Search Results - "Moncrieffe, Martin"

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling by Moncrieffe, Martin C., Bollschweiler, Daniel, Li, Bing, Penczek, Pawel A., Hopkins, Lee, Bryant, Clare E., Klenerman, David, Gay, Nicholas J.

“…Toll-like receptors (TLRs) are pivotal in triggering the innate immune response to pathogen infection. Ligand binding induces receptor dimerization which…”
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The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek's disease virus peptides by using an unprecedented binding motif by Halabi, Samer, Ghosh, Michael, Stevanović, Stefan, Rammensee, Hans-Georg, Bertzbach, Luca D, Kaufer, Benedikt B, Moncrieffe, Martin C, Kaspers, Bernd, Härtle, Sonja, Kaufman, Jim

“…Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health…”
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An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4 by Motshwene, Precious G., Moncrieffe, Martin C., Grossmann, J. Günter, Kao, Cheng, Ayaluru, Murali, Sandercock, Alan M., Robinson, Carol V., Latz, Eicke, Gay, Nicholas J.

“…Toll-like receptors (TLRs) mediate responses to pathogen-associated molecules as part of the vertebrate innate immune response to infection. Receptor…”
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Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome by Halabi, Samer, Sekine, Eiki, Verstak, Brett, Gay, Nicholas J., Moncrieffe, Martin C.

“…Ligand binding to Toll-like receptors (TLRs) results in dimerization of their cytosolic Toll/interleukin-1 receptor (TIR) domains and recruitment of…”
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Anterograde trafficking of Toll-like receptors requires the cargo sorting adaptors TMED-2 and 7 by Holm, Julia E J, Soares, Sandro G, Symmons, Martyn F, Huddin, Afiqah Saleh, Moncrieffe, Martin C, Gay, Nicholas J

“…Toll-Like Receptors (TLRs) play a pivotal role in immunity by recognising conserved structural features of pathogens and initiating the innate immune response…”
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Structure and dynamics of Toll immunoreceptor activation in the mosquito Aedes aegypti by Saucereau, Yoann, Wilson, Thomas H., Tang, Matthew C. K., Moncrieffe, Martin C., Hardwick, Steven W., Chirgadze, Dimitri Y., Soares, Sandro G., Marcaida, Maria Jose, Gay, Nicholas J., Gangloff, Monique

“…Aedes aegypti has evolved to become an efficient vector for arboviruses but the mechanisms of host-pathogen tolerance are unknown. Immunoreceptor Toll and its…”
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Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism by Gonzalez, Grecia M, Durica-Mitic, Svetlana, Hardwick, Steven W, Moncrieffe, Martin C, Resch, Marcus, Neumann, Piotr, Ficner, Ralf, Görke, Boris, Luisi, Ben F

“…In phylogenetically diverse bacteria, the conserved protein RapZ plays a central role in RNA-mediated regulation of amino-sugar metabolism. RapZ contributes to…”
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Negative Regulation of TLR Signaling by BCAP Requires Dimerization of Its DBB Domain by Lauenstein, Johannes U, Scherm, Michael J, Udgata, Atul, Moncrieffe, Martin C, Fisher, David I, Gay, Nicholas J

“…The B cell adaptor protein (BCAP) is a multimodular regulator of inflammatory signaling in diverse immune system cells. BCAP couples TLR signaling to…”
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The Human RNA Helicase DDX21 Presents a Dimerization Interface Necessary for Helicase Activity by Marcaida, Maria J., Kauzlaric, Annamaria, Duperrex, Alice, Sülzle, Jenny, Moncrieffe, Martin C., Adebajo, Damilola, Manley, Suliana, Trono, Didier, Dal Peraro, Matteo

“…Members of the DEAD-box helicase family are involved in all fundamental processes of RNA metabolism, and as such, their malfunction is associated with various…”
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Assembly of Oligomeric Death Domain Complexes during Toll Receptor Signaling by Moncrieffe, Martin C., Grossmann, J. Günter, Gay, Nicholas J.

