Search Results - "Moloney, Gerard M"

Revisiting Metchnikoff: Age-related Alterations in Microbiota-Gut-Brain Axis in the Mouse by Scott, Karen A, Ida, Masayuki, Peterson, Veronica L, Prenderville, Jack A, Moloney, Gerard M, Izumo, Takayuki, Murphy, Kiera, Murphy, Amy, Ross, R. Paul, Stanton, Catherine, Dinan, Timothy G, Cryan, John F

“…Highlights • The behaviour and physiology of young and aged mice were compared, with an emphasis on gut microbiota, gut permeability and markers of peripheral…”
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Microbial regulation of microRNA expression in the amygdala and prefrontal cortex by Hoban, Alan E, Stilling, Roman M, M Moloney, Gerard, Moloney, Rachel D, Shanahan, Fergus, Dinan, Timothy G, Cryan, John F, Clarke, Gerard

“…There is growing evidence for a role of the gut microbiome in shaping behaviour relevant to many psychiatric and neurological disorders. Preclinical studies…”
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Volatility as a Concept to Understand the Impact of Stress on the Microbiome by Bastiaanssen, Thomaz F.S, Gururajan, Anand, van de Wouw, Marcel, Moloney, Gerard M, Ritz, Nathaniel L, Long-Smith, Caitriona M, Wiley, Niamh C, Murphy, Amy B, Lyte, Joshua M, Fouhy, Fiona, Stanton, Catherine, Claesson, Marcus J, Dinan, Timothy G, Cryan, John F

“…•The gut microbiome is sensitive the effects of chronic stress.•We examined the stress-induced temporal effects on the composition of the microbiome, which we…”
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Maternal antibiotic administration during a critical developmental window has enduring neurobehavioural effects in offspring mice by O’Connor, Rory, Moloney, Gerard M., Fulling, Christine, O’Riordan, Kenneth J, Fitzgerald, Pat, Bastiaanssen, Thomaz F.S., Schellekens, Harriët, Dinan, Timothy G., Cryan, John F.

“…Rates of perinatal maternal antibiotic use have increased in recent years linked to prophylactic antibiotic use following Caesarean section delivery. This…”
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Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice by Stilling, Roman M, Moloney, Gerard M, Ryan, Feargal J, Hoban, Alan E, Bastiaanssen, Thomaz Fs, Shanahan, Fergus, Clarke, Gerard, Claesson, Marcus J, Dinan, Timothy G, Cryan, John F

“…Social behaviour is regulated by activity of host-associated microbiota across multiple species. However, the molecular mechanisms mediating this relationship…”
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Microbially-derived short-chain fatty acids impact astrocyte gene expression in a sex-specific manner by Spichak, Simon, Donoso, Francisco, Moloney, Gerard M., Gunnigle, Eoin, Brown, Jillian M., Codagnone, Martin, Dinan, Timothy G., Cryan, John F.

“…Recent investigations in neuroscience implicate the role of microbial-derived metabolites, such as short-chain fatty acids (SCFAs) in brain health and disease…”
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Improvements in sleep indices during exam stress due to consumption of a Bifidobacterium longum by Moloney, Gerard M., Long-Smith, Caitriona M., Murphy, Amy, Dorland, Danielle, Hojabri, Sara Firuzeh, Ramirez, Loreto Olavarría, Marin, David Campos, Bastiaanssen, Thomaz F.S., Cusack, Anne-Marie, Berding, Kirsten, Fouhy, Fiona, Allen, Andrew P., Stanton, Catherine, Clarke, Gerard, Dinan, Timothy G., Cryan, John F.

“…Targeting the gut microbiome as an effective therapeutic strategy for psychological disorders has shown promise in recent years. Variation in the composition…”
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Specific sub-regions along the longitudinal axis of the hippocampus mediate antidepressant-like behavioral effects by Levone, Brunno Rocha, Moloney, Gerard M., Cryan, John F., O'Leary, Olivia F.

“…Current antidepressants are suboptimal due incomplete understanding of the neurobiology underlying their behavioral effects. However, imaging studies suggest…”
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Prebiotic supplementation modulates selective effects of stress on behavior and brain metabolome in aged mice by Cruz-Pereira, Joana S., Moloney, Gerard M., Bastiaanssen, Thomaz F.S., Boscaini, Serena, Tofani, Gabriel, Borras-Bisa, Julia, van de Wouw, Marcel, Fitzgerald, Patrick, Dinan, Timothy G., Clarke, Gerard, Cryan, John F.

“…Aging has a significant impact on physiology with implications for central nervous system function coincident with increased vulnerability to stress exposures…”
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Altered stress responses in adults born by Caesarean section by Dinan, Timothy G., Kennedy, Paul J., Morais, Livia H., Murphy, Amy, Long-Smith, Caitriona M., Moloney, Gerard M., Bastiaanssen, Thomaz F.S., Allen, Andrew P., Collery, Aoife, Mullins, David, Cusack, Anne-Marie, Berding, Kirsten, O'Toole, Paul W., Clarke, Gerard, Stanton, Catherine, Cryan, John F.

