Search Results - "Molthoff, Carla F.M."

F8-IL10: A New Potential Antirheumatic Drug Evaluated by a PET-Guided Translational Approach by Bruijnen, Stefan T.G, Chandrupatla, Durga M.S.H, Giovanonni, Leonardo, Neri, Dario, Vugts, Danielle J, Huisman, Marc C, Hoekstra, Otto S, Musters, René J.P, Lammertsma, Adriaan A, van Dongen, Guus A.M.S, Jansen, Gerrit, Molthoff, Carla F.M, van der Laken, Conny J

“…Antibody fragment F8-mediated interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin…”
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VECTor: a preclinical imaging system for simultaneous submillimeter SPECT and PET by Goorden, Marlies C, van der Have, Frans, Kreuger, Rob, Ramakers, Ruud M, Vastenhouw, Brendan, Burbach, J Peter H, Booij, Jan, Molthoff, Carla F M, Beekman, Freek J

“…Today, PET and SPECT tracers cannot be imaged simultaneously at high resolutions but require 2 separate imaging systems. This paper introduces a Versatile…”
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Splicing modulation as novel therapeutic strategy against diffuse malignant peritoneal mesothelioma by Sciarrillo, Rocco, Wojtuszkiewicz, Anna, El Hassouni, Btissame, Funel, Niccola, Gandellini, Paolo, Lagerweij, Tonny, Buonamici, Silvia, Blijlevens, Maxime, Zeeuw van der Laan, Eveline A., Zaffaroni, Nadia, Deraco, Marcello, Kusamura, Shigeki, Würdinger, Tom, Peters, Godefridus J., Molthoff, Carla F.M., Jansen, Gerrit, Kaspers, Gertjan J.L., Cloos, Jacqueline, Giovannetti, Elisa

“…Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional chemotherapy. Despite improvements in survival…”
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Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation by Molthoff, Carla F. M., Jansen, Gerrit, Lammertsma, Adriaan Anthonius, de Greeuw, Inge, Gent, Yoony Y. J., Weijers, Karin, Chandrupatla, Durga M. S. H., van der Laken, Conny J.

“…To widen the therapeutic window for PET guided evaluation of novel anti-RA agents, modifications were made in a rat model of rheumatoid arthritis (RA)…”
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Evaluation of ( R)-[ 11C]verapamil as PET tracer of P-glycoprotein function in the blood–brain barrier: kinetics and metabolism in the rat by Luurtsema, Gert, Molthoff, Carla F.M., Schuit, Robert C., Windhorst, Albert D., Lammertsma, Adriaan A., Franssen, Eric J.F.

“…There is evidence that P-glycoprotein (P-gp) in the blood–brain barrier (BBB) may be involved in the aetiology of neurological disorders. For quantification of…”
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Peripheral metabolism of [18 F]FDDNP and cerebral uptake of its labelled metabolites by Luurtsema, Gert, Schuit, Robert C, Takkenkamp, Kevin, Lubberink, Mark, Hendrikse, N. Harry, Windhorst, Albert D, Molthoff, Carla F.M, Tolboom, Nelleke, van Berckel, Bart N.M, Lammertsma, Adriaan A

“…Abstract [18 F]FDDNP is a positron emission tomography (PET) tracer for determining amyloid plaques and neurofibrillary tangles in the brain in vivo. In order…”
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Clarifying the Diagnosis of Clinically Suspected Recurrence of Cervical Cancer: Impact of 18F-FDG PET by van der Veldt, Astrid A.M, Buist, Marrije R, van Baal, Marchien W, Comans, Emile F, Hoekstra, Otto S, Molthoff, Carla F.M

“…Clarifying the diagnosis of clinically suspected recurrence of cervical cancer can be challenging. The aim of this study was to investigate the clinical value…”
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18FDG uptake in esophageal cancer: linking biology and outcome by Westerterp, Marinke, Sloof, Gerrit W, Hoekstra, Otto S, ten Kate, Fiebo J.W, Meijer, Gerrit A, Reitsma, Johannes B, Boellaard, Ronald, Jan B. van Lanschot, J, Molthoff, Carla F.M

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The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis by Chandrupatla, Durga M. S. H., Molthoff, Carla F. M., Lammertsma, Adriaan A., van der Laken, Conny J., Jansen, Gerrit

“…Macrophages play a key role in the pathophysiology of rheumatoid arthritis (RA). Notably, positive correlations have been reported between synovial macrophage…”
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Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles by Turaihi, Alexander H, Serné, Erik H, Molthoff, Carla F M, Koning, Jasper J, Knol, Jaco, Niessen, Hans W, Goumans, Marie Jose T H, van Poelgeest, Erik M, Yudkin, John S, Smulders, Yvo M, Jimenez, Connie R, van Hinsbergh, Victor W M, Eringa, Etto C

