Search Results - "Monchaud, David"

A Thermophilic Tetramolecular G‐Quadruplex/Hemin DNAzyme by Guo, Yuehua, Chen, Jielin, Cheng, Mingpan, Monchaud, David, Zhou, Jun, Ju, Huangxian

“…The quadruplex‐based DNAzyme system is one of the most useful artificial enzymes or catalysts; their unique properties make them reliable alternatives to…”
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Transcriptome-wide identification of transient RNA G-quadruplexes in human cells by Yang, Sunny Y., Lejault, Pauline, Chevrier, Sandy, Boidot, Romain, Robertson, A. Gordon, Wong, Judy M. Y., Monchaud, David

“…Guanine-rich RNA sequences can fold into four-stranded structures, termed G-quadruplexes (G4-RNAs), whose biological roles are poorly understood, and in vivo…”
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UV-induced G4 DNA structures recruit ZRF1 which prevents UV-induced senescence by De Magis, Alessio, Limmer, Michaela, Mudiyam, Venkat, Monchaud, David, Juranek, Stefan, Paeschke, Katrin

“…Senescence has two roles in oncology: it is known as a potent tumor-suppressive mechanism, which also supports tissue regeneration and repair, it is also known…”
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Visualization of RNA-Quadruplexes in Live Cells by Laguerre, Aurélien, Hukezalie, Kyle, Winckler, Pascale, Katranji, Fares, Chanteloup, Gaëtan, Pirrotta, Marc, Perrier-Cornet, Jean-Marie, Wong, Judy M. Y, Monchaud, David

“…Visualization of DNA and RNA quadruplex formation in human cells was demonstrated recently with different quadruplex-specific antibodies. Despite the…”
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A Twice-As-Smart Synthetic G‑Quartet: PyroTASQ Is Both a Smart Quadruplex Ligand and a Smart Fluorescent Probe by Laguerre, Aurélien, Stefan, Loic, Larrouy, Manuel, Genest, David, Novotna, Jana, Pirrotta, Marc, Monchaud, David

“…Recent and unambiguous evidences of the formation of DNA and RNA G-quadruplexes in cells has provided solid support for these structures to be considered as…”
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Caffeine-Based Gold(I) N‑Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties by Bertrand, Benoît, Stefan, Loic, Pirrotta, Marc, Monchaud, David, Bodio, Ewen, Richard, Philippe, Le Gendre, Pierre, Warmerdam, Elena, de Jager, Marina H, Groothuis, Geny M.M, Picquet, Michel, Casini, Angela

“…A new series of gold(I) N-heterocyclic carbene (NHC) complexes based on xanthine ligands have been synthesized and characterized by mass spectrometry, NMR, and…”
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How Proximal Nucleobases Regulate the Catalytic Activity of G‑Quadruplex/Hemin DNAzymes by Chen, Jielin, Zhang, Yingying, Cheng, Mingpan, Guo, Yuehua, Šponer, Jiri, Monchaud, David, Mergny, Jean-Louis, Ju, Huangxian, Zhou, Jun

“…G-quadruplexes (G4s) are versatile catalytic DNAs when combined with hemin. Despite the repertoire of catalytically competent G4/hemin complexes studied so…”
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Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons by Moruno-Manchon, Jose F, Lejault, Pauline, Wang, Yaoxuan, McCauley, Brenna, Honarpisheh, Pedram, Morales Scheihing, Diego A, Singh, Shivani, Dang, Weiwei, Kim, Nayun, Urayama, Akihiko, Zhu, Liang, Monchaud, David, McCullough, Louise D, Tsvetkov, Andrey S

“…Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures. G4-DNA regulates replication and transcription, at least in cancer…”
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Red Wine Extract Inhibits VEGF Secretion and Its Signaling Pathway in Retinal ARPE-19 Cells to Potentially Disrupt AMD by Cornebise, Clarisse, Courtaut, Flavie, Taillandier-Coindard, Marie, Valls-Fonayet, Josep, Richard, Tristan, Monchaud, David, Aires, Virginie, Delmas, Dominique

“…Age-related macular degeneration (AMD) is a degenerative disease of the retina where the molecular mechanism involves the production of vascular endothelial…”
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Development of a fluorescent intercalator displacement assay (G4-FID) for establishing quadruplex-DNA affinity and selectivity of putative ligands by Monchaud, David, Allain, Clémence, Teulade-Fichou, Marie-Paule

