Antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract of Laportea ovalifolia (Urticaceae), measured in rats with alloxan-induced diabetes

A decoction of the leaves of Laportea ovalifolia is widely used in Cameroon for the treatment of several illnesses, including diabetes mellitus. The antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract of the aerial parts of L. ovalifolia have now been investigated, in no...

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Bibliographic Details
Published in:	Annals of tropical medicine and parasitology Vol. 100; no. 1; pp. 69 - 74
Main Authors:	Momo, C. E. N., Oben, J. E., Tazoo, D., Dongo, E.
Format:	Journal Article
Language:	English
Published:	Leeds Taylor & Francis 01-01-2006 Maney Publishing
Subjects:	Animals Biological and medical sciences Blood Glucose - analysis Body Weight - drug effects Cholesterol - blood Cholesterol, HDL - blood Cholesterol, LDL - blood Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy Diabetes. Impaired glucose tolerance Drug Evaluation, Preclinical Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Hypoglycemic Agents - therapeutic use Hypolipidemic Agents - therapeutic use Male Medical sciences Methanol - therapeutic use Methylene Chloride - therapeutic use Plant Extracts - therapeutic use Rats Rats, Wistar Tolbutamide - therapeutic use Triglycerides - blood Urticaceae Endocrinopathy Rat Diabetes mellitus Rodentia Extract Biological activity Urticaceae Vertebrata Hypoglycemic agent Experimental disease Mammalia Dicotyledones Animal Angiospermae Plant origin Spermatophyta Antilipemic agent
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Summary:	A decoction of the leaves of Laportea ovalifolia is widely used in Cameroon for the treatment of several illnesses, including diabetes mellitus. The antidiabetic and hypolipidaemic effects of a methanol/methylene-chloride extract of the aerial parts of L. ovalifolia have now been investigated, in normal rats and rats with diabetes induced by the intraperitoneal injection of alloxan (at 150 mg/kg bodyweight). In the diabetic rats, 2 weeks of daily, intragastric treatment with the L. ovalifolia extract not only produced a significant reduction in the fasting serum glucose concentrations but also lowered the serum concentrations of total cholesterol, triglycerides, and low-density-lipoprotein cholesterol, lowered the ratio of total cholesterol to high-density-lipoprotein (HDL) cholesterol, and increased the serum concentration of HDL cholesterol. At least in rats with alloxan-induced diabetes, the methanol/methylene-chloride extract of L. ovalifolia therefore appears to possess antidiabetic and hypolipidaemic properties.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-4983 1364-8594
DOI:	10.1179/136485906X78517