Search Results - "Mom, C"

'DURVIT': a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment by Rotman, J, Mom, C H, Jordanova, E S, de Gruijl, T D, Kenter, G G

“…Treatment with programmed cell death receptor (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors is a promising strategy to lift tumour-induced…”
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Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients by Kenkhuis, Boyd, Somarakis, Antonios, de Haan, Lorraine, Dzyubachyk, Oleh, IJsselsteijn, Marieke E, de Miranda, Noel F C C, Lelieveldt, Boudewijn P F, Dijkstra, Jouke, van Roon-Mom, Willeke M C, Höllt, Thomas, van der Weerd, Louise

“…Brain iron accumulation has been found to accelerate disease progression in amyloid-β(Aβ) positive Alzheimer patients, though the mechanism is still unknown…”
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Efficacy of PD-1 blockade in cervical cancer is related to a CD8 + FoxP3 + CD25 + T-cell subset with operational effector functions despite high immune checkpoint levels by Heeren, A M, Rotman, J, Stam, A G M, Pocorni, N, Gassama, A A, Samuels, S, Bleeker, M C G, Mom, C H, Zijlmans, H J M A A, Kenter, G G, Jordanova, E S, de Gruijl, T D

“…Cervical cancer (CxCa) is mainly a locally invading disease that metastasizes to loco-regional lymph node basins before involving distant organs in more…”
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Does serous tubal intraepithelial carcinoma (STIC) metastasize? The clonal relationship between STIC and subsequent high-grade serous carcinoma in BRCA1/2 mutation carriers several years after risk-reducing salpingo-oophorectomy by van den Berg, C.B., Dasgupta, S., Ewing-Graham, P.C., Bart, J., Bulten, J., Gaarenstroom, K.N., de Hullu, J.A., Mom, C.H., Mourits, M.J.E., Steenbeek, M.P., van Marion, R., van Beekhuizen, H.J.

“…The majority of high-grade serous carcinomas (HGSC) of the ovary, fallopian tube, and peritoneum arise from the precursor lesion called serous tubal…”
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Post‐mortem 7T MR imaging and neuropathology in middle stage juvenile‐onset Huntington disease: A case report by Bakels, Hannah S., Duinen, Sjoerd G., Bresser, Jeroen, Roon‐Mom, Willeke M. C., Weerd, Louise, Bot, Susanne T.

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Clinical outcomes of pelvic exenteration for gynecologic malignancies by Moolenaar, L.R., van Rangelrooij, L.E., van Poelgeest, M.I.E., van Beurden, M., van Driel, W.J., van Lonkhuijzen, L.R.C.W., Mom, C.H., Zaal, A.

“…The aim of this study was to analyze morbidity and survival after pelvic exenteration for gynecologic malignancies and evaluate prognostic factors influencing…”
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A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours by Eskens, F A L M, Mom, C H, Planting, A S T, Gietema, J A, Amelsberg, A, Huisman, H, van Doorn, L, Burger, H, Stopfer, P, Verweij, J, de Vries, E G E

“…To assess tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and clinical activity of the dual epidermal growth factor receptor (EGFR) 1 and 2 (HER2)…”
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Peripheral mitochondrial function correlates with clinical severity in idiopathic Parkinson's disease by Milanese, Chiara, Payán‐Gómez, César, Galvani, Marta, Molano González, Nicolás, Tresini, Maria, Nait Abdellah, Soraya, van Roon‐Mom, Willeke M. C., Figini, Silvia, Marinus, Johan, van Hilten, Jacobus J., Mastroberardino, Pier G.

“…Background Parkinson's disease is an intractable disorder with heterogeneous clinical presentation that may reflect different underlying pathogenic mechanisms…”
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Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension by Curtis, Maurice A, Kam, Monica, Nannmark, Ulf, Anderson, Michelle F, Axell, Mathilda Zetterstrom, Wikkelso, Carsten, Holtås, Stig, van Roon-Mom, Willeke M.C, Björk-Eriksson, Thomas, Nordborg, Claes, Frisén, Jonas, Dragunow, Michael, Faull, Richard L.M, Eriksson, Peter S

“…The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS…”
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[ 18 F]FDG-PET/CT-based risk stratification in women with locally advanced uterine cervical cancer by Adam, J A, Poel, E, van Eck Smit, B L F, Mom, C H, Stalpers, L J A, Laan, J J, Kidd, E, Stoker, J, Bipat, S

“…[ F]FDG-PET/CT is used for staging and treatment planning in patients with locally advanced cervical cancer (LACC). We studied if a PET-based prediction model…”
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Transcriptional profiling and biomarker identification reveal tissue specific effects of expanded ataxin-3 in a spinocerebellar ataxia type 3 mouse model by Toonen, Lodewijk J A, Overzier, Maurice, Evers, Melvin M, Leon, Leticia G, van der Zeeuw, Sander A J, Mei, Hailiang, Kielbasa, Szymon M, Goeman, Jelle J, Hettne, Kristina M, Magnusson, Olafur Th, Poirel, Marion, Seyer, Alexandre, 't Hoen, Peter A C, van Roon-Mom, Willeke M C

