Search Results - "Molyneux, Sam D."

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression by Harris, Isaac S., Treloar, Aislinn E., Inoue, Satoshi, Sasaki, Masato, Gorrini, Chiara, Lee, Kim Chung, Yung, Ka Yi, Brenner, Dirk, Knobbe-Thomsen, Christiane B., Cox, Maureen A., Elia, Andrew, Berger, Thorsten, Cescon, David W., Adeoye, Adewunmi, Brüstle, Anne, Molyneux, Sam D., Mason, Jacqueline M., Li, Wanda Y., Yamamoto, Kazuo, Wakeham, Andrew, Berman, Hal K., Khokha, Rama, Done, Susan J., Kavanagh, Terrance J., Lam, Ching-Wan, Mak, Tak W.

“…Controversy over the role of antioxidants in cancer has persisted for decades. Here, we demonstrate that synthesis of the antioxidant glutathione (GSH), driven…”
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Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis by Murthy, Aditya, Shao, Yang Washington, Narala, Swami R., Molyneux, Sam D., Zúñiga-Pflücker, Juan Carlos, Khokha, Rama

“…Epithelial cells of mucosal tissues provide a barrier against environmental stress, and keratinocytes are key decision makers for immune cell function in the…”
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Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state by Shimoda, Masayuki, Principe, Simona, Jackson, Hartland W., Luga, Valbona, Fang, Hui, Molyneux, Sam D., Shao, Yang W., Aiken, Alison, Waterhouse, Paul D., Karamboulas, Christina, Hess, Franz M., Ohtsuka, Takashi, Okada, Yasunori, Ailles, Laurie, Ludwig, Andreas, Wrana, Jeffrey L., Kislinger, Thomas, Khokha, Rama

“…Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of…”
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BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival by Gorrini, Chiara, Baniasadi, Pegah S, Harris, Isaac S, Silvester, Jennifer, Inoue, Satoshi, Snow, Bryan, Joshi, Purna A, Wakeham, Andrew, Molyneux, Sam D, Martin, Bernard, Bouwman, Peter, Cescon, David W, Elia, Andrew J, Winterton-Perks, Zoe, Cruickshank, Jennifer, Brenner, Dirk, Tseng, Alan, Musgrave, Melinda, Berman, Hal K, Khokha, Rama, Jonkers, Jos, Mak, Tak W, Gauthier, Mona L

“…Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress,…”
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A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis by Moriarity, Branden S, Otto, George M, Rahrmann, Eric P, Rathe, Susan K, Wolf, Natalie K, Weg, Madison T, Manlove, Luke A, LaRue, Rebecca S, Temiz, Nuri A, Molyneux, Sam D, Choi, Kwangmin, Holly, Kevin J, Sarver, Aaron L, Scott, Milcah C, Forster, Colleen L, Modiano, Jaime F, Khanna, Chand, Hewitt, Stephen M, Khokha, Rama, Yang, Yi, Gorlick, Richard, Dyer, Michael A, Largaespada, David A

“…Branden Moriarity, David Largaespada and colleagues report a Sleeping Beauty forward genetic screen in mice that identifies candidate genes and pathways for…”
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RANKL blockade prevents and treats aggressive osteosarcomas by Chen, Yan, Di Grappa, Marco A, Molyneux, Sam D, McKee, Trevor D, Waterhouse, Paul, Penninger, Josef M, Khokha, Rama

“…Osteosarcoma (OS) is the most common primary bone cancer, which occurs primarily in children and adolescents, severely affecting survivors' quality of life…”
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Author Correction: Human somatic cell mutagenesis creates genetically tractable sarcomas by Molyneux, Sam D., Waterhouse, Paul D., Shelton, Dawne, Shao, Yang W., Watling, Christopher M., Tang, Qing-Lian, Harris, Isaac S., Dickson, Brendan C., Tharmapalan, Pirashaanthy, Sandve, Geir K., Zhang, Xiaoyang, Bailey, Swneke D., Berman, Hal, Wunder, Jay S., Izsvák, Zsuzsanna, Lupien, Mathieu, Mak, Tak W., Khokha, Rama

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice by Molyneux, Sam D, Di Grappa, Marco A, Beristain, Alexander G, McKee, Trevor D, Wai, Daniel H, Paderova, Jana, Kashyap, Meenakshi, Hu, Pingzhao, Maiuri, Tamara, Narala, Swami R, Stambolic, Vuk, Squire, Jeremy, Penninger, Josef, Sanchez, Otto, Triche, Timothy J, Wood, Geoffrey A, Kirschner, Lawrence S, Khokha, Rama

