Search Results - "Moloney, Harold"

Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction by Calvin, Joel R., Boyse, Raymond, Braden, Timothy M., Brewer, Alison C., Changi, Shujauddin, Harrold, Donal, Johnson, Martin, Kerr, Mark S., Lambertus, Gordon R., Luciani, Carla V., May, Scott A., Moloney, Harold, Murphy, John D., Roberts, Jeffrey C., Schafer, John P., Spencer, Richard D., Webster, Luke P.

“…A synthetic route to API was designed containing a Negishi cross-coupling reaction, where the zincate reagent was generated by transmetalation of a Grignard…”
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Cyclization of Methyl-Coumalate-Derived Methyl 1‑Benzamido-6-oxo-1,6-dihydropyridine-3-carboxylates: Assembly of the [1,2,4]Triazolo[1,5‑a]pyridine Ring System by Moloney, Harold, Magnus, Nicholas A, Buser, Jonas Y, Embry, Matthew C

“…An efficient three-step synthesis of a series of fused bicyclic s-[1,2,4]­triazolo­[1,5-a]­pyridines 1 was accomplished utilizing novel intermediates derived…”
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Development of an Improved Route for the Synthesis of an Abemaciclib Intermediate by Carroll, Michael P, Moloney, Harold, Gowran, Olivia, O’Connor, Aoibheann, Wilson, Eoin M, Murray, Michael M, Pietz, Mark A, Kjell, Douglas P, Held, C. Brad, Frederick, Michael O

“…A new synthesis for an intermediate of abemaciclib is described. Keys to this route are the use of inexpensive starting materials, biphasic amine alkylation…”
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