Search Results - "Mollan, Todd L"

Development of recombinant hemoglobin-based oxygen carriers by Varnado, Cornelius L, Mollan, Todd L, Birukou, Ivan, Smith, Bryan J Z, Henderson, Douglas P, Olson, John S

“…The worldwide blood shortage has generated a significant demand for alternatives to whole blood and packed red blood cells for use in transfusion therapy. One…”
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The role of alpha-hemoglobin stabilizing protein in redox chemistry, denaturation, and hemoglobin assembly by Mollan, Todd L, Yu, Xiang, Weiss, Mitchell J, Olson, John S

“…Hemoglobin biosynthesis in erythrocyte precursors involves several steps. The correct ratios and concentrations of normal alpha (alpha) and beta (beta) globin…”
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Redox reactions of hemoglobin: mechanisms of toxicity and control by Mollan, Todd L, Alayash, Abdu I

“…In the last several years, significant work has been done studying hemoglobin (Hb) oxidative reactions and clearance mechanisms using both in vitro and in vivo…”
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Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin by Mollan, Todd L, Jia, Yiping, Banerjee, Sambuddha, Wu, Gang, Kreulen, R Timothy, Tsai, Ah-Lim, Olson, John S, Crumbliss, Alvin L, Alayash, Abdu I

“…Haptoglobin (Hp) is an abundant and conserved plasma glycoprotein, which binds acellular adult hemoglobin (Hb) dimers with high affinity and facilitates their…”
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Kinetics of α-Globin Binding to α-Hemoglobin Stabilizing Protein (AHSP) Indicate Preferential Stabilization of Hemichrome Folding Intermediate by Mollan, Todd L., Khandros, Eugene, Weiss, Mitchell J., Olson, John S.

“…Human α-hemoglobin stabilizing protein (AHSP) is a conserved mammalian erythroid protein that facilitates the production of Hemoglobin A by stabilizing free…”
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Post-translational transformation of methionine to aspartate is catalyzed by heme iron and driven by peroxide: a novel subunit-specific mechanism in hemoglobin by Strader, Michael Brad, Hicks, Wayne A, Kassa, Tigist, Singleton, Eileen, Soman, Jayashree, Olson, John S, Weiss, Mitchell J, Mollan, Todd L, Wilson, Michael T, Alayash, Abdu I

“…A pathogenic V67M mutation occurs at the E11 helical position within the heme pockets of variant human fetal and adult hemoglobins (Hb). Subsequent…”
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α-Hemoglobin Stabilizing Protein (AHSP) Markedly Decreases the Redox Potential and Reactivity of α-Subunits of Human HbA with Hydrogen Peroxide by Mollan, Todd L., Banerjee, Sambuddha, Wu, Gang, Parker Siburt, Claire J., Tsai, Ah-Lim, Olson, John S., Weiss, Mitchell J., Crumbliss, Alvin L., Alayash, Abdu I.

“…α-Hemoglobin stabilizing protein (AHSP) is a molecular chaperone that binds monomeric α-subunits of human hemoglobin A (HbA) and modulates heme iron oxidation…”
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Insights into Hemoglobin Assembly through in Vivo Mutagenesis of α-Hemoglobin Stabilizing Protein by Khandros, Eugene, Mollan, Todd L., Yu, Xiang, Wang, Xiaomei, Yao, Yu, D'Souza, Janine, Gell, David A., Olson, John S., Weiss, Mitchell J.

“…α-Hemoglobin stabilizing protein (AHSP) is believed to facilitate adult Hemoglobin A assembly and protect against toxic free α-globin subunits. Recombinant…”
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Analysis of human α globin gene mutations that impair binding to the α hemoglobin stabilizing protein by Yu, Xiang, Mollan, Todd L., Butler, Andrew, Gow, Andrew J., Olson, John S., Weiss, Mitchell J.

“…Alpha hemoglobin stabilizing protein (AHSP) reversibly binds nascent α globin to maintain its native structure and facilitate its incorporation into hemoglobin…”
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A Hemoglobin Variant Associated with Neonatal Cyanosis and Anemia by Crowley, Moira A, Mollan, Todd L, Abdulmalik, Osheisa Y, Butler, Andrew D, Goodwin, Emily F, Sarkar, Arindam, Stolle, Catherine A, Gow, Andrew J, Olson, John S, Weiss, Mitchell J

“…A novel mutation in a Gγ-globin gene (hemoglobin Toms River) causes transient neonatal cyanosis and anemia because of alterations in the oxygen-binding pocket…”
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α-Hemoglobin-stabilizing Protein (AHSP) Perturbs the Proximal Heme Pocket of Oxy-α-hemoglobin and Weakens the Iron-Oxygen Bond by Dickson, Claire F., Rich, Anne M., D'Avigdor, William M.H., Collins, Daniel A.T., Lowry, Jason A., Mollan, Todd L., Khandros, Eugene, Olson, John S., Weiss, Mitchell J., Mackay, Joel P., Lay, Peter A., Gell, David A.

“…α-Hemoglobin (αHb)-stabilizing protein (AHSP) is a molecular chaperone that assists hemoglobin assembly. AHSP induces changes in αHb heme coordination, but how…”
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Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α2β2Pro100Leu) by Mollan, Todd L., Abraham, Bindu, Strader, Michael Brad, Jia, Yiping, Lozier, Jay N., Olson, John S., Alayash, Abdu I.

“…Hemoglobin Brigham (β Pro100 to Leu) was first reported in a patient with familial erythrocytosis. Erythrocytes of an affected individual from the same family…”
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Post-translational Transformation of Methionine to Aspartate Is Catalyzed by Heme Iron and Driven by Peroxide by Strader, Michael Brad, Hicks, Wayne A., Kassa, Tigist, Singleton, Eileen, Soman, Jayashree, Olson, John S., Weiss, Mitchell J., Mollan, Todd L., Wilson, Michael T., Alayash, Abdu I.

“…A pathogenic V67M mutation occurs at the E11 helical position within the heme pockets of variant human fetal and adult hemoglobins (Hb). Subsequent…”
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A Hemoglobin Variant Associated with Neonatal Cyanosis and AnemiaBrief Report by Crowley, Moira A, Mollan, Todd L, Abdulmalik, Osheisa Y, Butler, Andrew D, Goodwin, Emily F, Sarkar, Arindam, Stolle, Catherine A, Gow, Andrew J, Olson, John S, Weiss, Mitchell J

“…Globin-gene mutations are a rare but important cause of cyanosis. We identified a missense mutation in the fetal Gγ-globin gene (HBG2 ) in a father and…”
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