“…Birth by Caesarean-section (C-section), which increases the risk for metabolic and immune disorders, disrupts the normal initial microbial colonisation of the…”
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Short chain fatty acids: Microbial metabolites for gut-brain axis signalling by O'Riordan, Kenneth J., Collins, Michael K., Moloney, Gerard M., Knox, Emily G., Aburto, María R., Fülling, Christine, Morley, Shane J., Clarke, Gerard, Schellekens, Harriët, Cryan, John F.

“…The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to prominence in recent years. Understanding the relationship…”
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Feed your microbes to deal with stress: a psychobiotic diet impacts microbial stability and perceived stress in a healthy adult population by Berding, Kirsten, Bastiaanssen, Thomaz F. S., Moloney, Gerard M., Boscaini, Serena, Strain, Conall R., Anesi, Andrea, Long-Smith, Caitriona, Mattivi, Fulvio, Stanton, Catherine, Clarke, Gerard, Dinan, Timothy G., Cryan, John F.

“…The impact of diet on the microbiota composition and the role of diet in supporting optimal mental health have received much attention in the last decade…”
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Omega-3 polyunsaturated fatty acids critically regulate behaviour and gut microbiota development in adolescence and adulthood by Robertson, Ruairi C, Oriach, Clara Seira, Murphy, Kiera, Moloney, Gerard M, Cryan, John F, Dinan, Timothy G, Paul Ross, R, Stanton, Catherine

“…Highlights • Maternal and lifelong omega-3 deficiency impairs early-life communicative behaviour, adult social behaviour and augments adult depression-like…”
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The immune-kynurenine pathway in social anxiety disorder by Butler, Mary I., Long-Smith, Caitriona, Moloney, Gerard M., Morkl, Sabrina, O'Mahony, Siobhain M., Cryan, John F., Clarke, Gerard, Dinan, Timothy G.

“…•The tryptophan-kynurenine pathway is of growing interest in neuropsychiatric disorders but has never been investigated in social anxiety disorder (SAD)…”
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Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome by Boehme, Marcus, van de Wouw, Marcel, Bastiaanssen, Thomaz F. S., Olavarría-Ramírez, Loreto, Lyons, Katriona, Fouhy, Fiona, Golubeva, Anna V., Moloney, Gerard M., Minuto, Chiara, Sandhu, Kiran V., Scott, Karen A., Clarke, Gerard, Stanton, Catherine, Dinan, Timothy G., Schellekens, Harriët, Cryan, John F.

“…Male middle age is a transitional period where many physiological and psychological changes occur leading to cognitive and behavioural alterations, and a…”
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Microbial regulation of microRNA expression in the brain–gut axis by Moloney, Gerard M, Dinan, Timothy G, Clarke, Gerard, Cryan, John F

“…The gut microbiome facilitates a consistent transfer of information between the gut and the brain and microRNAs may now represent a key signalling molecule…”
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Adherence to a psychobiotic diet stabilizes the microbiome and reduces perceived stress: plenty of food for thought by Berding, Kirsten, Bastiaanssen, Thomaz F S, Moloney, Gerard M, Clarke, Gerard, Dinan, Timothy G, Cryan, John F

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Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse by Morais, Livia H., Golubeva, Anna V., Moloney, Gerard M., Moya-Pérez, Angela, Ventura-Silva, Ana Paula, Arboleya, Silvia, Bastiaanssen, Thomaz F.S., O’Sullivan, Orla, Rea, Kieran, Borre, Yuliya, Scott, Karen A., Patterson, Elaine, Cherry, Paul, Stilling, Roman, Hoban, Alan E., El Aidy, Sahar, Sequeira, Ana M., Beers, Sasja, Moloney, Rachel D., Renes, Ingrid B., Wang, Shugui, Knol, Jan, Ross, R. Paul, O’Toole, Paul W., Cotter, Paul D., Stanton, Catherine, Dinan, Timothy G., Cryan, John F.

“…Birth by Caesarean (C)-section impacts early gut microbiota colonization and is associated with an increased risk of developing immune and metabolic disorders…”
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Microbial regulation of hippocampal miRNA expression: Implications for transcription of kynurenine pathway enzymes by Moloney, Gerard M., O’Leary, Olivia F., Salvo-Romero, Eloisa, Desbonnet, Lieve, Shanahan, Fergus, Dinan, Timothy G., Clarke, Gerard, Cryan, John F.

“…•The gut microbiota influences gene expression in the hippocampus.•This influence may be linked with tryptophan metabolism.•Transcriptional changes are…”
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Age-associated deficits in social behaviour are microbiota-dependent by Cruz-Pereira, Joana S., Moloney, Gerard M., Bastiaanssen, Thomaz F.S., Boscaini, Serena, Fitzgerald, Patrick, Clarke, Gerard, Cryan, John F.

“…•Gut microbial depletion can reverse age-dependent social behavior deficits.•Age-associated accumulation of CD4 + T cells in the brain ventricles can be…”
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