“…The Drosophila Toll receptor is activated by the endogenous protein ligand Spätzle in response to microbial stimuli in immunity and spatial cues during…”
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The Crystal Structure of ZapA and its Modulation of FtsZ Polymerisation by Low, Harry H., Moncrieffe, Martin C., Löwe, Jan

“…FtsZ is part of a mid-cell cytokinetic structure termed the Z-ring that recruits a hierarchy of fission related proteins early in the bacterial cell cycle. The…”
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Structure of the Glycosyltransferase EryCIII in Complex with its Activating P450 Homologue EryCII by Moncrieffe, Martin C., Fernandez, Maria-Jose, Spiteller, Dieter, Matsumura, Hiroyoshi, Gay, Nicholas J., Luisi, Ben F., Leadlay, Peter F.

“…In the biosynthesis of the clinically important antibiotic erythromycin D, the glycosyltransferase (GT) EryCIII, in concert with its partner EryCII, attaches a…”
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Structure and regulation of cytoplasmic adapter proteins involved in innate immune signaling by Monie, Tom P, Moncrieffe, Martin C, Gay, Nicholas J

“…Initiation of the innate immune response requires agonist recognition by a pathogen recognition receptor. Following ligand binding, conformational…”
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Ligand-Receptor and Receptor-Receptor Interactions Act in Concert to Activate Signaling in the Drosophila Toll Pathway by Weber, Alexander N R, Moncrieffe, Martin C, Gangloff, Monique, Imler, Jean-Luc, Gay, Nicholas J

“…In Drosophila , the signaling pathway mediated by the Toll receptor is critical for the establishment of embryonic dorso-ventral pattern and for innate immune…”
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Role of the Spätzle Pro-domain in the Generation of an Active Toll Receptor Ligand by Weber, Alexander N.R., Gangloff, Monique, Moncrieffe, Martin C., Hyvert, Yann, Imler, Jean-Luc, Gay, Nicholas J.

“…The cytokine Spätzle is the ligand for Drosophila Toll, the prototype of an important family of membrane receptors that function in embryonic patterning and…”
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Quaternary Structure and Catalytic Activity of the Escherichia coli Ribonuclease E Amino-Terminal Catalytic Domain by Callaghan, Anastasia J., Grossmann, J. Günter, Redko, Yulia U., Ilag, Leopold L., Moncrieffe, Martin C., Symmons, Martyn F., Robinson, Carol V., McDowall, Kenneth J., Luisi, Ben F.

“…RNase E is an essential endoribonuclease that plays a central role in the processing and degradation of RNA in Escherichia coli and other bacteria. Most…”
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A Conserved α-Helical Motif Mediates the Interaction of Sp1-Like Transcriptional Repressors with the Corepressor mSin3A by Zhang, Jin-San, Moncrieffe, Martin C., Kaczynski, Joanna, Ellenrieder, Volker, Prendergast, Franklyn G., Urrutia, Raul

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Autonomous folding of interdomain regions of a modular polyketide synthase by Richter, Carsten D., Stanmore, David A., Miguel, Ricardo N., Moncrieffe, Martin C., Tran, Lucky, Brewerton, Suzanne, Meersman, Filip, Broadhurst, R. William, Weissman, Kira J.

“…Domains within the multienzyme polyketide synthases are linked by noncatalytic sequences of variable length and unknown function. Recently, the crystal…”
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Solution structure of the isolated Pelle death domain by Moncrieffe, Martin C., Stott, Katherine M., Gay, Nicholas J.

“…The interaction between the death domains (DDs) of Tube and the protein kinase Pelle is an important component of the Toll pathway. Published crystallographic…”
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Characterization of Symmetric Complexes of Nerve Growth Factor and the Ectodomain of the Pan-neurotrophin Receptor, p75NTR by Aurikko, Jukka P., Ruotolo, Brandon T., Grossmann, J. Günter, Moncrieffe, Martin C., Stephens, Elaine, Leppänen, Veli-Matti, Robinson, Carol V., Saarma, Mart, Bradshaw, Ralph A., Blundell, Tom L.

“…Nerve growth factor (NGF) is the ligand for two unrelated cellular receptors, TrkA and p75NTR, and acts as a mediator in the development and maintenance of the…”
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