“…Some cancers have been stratified into subclasses based on their unique involvement of specific signaling pathways. The mapping of human cancer genomes is…”
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Human somatic cell mutagenesis creates genetically tractable sarcomas by Molyneux, Sam D, Waterhouse, Paul D, Shelton, Dawne, Shao, Yang W, Watling, Christopher M, Tang, Qing-Lian, Harris, Isaac S, Dickson, Brendan C, Tharmapalan, Pirashaanthy, Sandve, Geir K, Zhang, Xiaoyang, Bailey, Swneke D, Berman, Hal, Wunder, Jay S, Izsvák, Zsuzsanna, Lupien, Mathieu, Mak, Tak W, Khokha, Rama

“…Rama Khokha and colleagues report a new mutagenesis method, called Lentihop, for creating spontaneous, genetically tractable tumors from normal human cells…”
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Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression by Harris, Isaac S., Treloar, Aislinn E., Inoue, Satoshi, Sasaki, Masato, Gorrini, Chiara, Lee, Kim Chung, Yung, Ka Yi, Brenner, Dirk, Knobbe-Thomsen, Christiane B., Cox, Maureen A., Elia, Andrew, Berger, Thorsten, Cescon, David W., Adeoye, Adewunmi, Brüstle, Anne, Molyneux, Sam D., Mason, Jacqueline M., Li, Wanda Y., Yamamoto, Kazuo, Wakeham, Andrew, Berman, Hal K., Khokha, Rama, Done, Susan J., Kavanagh, Terrance J., Lam, Ching-Wan, Mak, Tak W.

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Abstract 398: Genome-wide comparison of matched canine osteosarcoma primary tumours and metastases by array comparative genomic hybridization by Liu, Jonathan H W, Shao, Yang Washington, Molyneux, Sam D., Khokha, Rama, Wood, Geoffrey A.

“…Abstract Canine osteosarcoma is a common and highly aggressive cancer that shares many characteristics with human osteosarcoma and can serve as a model of this…”
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Erratum: Corrigendum: Human somatic cell mutagenesis creates genetically tractable sarcomas by Molyneux, Sam D, Waterhouse, Paul D, Shelton, Dawne, Shao, Yang W, Watling, Christopher M, Tang, Qing-Lian, Harris, Isaac S, Dickson, Brendan C, Tharmapalan, Pirashaanthy, Sandve, Geir K, Zhang, Xiaoyang, Bailey, Swneke D, Berman, Hal, Wunder, Jay S, Iszvak, Zsuzsanna, Lupien, Mathieu, Mak, Tak W, Khokha, Rama

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Correction: Corrigendum: Human somatic cell mutagenesis creates genetically tractable sarcomas by Molyneux, Sam D, Waterhouse, Paul D, Shelton, Dawne, Shao, Yang W, Watling, Christopher M, Tang, Qing-Lian, Harris, Isaac S, Dickson, Brendan C, Tharmapalan, Pirashaanthy, Sandve, Geir K, Zhang, Xiaoyang, Bailey, Swneke D, Berman, Hal, Wunder, Jay S, Iszvak, Zsuzsanna, Lupien, Mathieu, Mak, Tak W, Khokha, Rama

“…Nat. Genet. 46, 964–972 (2014); published online 17 August 2014; corrected after print 16 October 2014 In the version of this article initially published, the…”
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BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival by Gorrini, Chiara, Baniasadi, Pegah S., Harris, Isaac S., Silvester, Jennifer, Inoue, Satoshi, Snow, Bryan, Joshi, Purna A., Wakeham, Andrew, Molyneux, Sam D., Martin, Bernard, Bouwman, Peter, Cescon, David W., Elia, Andrew J., Winterton-Perks, Zoe, Cruickshank, Jennifer, Brenner, Dirk, Tseng, Alan, Musgrave, Melinda, Berman, Hal K., Khokha, Rama, Jonkers, Jos, Mak, Tak W., Gauthier, Mona L.

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Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice by Molyneux, Sam D, Grappa, Marco A. Di, Beristain, Alexander G, McKee, Trevor D, Wai, Daniel H, Paderova, Jana, Kashyap, Meenakshi, Hu, Pingzhao, Maiuri, Tamara, Narala, Swami R, Stambolic, Vuk, Squire, Jeremy, Penninger, Josef, Sanchez, Otto, Triche, Timothy J, Wood, Geoffrey A, Kirschner, Lawrence S, Khokha, Rama

“…Some cancers have been stratified into subclasses based on their unique involvement of specific signaling pathways. The mapping of human cancer genomes is…”
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