Search Results - "Mollink, Jeroen"
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Evaluating fibre orientation dispersion in white matter: Comparison of diffusion MRI, histology and polarized light imaging
Published in NeuroImage (Orlando, Fla.) (15-08-2017)“…Diffusion MRI is an exquisitely sensitive probe of tissue microstructure, and is currently the only non-invasive measure of the brain's fibre architecture. As…”
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The spatial correspondence and genetic influence of interhemispheric connectivity with white matter microstructure
Published in Nature neuroscience (01-05-2019)“…Microscopic features (that is, microstructure) of axons affect neural circuit activity through characteristics such as conduction speed. To what extent axonal…”
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3
Methods for quantitative susceptibility and R2 mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis
Published in NeuroImage (Orlando, Fla.) (15-11-2020)“…Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local concentration of iron and myelin. Here, we describe a robust image…”
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Decoding the microstructural properties of white matter using realistic models
Published in NeuroImage (Orlando, Fla.) (15-08-2021)“…•A pipeline to generate realistic white models of arbitrary fiber volume fraction and g-ratio is presented.•We present a methodology to simulated the gradient…”
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Estimating axial diffusivity in the NODDI model
Published in NeuroImage (Orlando, Fla.) (15-11-2022)“…•Demonstrate how NODDI outputs change when the assumed axial diffusivity is modified.•Combine high b-value data (to isolate intra-axonal signal) with dispersed…”
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6
An open resource combining multi-contrast MRI and microscopy in the macaque brain
Published in Nature communications (19-07-2023)“…Understanding brain structure and function often requires combining data across different modalities and scales to link microscale cellular structures to…”
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An automated pipeline for extracting histological stain area fraction for voxelwise quantitative MRI-histology comparisons
Published in NeuroImage (Orlando, Fla.) (01-12-2022)“…•Automated pipeline to generate quantitative maps from immunohistochemical stains.•Pipeline is generalisable to stains targeting multiple…”
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Tensor image registration library: Deformable registration of stand‐alone histology images to whole‐brain post‐mortem MRI data
Published in NeuroImage (Orlando, Fla.) (01-01-2023)“…•New software framework for prototyping bespoke image registration pipelines.•Configurable pipeline to register stand-alone histology sections to whole-brain…”
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The Digital Brain Bank, an open access platform for post-mortem imaging datasets
Published in eLife (17-03-2022)“…Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins…”
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Post-mortem 11.7 Tesla Magnetic Resonance Imaging vs. Polarized Light Imaging Microscopy to Measure the Angle and Orientation of Dorsal Root Afferents in the Human Cervical Dorsal Root Entry Zone
Published in Frontiers in neuroanatomy (02-07-2019)“…: Destruction of the afferents by dorsal root entry zone (DREZ) surgery may be an effective treatment of intractable neuropathic pain, though it remains a…”
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Joint modelling of diffusion MRI and microscopy
Published in NeuroImage (Orlando, Fla.) (01-11-2019)“…The combination of diffusion MRI (dMRI) with microscopy provides unique opportunities to study microstructural features of tissue, particularly when acquired…”
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Imaging white matter microstructure with gradient-echo phase imaging: Is ex vivo imaging with formalin-fixed tissue a good approximation of the in vivo brain?
Published in Magnetic resonance in medicine (01-07-2022)“…Ex vivo imaging is a commonly used approach to investigate the biophysical mechanism of orientation-dependent signal phase evolution in white matter. Yet, how…”
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Abstract PD6-02: Digital MammaPrint and BluePrint using machine learning and whole slide imaging
Published in Cancer research (Chicago, Ill.) (15-02-2021)“…Abstract Background: The rise of whole slide imaging systems has enabled pathologists to remotely view cases in high resolution to diagnose cancer, and…”
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14
The spatial correspondence and genetic influence of inter-hemispheric connectivity with white matter microstructure
Published in Nature neuroscience (15-04-2019)“…Microscopic features (i.e., microstructure) of axons affect neural circuit activity through characteristics such as conduction speed. To what extent axonal…”
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15
Ex vivo visualization of the trigeminal pathways in the human brainstem using 11.7T diffusion MRI combined with microscopy polarized light imaging
Published in Brain Structure and Function (01-01-2019)“…Classic anatomical atlases depict a contralateral hemispheral representation of each side of the face. Recently, however, a bilateral projection of each…”
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Mapping the trigeminal root entry zone and its pontine fibre distribution patterns
Published in Cephalalgia (01-12-2020)“…Recently, an additional trigeminothalamic tract - the dorsal trigeminothalamic tract - has been described in human brainstems by our group next to the known…”
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17
Choice of reference measurements affects quantification of long diffusion time behaviour using stimulated echoes
Published in Magnetic resonance in medicine (01-02-2018)“…Purpose To demonstrate how reference data affect the quantification of the apparent diffusion coefficient (ADC) in long diffusion time measurements with…”
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