Search Results - "Molnár, Joseph"

Diterpenes from European Euphorbia Species Serving as Prototypes for Natural-Product-Based Drug Discovery by Vasas, Andrea, Rédei, Dóra, Csupor, Dezső, Molnár, Joseph, Hohmann, Judit

“…Diterpenes occurring in plants of the Euphorbiaceae family are of considerable interest in the context of natural product drug discovery programs because of…”
Get full text

Dually Acting Nonclassical 1,4-Dihydropyridines Promote the Anti-Tuberculosis (Tb) Activities of Clofazimine by Lentz, Fabian, Reiling, Norbert, Spengler, Gabriella, Kincses, Annamária, Csonka, Andrea, Molnár, Joseph, Hilgeroth, Andreas

“…The number of effective antituberculotic drugs is strongly limited to four first-line drugs in standard therapy. In case of resistances second-line antibiotics…”
Get full text

Organosilicon Compounds, SILA-409 and SILA-421, as Doxorubicin Resistance-Reversing Agents in Human Colon Cancer Cells by Wesołowska, Olga, Michalak, Krystyna, Błaszczyk, Maria, Molnár, Joseph, Środa-Pomianek, Kamila

“…Multidrug resistance (MDR) that occurs in cancer cells constitutes one of the major reasons for chemotherapy failure. The main molecular mechanism of MDR is…”
Get full text

Backstabbing P-gp: Side-Chain Cleaved Ecdysteroid 2,3-Dioxolanes Hyper-Sensitize MDR Cancer Cells to Doxorubicin without Efflux Inhibition by Hunyadi, Attila, Csábi, József, Martins, Ana, Molnár, Joseph, Balázs, Attila, Tóth, Gábor

“…P-glycoprotein (P-gp, ABCB1) over-expression, causing a multi-drug resistant (MDR) phenotype, is a major problem in cancer chemotherapy that urgently requires…”
Get full text

Discovery of Novel Enhancers of Isoniazid Toxicity in Mycobacterium tuberculosis by Lentz, Fabian, Reiling, Norbert, Martins, Ana, Molnár, Joseph, Hilgeroth, Andreas

“…The number of effective first-line antibiotics for the treatment of infection is strongly limited to a few drugs. Due to emerging resistance against those…”
Get full text

Benzoxazole-based Zn(II) and Cu(II) Complexes Overcome Multidrug-resistance in Cancer by Spengler, Gabriella, Kincses, Annamária, Rácz, Bálint, Varga, Borisz, Watanabe, Genki, Saijo, Ryosuke, Sekiya, Hiroshi, Tamai, Eiji, Maki, Jun, Molnár, Joseph, Kawase, Masami

“…Multidrug resistance (MDR) represents a significant impediment to successful cancer treatment. In this study, novel metal [Zn(II), Cu(II), Mg(II), Ni(II),…”
Get full text

Benzoxazole-Based Metal Complexes to Reverse Multidrug Resistance in Bacteria by Kincses, Annamária, Szabó, Stefánia, Rácz, Bálint, Szemerédi, Nikoletta, Watanabe, Genki, Saijo, Ryosuke, Sekiya, Hiroshi, Tamai, Eiji, Molnár, Joseph, Kawase, Masami, Spengler, Gabriella

“…Bacteria often show resistance against antibiotics due to various mechanisms such as the expression of efflux pumps, biofilm formation, or bacterial quorum…”
Get full text

Anticancer and multidrug resistance-reversal effects of solanidine analogs synthetized from pregnadienolone acetate by Zupkó, István, Molnár, Judit, Réthy, Borbála, Minorics, Renáta, Frank, Eva, Wölfling, János, Molnár, Joseph, Ocsovszki, Imre, Topcu, Zeki, Bitó, Tamás, Puskás, László G

“…A set of solanidine analogs with antiproliferative properties were recently synthetized from pregnadienolone acetate, which occurs in Nature. The aim of the…”
Get full text

3,5-Dibenzoyl-1,4-dihydropyridines: Synthesis and MDR Reversal in Tumor Cells by Kawase, Masami, Shah, Anamik, Gaveriya, Harsukh, Motohashi, Noboru, Sakagami, Hiroshi, Varga, Andreas, Molnár, Joseph

“…Fifteen 4-phenyl-3,5-dibenzoyl-1,4-dihydropyridines (BzDHPs) (1–15) substituted at the 4-phenyl ring were synthesized and compared to their cytotoxic activity…”
Get full text

