06-2007)“…An isolate "CD lignan mixture" comprising lignans from stem wood of Cedrus deodara consisted of (-)-wikstromal (75 - 79%), (-)-matairesinol (9 - 13%) and…”
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Antiproliferative efficacy of curcumin mimics through microtubule destabilization
Published in European journal of medicinal chemistry (10-05-2018)“…Curcumin possesses an attractive chemical structure with highly conjugated diferuloylmethane core. Curcumin mimics have been designed and prepared with an…”
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Antiproliferative activity of diarylnaphthylpyrrolidine derivative via dual target inhibition
Published in European journal of medicinal chemistry (15-02-2020)“…Breast cancer is the second leading cause of deaths in women globally. Present communication deals with design and synthesis of a few diarylnaphthyls as…”
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The augmented anticancer potential of AP9-cd loaded solid lipid nanoparticles in human leukemia Molt-4 cells and experimental tumor
Published in Chemico-biological interactions (25-01-2016)“…AP9-cd, a novel lignan composition from Cedrus deodara has significant anticancer potential, and to further enhance its activity, it was lucratively encumbered…”
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Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer
Published in Chemical biology & drug design (01-11-2016)“…Benzylidene indanones have been designed and synthesized from gallic acid, a plant phenolic acid as possible anticancer agent. The best analogue of the series,…”
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A novel microtubule depolymerizing colchicine analogue triggers apoptosis and autophagy in HCT-116 colon cancer cells
Published in Cell biochemistry and function (01-03-2016)“…Colchicine is a tubulin‐binding natural product isolated from Colchicum autumnale. Here we report the in vitro anticancer activity of C‐ring modified…”
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Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule
Published in European journal of pharmaceutical sciences (30-08-2015)“…[Display omitted] 3-(3′,4′,5′-Trimethoxyphenyl)-4,5,6-trimethoxy,2-(3″,4″-methylenedioxybenzylidene)-indan-1-one (1) is an optimized anti-cancer lead molecule…”
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Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin
Published in Cell death & disease (01-10-2014)“…Betulinic acid (BA) is a pentacyclic triterpenoid natural product reported to inhibit cell growth in a variety of cancers. However, the further clinical…”
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An improved synthesis of indanocine and antiproliferative activity of 2-benzyl-indanocine via microtubule destabilization
Published in Chemical biology & drug design (09-05-2021)“…Indanocine, a potent anticancer investigational drug of National Cancer Institute-USA has been much discussed in recent years. Present communication aimed at…”
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Reversal of Fibrogenic Events in Liver by Emblica officinalis (Fruit), an Indian Natural Drug
Published in Biological & Pharmaceutical Bulletin (01-07-2005)“…A hydroalcoholic (50%) extract of Emblica officinalis (fruit) (EO-50) reduced the severity of hepatic fibrosis induced by carbon tetrachloride (CCl4) and…”
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