Search Results - "Molinuevo, Rut"

Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates by Xu, Adele Francis, Molinuevo, Rut, Fazzari, Elisa, Tom, Harrison, Zhang, Zijian, Menendez, Julien, Casey, Kerriann M, Ruggero, Davide, Hinck, Lindsay, Pritchard, Jonathan K, Barna, Maria

“…The formation of paralogs through gene duplication is a core evolutionary process. For paralogs that encode components of protein complexes such as the…”
Get full text

Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation by Molinuevo, Rut, Menendez, Julien, Cadle, Kora, Ariqat, Nabeela, Choy, Marie Klaire, Lagousis, Cayla, Thomas, Gwen, Strietzel, Catherine, Bubolz, J. W., Hinck, Lindsay

“…Lactation insufficiency affects many women worldwide. During lactation, a large portion of mammary gland alveolar cells become polyploid, but how these cells…”
Get full text

Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint by Galán-Vidal, Jesús, García-Gaipo, Lorena, Molinuevo, Rut, Dias, Samantha, Tsoi, Alex, Gómez-Román, Javier, Elder, James T., Hochegger, Helfrid, Gandarillas, Alberto

“…Squamous or epidermoid cancer arises in stratified epithelia but also is frequent in the non-epidermoid epithelium of the lung by unclear mechanisms. A poorly…”
Get full text

Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic Slippage by Freije, Ana, Molinuevo, Rut, Ceballos, Laura, Cagigas, Marta, Alonso-Lecue, Pilar, Rodriguez, René, Menendez, Pablo, Aberdam, Daniel, De Diego, Ernesto, Gandarillas, Alberto

“…Tumor suppressor p53 is a major cellular guardian of genome integrity, and its inactivation is the most frequent genetic alteration in cancer, rising up to 80%…”
Get full text

Nuclear VANGL2 Inhibits Lactogenic Differentiation by Rubio, Stefany, Molinuevo, Rut, Sanz-Gomez, Natalia, Zomorrodinia, Talieh, Cockrum, Chad S, Luong, Elina, Rivas, Lucia, Cadle, Kora, Menendez, Julien, Hinck, Lindsay

“…Planar cell polarity (PCP) proteins coordinate tissue morphogenesis by governing cell patterning and polarity. Asymmetrically localized on the plasma membrane…”
Get full text

Mammalian endoreplication emerges to reveal a potential developmental timer by Gandarillas, Alberto, Molinuevo, Rut, Sanz-Gómez, Natalia

“…Among the most intriguing and relevant questions in physiology is how developing tissues correctly coordinate proliferation with differentiation…”
Get full text

The DNA damage response links human squamous proliferation with differentiation by Molinuevo, Rut, Freije, Ana, Contreras, Lizbeth, Sanz, Juan R, Gandarillas, Alberto

“…How rapid cell multiplication leads to cell differentiation in developing tissues is still enigmatic. This question is central to morphogenesis, cell number…”
Get full text

SLIT Loss or Sequestration Increases Mammary Alveologenesis and Lactogenesis by Cazares, Oscar, Chen, Min, Menendez, Julien, Molinuevo, Rut, Thomas, Gwen, Cervantes, Jocelyn, Yee, Michael, Cadell, Michael, Durham, Megan, Zhu, Yaqi, Strietzel, Catherine, Bubolz, Jacob W, Hinck, Lindsay

“…SLITs comprise a family of secreted proteins that function as ligands for Roundabout (ROBO) receptors. Previous research showed that ROBO1 promotes the…”
Get full text

The mitosis-differentiation checkpoint, another guardian of the epidermal genome by Gandarillas, Alberto, Molinuevo, Rut, Freije, Ana, Alonso-Lecue, Pilar

“…The role of p53, the original "guardian of the genome", in skin has remained elusive. We have explored p53 function in human epidermal cells and demonstrated…”
Get full text

Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells by Alonso-Lecue, Pilar, de Pedro, Isabel, Coulon, Vincent, Molinuevo, Rut, Lorz, Corina, Segrelles, Carmen, Ceballos, Laura, López-Aventín, Daniel, García-Valtuille, Ana, Bernal, José M, Mazorra, Francisco, Pujol, Ramón M, Paramio, Jesús, Ramón Sanz, J, Freije, Ana, Toll, Agustí, Gandarillas, Alberto

“…Squamous cell carcinoma (SCC) or epidermoid cancer is a frequent and aggressive malignancy. However in apparent paradox it retains the squamous differentiation…”
Get full text