Discovery and Biological Evaluation of a New Family of Potent Modulators of Multidrug Resistance:  Reversal of Multidrug Resistance of Mouse Lymphoma Cells by New Natural Jatrophane Diterpenoids Isolated from Euphorbia Species by Hohmann, Judit, Molnár, Joseph, Rédei, Dóra, Evanics, Ferenc, Forgo, Peter, Kálmán, Alajos, Argay, Gyula, Szabó, Pál

“…The effects of 15 jatrophane diterpene polyesters (1 − 3 and 5 − 16) isolated from lipophilic extracts of Euphorbia serrulata, E. esula, E. salicifolia, and E…”
Get full text

Possible Biological and Clinical Applications of Phenothiazines by Varga, Borisz, Csonka, Ákos, Csonka, Andrea, Molnár, Joseph, Amaral, Leonard, Spengler, Gabriella

“…Phenothiazines have been used in many areas of medicine, mainly in psychopharmacology. These compounds are able to effectively inhibit dopamine, histamine,…”
Get full text

Vitamin A and Wound Healing by Zinder, Roman, Cooley, Rachel, Vlad, Lucian G., Molnar, Joseph A.

“…Vitamin A is a general term for retinoids. Vitamin A deficiency leads to a variety of cutaneous manifestations. It also functions as a hormone through retinoic…”
Get full text

Effects of mycotoxins on human immune functions in vitro by Berek, L., Petri, I.B., Mesterházy, Á., Téren, Joseph, Molnár, Joseph

“…Immunosuppressive and carcinogenic Fusarium mycotoxins may appear in domestic food products. Therefore, the immunological effects of Fusarium mycotoxins were…”
Get full text

Estimating density, velocity, and pressure fields in supersonic flows using physics-informed BOS by Molnar, Joseph P., Venkatakrishnan, Lakshmi, Schmidt, Bryan E., Sipkens, Timothy A., Grauer, Samuel J.

“…We report a new workflow for background-oriented schlieren (BOS), termed “physics-informed BOS,” to extract density, velocity, and pressure fields from a pair…”
Get full text

Biological activity of persimmon (Diospyros kaki) peel extracts by Kawase, Masami, Motohashi, Noboru, Satoh, Kazue, Sakagami, Hiroshi, Nakashima, Hideki, Tani, Satoru, Shirataki, Yoshiaki, Kurihara, Teruo, Spengler, Gabriella, Wolfard, Krisztina, Molnár, Joseph

“…Fractionated extracts of persimmon (Diospyros kaki) peels were studied for cytotoxic activity, multidrug resistance (MDR) reversal activity, anti‐human…”
Get full text

New macrocyclic lathyrane diterpenes, from Euphorbia lagascae, as inhibitors of multidrug resistance of tumour cells by Duarte, Noélia, Gyémánt, Nora, Abreu, Pedro M, Molnár, Joseph, Ferreira, Maria-José U

“…The new macrocyclic lathyrane diterpenes latilagascenes A and B ( 1 and 2), the diacetylated derivative of 2, latilagascene C ( 3), and the known diterpenes…”
Get more information

GRP78 upregulation-induced increase in cisplatin sensitivity of SPCA1 lung cancer cells by Zhang, Li-Chuan, Wang, Jia-Rui, Zhao, Long, Wang, Tao, Wu, Jing, Fan, Su-Fang, Chen, Li-Xia, Shao, Shu-Juan, Molnár, Joseph, Wang, Qi

“…Background Glucose regulated protein 78 （GRP78）, an endoplasmic reticulum （ER） chaperone, plays a critical role in chemotherapy resistance in a variety of…”
Get full text

The Anticancer Activity of the Old Neuroleptic Phenothiazine-type Drug Thioridazine by Spengler, Gabriella, Csonka, Ákos, Molnár, Joseph, Amaral, Leonard

“…Thioridazine (TZ), an antipsychotic drug, renders multidrug-resistant (MDR) cancer cells susceptible to cytotoxic agents to which they were initially…”
Get full text

Biological activity of carotenoids in red paprika, Valencia orange and Golden delicious apple by Molnar, P, Kawase, M, Satoh, K, Sohara, Y, Tanaka, T, Tani, S, Sakagami, H, Nakashima, H, Motohashi, N, Gyemant, N

“…Carotenoid fractions were extracted from red paprika, Valencia orange peel and the peel of Golden delicious apple. Thus, hypophasic carotenoids of paprika…”
Get full text

A global plan for burn prevention and care by Peck, Michael, Molnar, Joseph, Swart, Dehran

Get full text