Search Results - "Moll, Gert N."

Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19? by Namsolleck, Pawel, Moll, Gert N.

“…Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin…”
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Galanin 2 Receptor: A Novel Target for a Subset of Pancreatic Ductal Adenocarcinoma by Namsolleck, Pawel, Kofler, Barbara, Moll, Gert N

“…Galanin is a 30 amino acid peptide that stimulates three subtype receptors (GAL R). M89b is a lanthionine-stabilized, C-terminally truncated galanin analog…”
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Phage display and selection of lanthipeptides on the carboxy-terminus of the gene-3 minor coat protein by Urban, Johannes H., Moosmeier, Markus A., Aumüller, Tobias, Thein, Marcus, Bosma, Tjibbe, Rink, Rick, Groth, Katharina, Zulley, Moritz, Siegers, Katja, Tissot, Kathrin, Moll, Gert N., Prassler, Josef

“…Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an emerging class of natural products with drug-like properties. To fully…”
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Genetically Encoded Libraries of Constrained Peptides by Bosma, Tjibbe, Rink, Rick, Moosmeier, Markus A., Moll, Gert N.

“…Many therapeutic peptides can still be improved with respect to target specificity, target affinity, resistance to peptidases/proteases, physical stability,…”
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Efficacy of lanthionine-stabilized angiotensin-(1-7) in type I and type II diabetes mouse models by Kuipers, Anneke, Moll, Gert N., Wagner, Elizabeth, Franklin, Rick

“…•Lanthionine-stabilized angiotensin-(1–7) is effective in glycemic control.•cAng-(1–7) recovers insulin levels in mouse models of type I and II…”
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Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist by Wösten-van Asperen, Roelie M, Lutter, René, Specht, Patricia A, Moll, Gert N, van Woensel, Job B, van der Loos, Chris M, van Goor, Harry, Kamilic, Jelena, Florquin, Sandrine, Bos, Albert P

“…Acute respiratory distress syndrome (ARDS) is a devastating clinical syndrome. Angiotensin‐converting enzyme (ACE) and its effector peptide angiotensin (Ang)…”
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High-Throughput Screening for Substrate Specificity-Adapted Mutants of the Nisin Dehydratase NisB by Zhao, Xinghong, Cebrián, Rubén, Fu, Yuxin, Rink, Rick, Bosma, Tjibbe, Moll, Gert N, Kuipers, Oscar P

“…Microbial lanthipeptides are formed by a two-step enzymatic introduction of (methyl)lanthionine rings. A dehydratase catalyzes the dehydration of serine and…”
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Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage by Plat, Annechien, Kluskens, Leon D, Kuipers, Anneke, Rink, Rick, Moll, Gert N

“…Nisin A is a pentacyclic peptide antibiotic produced by Lactococcus lactis. The leader peptide of prenisin keeps nisin inactive and has a role in inducing…”
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Discovery, Production and Modification of Five Novel Lantibiotics Using the Promiscuous Nisin Modification Machinery by van Heel, Auke J, Kloosterman, Tomas G, Montalban-Lopez, Manuel, Deng, Jingjing, Plat, Annechien, Baudu, Baptiste, Hendriks, Djoke, Moll, Gert N, Kuipers, Oscar P

“…To find the right conditions to isolate natively expressed antimicrobial peptides from a wide range of different microorganisms can be a challenge. Here, we…”
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Mechanistic aspects of lanthipeptide leaders by Plat, Annechien, Kuipers, Anneke, Rink, Rick, Moll, Gert N

“…Lanthipeptides are ribosomally synthesized and posttranslationally modified peptides produced by microorganisms. The name lanthipeptide is derived from…”
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Angiotensin-(1-7) with thioether bridge: an angiotensin-converting enzyme-resistant, potent angiotensin-(1-7) analog by Kluskens, Leon D, Nelemans, S Adriaan, Rink, Rick, de Vries, Louwe, Meter-Arkema, Anita, Wang, Yong, Walther, Thomas, Kuipers, Anneke, Moll, Gert N, Haas, Marijke

“…The in vivo efficacy of many therapeutic peptides is hampered by their rapid proteolytic degradation. Cyclization of these therapeutic peptides is an excellent…”
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Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer by Moll, Gert N.

“…Pancreatic ductal adenocarcinoma (PDAC) remains a dreadful disease with poor prognosis. While the prognosis of colorectal carcinoma (CRC) is better than that…”
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Structure and Mechanism of the Lantibiotic Cyclase Involved in Nisin Biosynthesis by Li, Bo, Yu, John Paul J, Brunzelle, Joseph S, Moll, Gert N, Donk, Wilfred A. van der, Nair, Satish K

“…Nisin is a posttranslationally modified antimicrobial peptide that is widely used as a food preservative. It contains five cyclic thioethers of varying sizes…”
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Determining sites of interaction between prenisin and its modification enzymes NisB and NisC by Khusainov, Rustem, Heils, René, Lubelski, Jacek, Moll, Gert N., Kuipers, Oscar P.

“…Summary Although nisin is a model lantibiotic, our knowledge of the specific interactions of prenisin with its modification enzymes remains fragmentary. Here,…”
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Dissection and Modulation of the Four Distinct Activities of Nisin by Mutagenesis of Rings A and B and by C-Terminal Truncation by Rink, Rick, Wierenga, Jenny, Kuipers, Anneke, Kluskens, Leon D, Driessen, Arnold J.M, Kuipers, Oscar P, Moll, Gert N

“…Nisin A is a pentacyclic antibiotic peptide produced by various Lactococcus lactis strains. Nisin displays four different activities: (i) it autoinduces its…”
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Mutagenesis of nisin’s leader peptide proline strongly modulates export of precursor nisin by Plat, Annechien, Kuipers, Anneke, Crabb, Joe, Rink, Rick, Moll, Gert N.

“…The lantibiotic nisin is produced by Lactococcus lactis as a precursor peptide comprising a 23 amino acid leader peptide and a 34 amino acid…”
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Substrate Recognition and Specificity of the NisB Protein, the Lantibiotic Dehydratase Involved in Nisin Biosynthesis by Mavaro, Antonino, Abts, André, Bakkes, Patrick J., Moll, Gert N., Driessen, Arnold J.M., Smits, Sander H.J., Schmitt, Lutz

“…Nisin is a posttranslationally modified antimicrobial peptide containing the cyclic thioether amino acids lanthionine and methyllanthionine. Although much is…”
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Production of a Class II Two-Component Lantibiotic of Streptococcus pneumoniae Using the Class I Nisin Synthetic Machinery and Leader Sequence by MAJCHRZYKIEWICZ, Joanna A, LUBELSKI, Jacek, MOLL, Gert N, KUIPERS, Anneke, BIJLSMA, Jetta J. E, KUIPERS, Oscar P, RINK, Rick

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Bacterial Display and Screening of Posttranslationally Thioether-Stabilized Peptides by BOSMA, Tjibbe, KUIPERS, Anneke, BULTEN, Erna, DE VRIES, Louwe, RINK, Rick, MOLL, Gert N

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Microbial engineering of dehydro-amino acids and lanthionines in non-lantibiotic peptides by Moll, Gert N, Kuipers, Anneke, Rink, Rick

“…This minireview focusses on the use of bacteria to introduce dehydroresidues and (methyl)lanthionines in (poly)peptides. It mainly describes the broad…”
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