Changes of Carotid Intima-Media Thickness After Sleeve Gastrectomy in High Cardiovascular Risk Patients: a Prospective Study

Changes of Carotid Intima-Media Thickness After Sleeve Gastrectomy in High Cardiovascular Risk Patients: a Prospective Study

Purpose There are insufficient data showing the impact of laparoscopic sleeve gastrectomy (LSG) on carotid intima-media thickness (CIMT). Therefore, in the current work, we investigated the improvement of metabolic syndrome and CIMT in patients with obesity after LSG. Methods This study involved 120...

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Bibliographic Details
Published in:Obesity surgery Vol. 31; no. 8; pp. 3541 - 3547
Main Authors: Salman, Mohamed Abdalla, Salman, Ahmed Abdallah, El Sherbiny, Mohammad, Elkholy, Shaimaa, Youssef, Ahmed, Labib, Safa, El-Din, Mohamed Tag, Monazea, Khaled A, Tourky, Mohamed Sabry, Mikhail, Hani Maurice Sabri, Maurice, Karim K, Abdallah, Ahmed, Mostafa, Mohamed Saber, Hussein, Ahmed Mahmoud, Abdelsalam, Ahmed Mohammed, Allah, Nesrin Abd, Ismaeel Saadawy, Amr M., Shaaban, Hossam El-Din, Sarhan, Mohamed D.
Format: Journal Article
Language:English
Published: New York Springer US 01-08-2021
Springer Nature B.V
Subjects:
Cardiovascular Diseases - etiology
Carotid Intima-Media Thickness
Egypt
Gastrectomy
Gastrointestinal surgery
Heart Disease Risk Factors
Humans
Laparoscopy
Medicine
Medicine & Public Health
Metabolism
Obesity, Morbid - surgery
Original Contributions
Prospective Studies
Risk Factors
Surgery
Weight control
Egypt
Metabolic syndrome
Laparoscopic sleeve gastrectomy
Bariatric surgery
Carotid intima-media thickness
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Summary:Purpose There are insufficient data showing the impact of laparoscopic sleeve gastrectomy (LSG) on carotid intima-media thickness (CIMT). Therefore, in the current work, we investigated the improvement of metabolic syndrome and CIMT in patients with obesity after LSG. Methods This study involved 120 consecutively selected Egyptian patients with a high cardiovascular risk who underwent LSG and were followed up for 12 months. Results CIMT declined from 0.95 ± 0.17 mm to 0.83 ± 0.12 ( p < 0.001) after 12 months. In addition, the mean fasting blood glucose and fasting inulin level dropped significantly from 153.3 ± 63.6 to 108.8 ± 33.8 mg/dl and from 23.1 ± 7.1 mU/ml to 14.1 ± 6.4 respectively ( p < 0.001). Furthermore, glycated hemoglobin (HbA1c) declined from 7.02 ± 1.7 to 5.5 ± 0.96 ( p < 0.001). At the end of the follow-up period, metabolic parameters such as HOMA-IR, C-reactive protein (CRP), fibrinogen, total cholesterol, LDL cholesterol, triglycerides, AST, and ALT decreased significantly from their respective baselines ( p value < 0.001). Moreover, the reduction in CIMT showed a strong positive correlation with the degree of weight loss at 6 months and 12 months of follow-up. Conclusion LSG led to a substantial decrease in CIMT. Moreover, it significantly impacted cardiovascular risk factors such as obesity, hypertension, insulin resistance, lipid profile, and inflammatory markers.
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ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-021-05419-5