“…Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by expansion of the polyglutamine repeat in the ataxin-3 protein…”
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Targeting several CAG expansion diseases by a single antisense oligonucleotide by Evers, Melvin M, Pepers, Barry A, van Deutekom, Judith C T, Mulders, Susan A M, den Dunnen, Johan T, Aartsma-Rus, Annemieke, van Ommen, Gert-Jan B, van Roon-Mom, Willeke M C

“…To date there are 9 known diseases caused by an expanded polyglutamine repeat, with the most prevalent being Huntington's disease. Huntington's disease is a…”
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Machine learning in Huntington's disease: exploring the Enroll-HD dataset for prognosis and driving capability prediction by Ouwerkerk, Jasper, Feleus, Stephanie, van der Zwaan, Kasper F, Li, Yunlei, Roos, Marco, van Roon-Mom, Willeke M C, de Bot, Susanne T, Wolstencroft, Katherine J, Mina, Eleni

“…In biomedicine, machine learning (ML) has proven beneficial for the prognosis and diagnosis of different diseases, including cancer and neurodegenerative…”
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Can serum human epididymis protein 4 (HE4) support the decision to refer a patient with an ovarian mass to an oncology hospital? by Lof, P., van de Vrie, R., Korse, C.M., van Gent, M.D.J.M., Mom, C.H., Rosier - van Dunné, F.M.F., van Baal, W.M., Verhoeve, H.R., Hermsen, B.B.J., Verbruggen, M.B., Hemelaar, M., van de Swaluw, A.M.G., Knipscheer, H.C., Huirne, J.A.F., Westenberg, S.M., van der Noort, V., Amant, F., van den Broek, D., Lok, C.A.R.

“…The value of serum human epididymis protein 4 (HE4) in guiding referral decisions in patients with an ovarian mass remains unclear, because the majority of…”
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Ataxin-3 Protein and RNA Toxicity in Spinocerebellar Ataxia Type 3: Current Insights and Emerging Therapeutic Strategies by Evers, Melvin M., Toonen, Lodewijk J. A., van Roon-Mom, Willeke M. C.

“…Ataxin-3 is a ubiquitously expressed deubiqutinating enzyme with important functions in the proteasomal protein degradation pathway and regulation of…”
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Calcium-Enhanced Medium-Based Delivery of Splice Modulating Antisense Oligonucleotides in 2D and 3D hiPSC-Derived Neuronal Models by Buijsen, Ronald A M, van der Graaf, Linda M, Kuijper, Elsa C, Pepers, Barry A, Daoutsali, Elena, Weel, Lotte, Raz, Vered, Parfitt, David A, van Roon-Mom, Willeke M C

“…Antisense technology demonstrates significant potential for addressing inherited brain diseases, with over a dozen products already available and numerous…”
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Mapping the glial transcriptome in Huntington's disease using snRNAseq: selective disruption of glial signatures across brain regions by Bøstrand, Sunniva M K, Seeker, Luise A, Bestard-Cuche, Nadine, Kazakou, Nina-Lydia, Jäkel, Sarah, Kenkhuis, Boyd, Henderson, Neil C, de Bot, Susanne T, van Roon-Mom, Willeke M C, Priller, Josef, Williams, Anna

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disease with a fatal outcome. There is accumulating evidence of a prominent role of glia…”
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Exploring the transcriptome of ciliated cells using in silico dissection of human tissues by Ivliev, Alexander E, 't Hoen, Peter A C, van Roon-Mom, Willeke M C, Peters, Dorien J M, Sergeeva, Marina G

“…Cilia are cell organelles that play important roles in cell motility, sensory and developmental functions and are involved in a range of human diseases, known…”
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TGFβ pathway deregulation and abnormal phospho‐SMAD2/3 staining in hereditary cerebral hemorrhage with amyloidosis‐Dutch type by Grand Moursel, Laure, Munting, Leon P., van der Graaf, Linda M., van Duinen, Sjoerd G., Goumans, Marie‐Jose T. H., Ueberham, Uwe, Natté, Remco, van Buchem, Mark A., van Roon‐Mom, Willeke M. C., van der Weerd, Louise

“…Hereditary cerebral hemorrhage with amyloidosis‐Dutch type (HCHWA‐D) is an early onset hereditary form of cerebral amyloid angiopathy (CAA) pathology, caused…”
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Therapeutic Strategies for Spinocerebellar Ataxia Type 1 by Kerkhof, Laurie M C, van de Warrenburg, Bart P C, van Roon-Mom, Willeke M C, Buijsen, Ronald A M

“…Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disorder that affects one or two individuals per 100,000. The disease is caused…”
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