“…Insulin-mediated microvascular recruitment (IMVR) regulates delivery of insulin and glucose to insulin-sensitive tissues. We have previously proposed that…”
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Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis by Steinz, Maarten M, Ezdoglian, Aiarpi, Khodadust, Fatemeh, Molthoff, Carla F M, Srinivasarao, Madduri, Low, Philip S, Zwezerijnen, Gerben J C, Yaqub, Maqsood, Beaino, Wissam, Windhorst, Albert D, Tas, Sander W, Jansen, Gerrit, van der Laken, Conny J

“…Non-invasive imaging modalities constitute an increasingly important tool in diagnostic and therapy response monitoring of patients with autoimmune diseases,…”
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A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells by de Bruin, Renée C. G., Veluchamy, John P., Lougheed, Sinéad M., Schneiders, Famke L., Lopez-Lastra, Silvia, Lameris, Roeland, Stam, Anita G., Sebestyen, Zsolt, Kuball, Jürgen, Molthoff, Carla F. M., Hooijberg, Erik, Roovers, Rob C., Santo, James P. Di, van Bergen en Henegouwen, Paul M. P., Verheul, Henk M. W., de Gruijl, Tanja D., van der Vliet, Hans J.

“…Though Vγ9Vδ2-T cells constitute only a small fraction of the total T cell population in human peripheral blood, they play a vital role in tumor defense and…”
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A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging by Keinänen, Outi, Li, Xiang-Guo, Chenna, Naveen K, Lumen, Dave, Ott, Jennifer, Molthoff, Carla F. M, Sarparanta, Mirkka, Helariutta, Kerttuli, Vuorinen, Tapani, Windhorst, Albert D, Airaksinen, Anu J

“…A new 18F-labeled tetrazine derivative was developed aiming at optimal radiochemistry, fast reaction kinetics in inverse electron-demand Diels–Alder…”
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High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model by Feroldi, Fabio, Verlaan, Mariska, Knaus, Helene, Davidoiu, Valentina, Vugts, Danielle J, van Dongen, Guus A M S, Molthoff, Carla F M, de Boer, Johannes F

“…With the emergence of immunotherapies for cancer treatment, there is a rising clinical need to visualize the tumor microenvironment (TME) non-invasively in…”
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A Multimodal Imaging Approach for Longitudinal Evaluation of Bladder Tumor Development in an Orthotopic Murine Model by Scheepbouwer, Chantal, Meyer, Sandra, Burggraaf, Maroeska J, Jose, Jithin, Molthoff, Carla F M

“…Bladder cancer is the fourth most common malignancy amongst men in Western industrialized countries with an initial response rate of 70% for the non-muscle…”
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Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis by Gent, Yoony Y J, Weijers, Karin, Molthoff, Carla F M, Windhorst, Albert D, Huisman, Marc C, Smith, Desirée E C, Kularatne, Sumith A, Jansen, Gerrit, Low, Philip S, Lammertsma, Adriaan A, van der Laken, Conny J

“…Detection of (subclinical) synovitis is relevant for both early diagnosis and monitoring of therapy of rheumatoid arthritis (RA). Previously, the potential of…”
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Cytolytic virus activation therapy and treatment monitoring for Epstein‐Barr virus associated nasopharyngeal carcinoma in a mouse tumor model by Novalić, Zlata, Verkuijlen, Sandra A. W. M., Verlaan, Mariska, Eersels, Jos L. H., de Greeuw, Inge, Molthoff, Carla F. M., Middeldorp, Jaap M., Greijer, Astrid E.

“…Undifferentiated nasopharyngeal carcinoma (NPC) is 100% associated with Epstein‐Barr virus (EBV). Expression of viral proteins in the tumor cells is highly…”
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In-vivo monitoring of anti-folate therapy in arthritic rats using [ 18 F]fluoro-PEG-folate and positron emission tomography by Chandrupatla, Durga M S H, Jansen, Gerrit, Vos, Ricardo, Verlaan, Mariska, Chen, Qingshou, Low, Philip S, Windhorst, Albert D, Lammertsma, Adriaan A, van der Laken, Conny J, Molthoff, Carla F M

“…Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is…”
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Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats: single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate by Chandrupatla, Durga M.S.H., Molthoff, Carla F.M., Ritsema, Wayne I.G.R., Vos, Ricardo, Elshof, Eline, Matsuyama, Takami, Low, Philip S., Musters, René J.P., Hammond, Anthony, Windhorst, Albert D., Lammertsma, Adriaan A., van der Laken, Conny J., Brands, Ruud, Jansen, Gerrit

“…Alkaline phosphatase (AP) is a gate-keeper of innate immune system responses by detoxifying inflammation triggering moieties released from endogenous and…”
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Biologic correlates of (18)fluorodeoxyglucose uptake in human breast cancer measured by positron emission tomography by Bos, Reinhard, van Der Hoeven, Jacobus J M, van Der Wall, Elsken, van Der Groep, Petra, van Diest, Paul J, Comans, Emile F I, Joshi, Urvi, Semenza, Gregg L, Hoekstra, Otto S, Lammertsma, Adriaan A, Molthoff, Carla F M

“…Variable uptake of the glucose analog (18)fluorodeoxyglucose (FDG) has been noticed in positron emission tomography (PET) studies of breast cancer patients,…”
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