Hospital and 1-Year Outcomes of Septic Syndromes in Older People: A Cohort Study

Purpose. Our objective was to describe the relationship between sepsis syndrome mortality and cognitive and physical disability in elderly persons. Methods. A 1-year consecutive cohort study in clinical beds of a university hospital was performed. Variables were severity of sepsis syndrome, organ fa...

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Published in:	The journals of gerontology. Series A, Biological sciences and medical sciences Vol. 63; no. 2; pp. 210 - 212
Main Authors:	Regazzoni, Carlos Javier, Zamora, Rafael Jose, Petrucci, Enrique, Pisarevsky, Ana Andrea, Saad, Ariel Karim, Mollein, Daniela De, Luna, Carlos Marcelo, Poderoso, Juan Jose
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press 01-02-2008
Subjects:	Age Aged Aged, 80 and over Argentina - epidemiology Cohort Studies Confidence intervals Critical care Failure Female Hospital Mortality Hospitalization Humans Male Mortality Multivariate analysis Nursing homes Older people Outcome Assessment (Health Care) Proportional Hazards Models Sepsis—Septic syndrome—Organ failure—Functional capacity Systemic Inflammatory Response Syndrome - mortality Argentina
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Summary:	Purpose. Our objective was to describe the relationship between sepsis syndrome mortality and cognitive and physical disability in elderly persons. Methods. A 1-year consecutive cohort study in clinical beds of a university hospital was performed. Variables were severity of sepsis syndrome, organ failure, functional status, age, sex, and positive cultures. Outcomes were in-hospital and 1-year mortalities. Results. The study included 137 patients (>70 years), both sexes. Data from 116 (84.5%) patients were obtainable at 1-year follow-up. Forty-eight (35%) patients presented with sepsis (11/137, 8%) or severe sepsis (37/137, 27%). In-hospital mortality was 15.3% (0% for sepsis and 21.8% if severe) and increased with organ failure (p <.0001). One-year mortality was 54.78% (63/116), mostly related to severe sepsis; predictors were severe organ failure (p <.0001), prior functional status (p =.0005), and Mini-Mental State Examination (p =.03). Prior functional status and organ failure were independent predictors. Conclusions. In-hospital and 1-year mortality increased with septic syndrome severity, prior functional status, and organ failure.
Bibliography:	href:210 istex:F3DBF174F7AB6F77E40CDBE60B1CEB40A5FF72C6 Address correspondence to Carlos Javier Regazzoni, MD, PhD, INECO, Centro de Estudios de la Memoria y Conducta, Castex 3293 (C1425CDC) Buenos Aires, Argentina. E-mail: cregazzoni@intramed.net ark:/67375/HXZ-W4N2PZ5Z-5 local:210 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1079-5006 1758-535X
DOI:	10.1093/gerona/63.2.210