Search Results - "Molowa, David T"

The state of biopharmaceutical manufacturing by Molowa, David T., Mazanet, Rosemary

“…The manufacturing of protein-based biopharmaceuticals is done in bacterial or mammalian cell cultures. While bacterial cultures are inexpensive, dependable,…”
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Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase by Winters, Charles J, Molowa, David T, Guzelian, Philip S

“…Chlordecone (Kepone), a toxic organochlorine pesticide, undergoes bioreduction to chlordecone alcohol in human liver. This reaction is controlled by a…”
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Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase by Wrighton, Steven A, Thomas, Paul E, Molowa, David T, Haniu, Mitsuru, Shively, John E, Maines, Sarah L, Watkins, Paul B, Parker, George, Mendez-Picon, Gerald

“…Through the use of monospecific antibodies directed against hepatic cytochrome P-450j, an enzyme induced in rats treated with ethanol or isoniazid, we have…”
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Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells by Sheares, Bradley T, White, Sylvia S, Molowa, David T, Chan, Karen, Ding, Victor D. H, Kroon, Paulus A, Bostedor, Richard G, Karkas, John D

“…A partial length cDNA encoding farnesyl pyrophosphate synthetase (hpt807) has been isolated from a human fetal liver cDNA library in lambda gt11. DNA sequence…”
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Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes by Schuetz, E G, Schuetz, J D, Strom, S C, Thompson, M T, Fisher, R A, Molowa, D T, Li, D, Guzelian, P S

“…The cytochrome P-450 3A gene family comprises the dominant forms of cytochrome P-450 found in human liver. We examined as a possible useful system for studying…”
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Transcriptional regulation of the human cholesterol 7.alpha.-hydroxylase gene by Molowa, David T, Chen, William S, Cimis, George M, Tan, Carina P

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Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3) by Wrighton, S A, Brian, W R, Sari, M A, Iwasaki, M, Guengerich, F P, Raucy, J L, Molowa, D T, Vandenbranden, M

“…The human P450III family has been shown to be composed of at least four members, P450IIIA3 (HLp), P450IIIA4 (P450NF), P450IIIA5 (HLp3), and P450IIIA6 (HLp2)…”
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Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene by Molowa, D T, Chen, W S, Cimis, G M, Tan, C P

“…As an initial step toward understanding the transcriptional regulation of cholesterol 7 alpha-hydroxylase (CYP7) in man, we isolated and functionally…”
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Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver by Schuetz, J D, Molowa, D T, Guzelian, P S

“…Adult human liver contains a form of cytochrome P450, termed HLp, that resembles the glucocorticoid-inducible cytochrome P450p in rat liver in its structure,…”
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Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P-450HLp in the adult by Wrighton, S A, Molowa, D T, Guzelian, P S

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Purification and characterization of aldo-keto reductases from gerbil liver: immunochemical evidence for related proteins in other mammalian species by Molowa, D T, Wrighton, S A, Guzelian, P S

“…We purified a hepatic aldehyde reductase (AR1) and two carbonyl reductases (CR1, CR2) from the Mongolian gerbil, an animal recently shown to closely resemble…”
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Characterization of a unique aldo-keto reductase responsible for the reduction of chlordecone in the liver of the gerbil and man by Molowa, D T, Wrighton, S A, Blanke, R V, Guzelian, P S

“…It has been established that the major metabolic pathway for chlordecone (CD) (Kepone) both in humans and in the Mongolian gerbil is bioreduction of this…”
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