Search Results - "Moller, Jv"

Interaction of membrane proteins and lipids with solubilizing detergents by le Maire, Marc, Champeil, Philippe, Møller, Jesper V

“…Detergents are indispensable in the isolation of integral membrane proteins from biological membranes to study their intrinsic structural and functional…”
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Phosphoryl Transfer and Calcium Ion Occlusion in the Calcium Pump by Sørensen, Thomas Lykke-Møller, Møller, Jesper Vuust, Nissen, Poul

“…A tight coupling between adenosine triphosphate (ATP) hydrolysis and vectorial ion transport has to be maintained by ATP-consuming ion pumps. We report two…”
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Dephosphorylation of the Calcium Pump Coupled to Counterion Occlusion by Olesen, Claus, Sørensen, Thomas Lykke-Møller, Nielsen, Rikke Christina, Møller, Jesper Vuust, Nissen, Poul

“…P-type ATPases extract energy by hydrolysis of adenosine triphosphate (ATP) in two steps, formation and breakdown of a covalent phosphoenzyme intermediate…”
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Purified E255L Mutant SERCA1a and Purified PfATP6 Are Sensitive to SERCA-type Inhibitors but Insensitive to Artemisinins by Cardi, Delphine, Pozza, Alexandre, Arnou, Bertrand, Marchal, Estelle, Clausen, Johannes D., Andersen, Jens Peter, Krishna, Sanjeev, Møller, Jesper V., le Maire, Marc, Jaxel, Christine

“…The antimalarial drugs artemisinins have been described as inhibiting Ca2+-ATPase activity of PfATP6 (Plasmodium falciparum ATP6) after expression in Xenopus…”
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Transport mechanism of the sarcoplasmic reticulum Ca2+ -ATPase pump by Møller, Jesper V, Nissen, Poul, Sørensen, Thomas L-M, le Maire, Marc

“…The sarcoplasmic reticulum Ca(2+)-ATPase (SERCA1a) belongs to the group of P-type ATPases, which actively transport inorganic cations across membranes at the…”
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The Mechanism of Detergent Solubilization of Liposomes and Protein-Containing Membranes by Kragh-Hansen, Ulrich, le Maire, Marc, Møller, Jesper V.

“…The present study explores intermediate stages in detergent solubilization of liposomes and Ca 2+-ATPase membranes by sodium dodecyl sulfate (SDS) and…”
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Crystallization of a Mammalian Membrane Protein Overexpressed in Saccharomyces cerevisiae by Jidenko, Marie, Nielsen, Rikke C., Sørensen, Thomas Lykke-Møller, Møller, Jesper V., le Maire, Marc, Nissen, Poul, Jaxel, Christine, Kaback, H. Ronald

“…The Ca2+- ATPase SERCA1a (sarcoplasmic-endoplasmic reticulum Ca2+- ATPase isoform 1a) from rabbit has been overexpressed in Saccharomyces cerevisiae. This…”
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Ca(2+) versus Mg(2+) Coordination at the Nucleotide-binding site of the Sarcoplasmic Reticulum Ca(2+)-ATPase by Picard, M., Jensen, Am, Sorensen, Tl, Champeil, P., Moller, Jv, Nissen, P.

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Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells by Søhoel, Helmer, Jensen, Anne-Marie Lund, Møller, Jesper V., Nissen, Poul, Denmeade, Samuel R., Isaacs, John T., Olsen, Carl Erik, Christensen, S. Brøgger

“…An analysis of the binding of the 8- O- N- tert-butoxycarbonyl-12-aminododecanoyl derivative of 8- O-debutanoylthapsigargin to the target molecule, the SERCA…”
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Detergents as Probes of Hydrophobic Binding Cavities in Serum Albumin and Other Water-Soluble Proteins by Kragh-Hansen, Ulrich, Hellec, Florence, de Foresta, Béatrice, le Maire, Marc, Møller, Jesper V.