“…A fluorescent intercalator displacement assay (G4-FID) has been designed based on thiazole orange displacement from a quadruplex-forming oligonucleotide by…”
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Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action by De Cian, Anne, Cristofari, Gael, Reichenbach, Patrick, De Lemos, Elsa, Monchaud, David, Teulade-Fichou, Marie-Paule, Shin-ya, Kazuo, Lacroix, Laurent, Lingner, Joachim, Mergny, Jean-Louis

“…Quadruplex ligands are often considered as telomerase inhibitors. Given the fact that some of these molecules are present in the clinical setting, it is…”
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Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA by Yang, Peng, De Cian, Anne, Teulade-Fichou, Marie-Paule, Mergny, Jean-Louis, Monchaud, David

“…Lighting up: A G-quadruplex-specific fluorescent probe was designed combining the specificity of the pyridodicarboxamide motif for guanine quadruplexes and the…”
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Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity by Monchaud, David, Yang, Peng, Lacroix, Laurent, Teulade-Fichou, Marie-Paule, Mergny, Jean-Louis

“…Control by copper: CuII ions modulate the quadruplex affinity of the high‐affinity ligand 360A and denaturate the folded quadruplex form of DNA 22AG to an…”
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Side-by-side comparison of G-quadruplex (G4) capture efficiency of the antibody BG4 versus the small-molecule ligands TASQs by Feng, Yilong, He, Zexue, Luo, Zhenyu, Sperti, Francesco Rota, Valverde, Ibai E., Zhang, Wenli, Monchaud, David

“…The search for G-quadruplex (G4)-forming sequences across the genome is motivated by their involvement in key cellular processes and their putative roles in…”
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A Cost‐Effective Hemin‐Based Artificial Enzyme Allows for Practical Applications by Qiu, Dehui, He, Fangni, Liu, Yuan, Zhou, Zhaoxi, Yang, Yuqin, Long, Zhongwen, Chen, Qianqian, Chen, Desheng, Wei, Shijiong, Mao, Xuanxiang, Zhang, Xiaobo, Mergny, Jean‐Louis, Monchaud, David, Ju, Huangxian, Zhou, Jun

“…Nanomaterials excel in mimicking the structure and function of natural enzymes while being far more interesting in terms of structural stability, functional…”
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Assessing the Differential Affinity of Small Molecules for Noncanonical DNA Structures by Stefan, Loic, Bertrand, Benoît, Richard, Philippe, Le Gendre, Pierre, Denat, Franck, Picquet, Michel, Monchaud, David

“…The targeting of higher‐order DNA structures has been thoroughly developed with G‐quadruplex DNA but not with other structures like branched DNA (also known as…”
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Cationic azacryptands as selective three-way DNA junction binding agents by Novotna, Jana, Laguerre, Aurelien, Granzhan, Anton, Pirrotta, Marc, Teulade-Fichou, Marie-Paule, Monchaud, David

“…DNA damaging agents are among the most powerful anticancer drugs currently in clinical use. As an alternative to irreversible nucleobase damage and DNA strand…”
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Template-Assembled Synthetic G‑Quartets (TASQs): multiTASQing Molecular Tools for Investigating DNA and RNA G‑Quadruplex Biology by Monchaud, David

“…Conspectus Biomimetics is defined as a “practice of making technological design that copies natural processes”, with the idea that “nature has already solved…”
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Chrysin-Induced Regression of Angiogenesis via an Induction of DNA Damage Response and Oxidative Stress in In Vitro and In Vivo Models of Melanoma by Sassi, Aicha, Fredon, Maxime, Cotte, Alexia K, Fuselier, Camille, Schneider, Christophe, Martiny, Laurent, Monchaud, David, Chekir-Ghedira, Leila, Aires, Virginie, Delmas, Dominique

“…Despite the progress made in treatments, melanoma is one of the cancers for which its incidence and mortality have increased during recent decades. In the…”
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Why does the pUG tail curl? by Monchaud, David

“…Roschdi et al.1 report on a new, higher-order RNA structure folding from an alternating uridine (U)/guanosine (G) repeated sequence—the pUG tail—into a…”
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