“…As an extension of our studies on the interaction of detergents with membranes and membrane proteins, we have investigated their binding to water-soluble…”
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Structural studies of P-type ATPase-ligand complexes using an X-ray free-electron laser by Bublitz, Maike, Nass, Karol, Drachmann, Nikolaj D, Markvardsen, Anders J, Gutmann, Matthias J, Barends, Thomas R M, Mattle, Daniel, Shoeman, Robert L, Doak, R Bruce, Boutet, Sébastien, Messerschmidt, Marc, Seibert, Marvin M, Williams, Garth J, Foucar, Lutz, Reinhard, Linda, Sitsel, Oleg, Gregersen, Jonas L, Clausen, Johannes D, Boesen, Thomas, Gotfryd, Kamil, Wang, Kai-Tuo, Olesen, Claus, Møller, Jesper V, Nissen, Poul, Schlichting, Ilme

“…Membrane proteins are key players in biological systems, mediating signalling events and the specific transport of e.g. ions and metabolites. Consequently,…”
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Localization of a K+-binding Site Involved in Dephosphorylation of the Sarcoplasmic Reticulum Ca2+-ATPase by Sørensen, Thomas Lykke-Møller, Clausen, Johannes D, Jensen, Anne-Marie Lund, Vilsen, Bente, Møller, Jesper Vuust, Andersen, Jens Peter, Nissen, Poul

“…K + plays an important role for the function of the sarco(endo)plasmic reticulum Ca 2+ -ATPase (SERCA), but its binding site within the molecule has remained…”
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Protein-protein contact contacts in solubilized membrane proteins, as detected by cross-linking by Le Maire, M., Moller, Jv, Menguy, T., Velours, J., Champeil, P.

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Detergent Binding as a Sensor of Hydrophobicity and Polar Interactions in the Binding Cavities of Proteins by Peyre, Véronique, Lair, Virginie, André, Virginie, le Maire, Guerric, Kragh-Hansen, Ulrich, le Maire, Marc, Møller, Jesper V

“…To evaluate the role of hydrophobic and electrostatic or other polar interactions for protein−ligand binding, we studied the interaction of human serum albumin…”
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Structural organization, ion transport, and energy transduction of P-type ATPases by Møller, Jesper V, Juul, Birte, le Maire, Marc

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Crystal structure of D351A mutant forms of the mammalian sarcoplasmic reticulum CA2+-ATPase reveals key events in phosphorylation and CA2+ release by Manchand, A., Winther, Am, Holm, Pj, Olesen, C., Montigny, C., Arnou, B., Champeil, P., Clausen, Jd, Vilsen, B., Andersen, Jp, Nissen, P., Jaxel, C., Moller, Jv, Le Maire, M.

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Fe2+-catalyzed Oxidative Cleavages of Ca2+-ATPase Reveal Novel Features of Its Pumping Mechanism by Montigny, Cedric, Jaxel, Christine, Shainskaya, Alla, Vinh, Joëlle, Labas, Valérie, Møller, Jesper V, Karlish, Steven J D, le Maire, Marc

“…We have analyzed the Fe 2+ -catalyzed oxidative cleavages of Ca 2+ -ATPase in the presence of Ca 2+ , with or without the ATP analog…”
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The structural basis for coupling of Ca2+ transport to ATP hydrolysis by the sarcoplasmic reticulum Ca2+-ATPase by Møller, Jesper Vuust, Olesen, Claus, Jensen, Anne-Marie Lund, Nissen, Poul

“…Recently, a series of structure determinations has nearly completed a structural description of the transport cycle of the sarcoplasmic reticulum…”
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NMR studies of the fifth transmembrane segment of sarcoplasmic reticulum Ca2+‐ATPase reveals a hinge close to the Ca2+‐ligating residues by Nielsen, Gerd, Malmendal, Anders, Meissner, Axel, Møller, Jesper V, Nielsen, Niels Chr

“…Two recent X‐ray structures have tremendously increased the understanding of the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) and related proteins. Both…”
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Involvement of the L6-7 loop in SERCA1a Ca2+-ATPase activation by Ca2+ (or Sr2+) and ATP by Lenoir, Guillaume, Picard, Martin, Møller, Jesper V, le Maire, Marc, Champeil, Philippe, Falson, Pierre

“…Wild-type (WT) and the double mutant D813A,D818A (ADA) of the L6-7 loop of SERCA1a were expressed in yeast, purified, and reconstituted into lipids. This…”
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