Search Results - "Molinuevo, Jose"
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Dementia care during COVID-19
Published in The Lancet (British edition) (11-04-2020)“…According to an interactive online tool that estimates the potential number of deaths from COVID-19 in a population, by age group, in individual countries and…”
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Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance
Published in Neurobiology of aging (2012)“…Abstract White matter (WM) damage has been reported in Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) in diffusion tensor imaging (DTI) studies…”
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3
The characterisation of subjective cognitive decline
Published in Lancet neurology (01-03-2020)“…A growing awareness about brain health and Alzheimer's disease in the general population is leading to an increasing number of cognitively unimpaired…”
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The clinical use of cerebrospinal fluid biomarker testing for Alzheimer's disease diagnosis: A consensus paper from the Alzheimer's Biomarkers Standardization Initiative
Published in Alzheimer's & dementia (01-11-2014)“…Abstract Background Cerebrospinal fluid (CSF) biomarkers β-amyloid 1-42 (Aβ1-42 ), also expressed as Aβ1-42 :Aβ1-40 ratio, T-tau, and P-tau181P , have proven…”
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Drug repositioning and repurposing for Alzheimer disease
Published in Nature reviews. Neurology (01-12-2020)“…Drug repositioning and repurposing can enhance traditional drug development efforts and could accelerate the identification of new treatments for individuals…”
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Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project
Published in The Lancet. Psychiatry (01-02-2016)“…Summary Alzheimer's dementia affects more than 40 million people worldwide with substantial increases in prevalence anticipated. Interventions that either…”
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Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials
Published in JAMA : the journal of the American Medical Association (09-01-2018)“…IMPORTANCE: New therapeutic approaches for Alzheimer disease (AD) are needed. OBJECTIVE: To assess whether idalopirdine, a selective 5-hydroxytryptamine-6…”
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Is there a difference in regional read [18F]flutemetamol amyloid patterns between end-of-life subjects and those with amnestic mild cognitive impairment?
Published in European journal of nuclear medicine and molecular imaging (01-06-2019)“…Purpose Visual interpretation of PET [ 18 F]flutemetamol images relies on systematic review of five brain regions and is considered positive when an elevated…”
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Effect of long-term exposure to air pollution on anxiety and depression in adults: A cross-sectional study
Published in International journal of hygiene and environmental health (01-08-2017)“…The association between exposure to air pollutants and mental disorders among adults has been suggested, although results are not consistent. To analyze the…”
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Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease
Published in Annals of neurology (01-11-2013)“…Objective To identify a novel biochemical marker that precedes clinical symptoms in Alzheimer disease (AD). Methods Using quantitative polymerase chain…”
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Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimer’s disease
Published in Therapeutic Advances in Neurological Disorders (2019)“…Alzheimer’s disease (AD) is the most common neurodegenerative disease and its diagnosis has classically been based on clinical symptoms. Recently, a biological…”
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Alzheimer's disease prevention: from risk factors to early intervention
Published in Alzheimer's research & therapy (12-09-2017)“…Due to the progressive aging of the population, Alzheimer's disease (AD) is becoming a healthcare burden of epidemic proportions for which there is currently…”
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Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinson's disease
Published in Journal of neuroscience research (01-08-2014)“…Blood‐cell‐free circulating micro‐RNAs (miRNAs) have been proposed as potential accessible biomarkers for neurodegenerative diseases such as Parkinson's…”
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White matter changes in preclinical Alzheimer's disease: a magnetic resonance imaging-diffusion tensor imaging study on cognitively normal older people with positive amyloid β protein 42 levels
Published in Neurobiology of aging (01-12-2014)“…Abstract The aim of this study was to use diffusion tensor imaging measures to determine the existence of white matter microstructural differences in the…”
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Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases
Published in Nature reviews. Neurology (01-01-2015)“…Key Points Cerebrospinal fluid (CSF) biomarkers can track relevant pathophysiological changes that occur in the brains of patients with Alzheimer disease (AD)…”
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Multipurpose Virtual Reality Environment for Biomedical and Health Applications
Published in IEEE transactions on neural systems and rehabilitation engineering (01-08-2019)“…Virtual reality is a trending, widely accessible, and contemporary technology of increasing utility to biomedical and health applications. However, most…”
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Perspectives on Communicating Biomarker-Based Assessments of Alzheimer's Disease to Cognitively Healthy Individuals
Published in Journal of Alzheimer's disease (01-01-2018)“…In clinical trials which target pathophysiological mechanisms associated with Alzheimer's disease, research participants who are recruited based on biomarker…”
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Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent
Published in European journal of nuclear medicine and molecular imaging (01-07-2021)“…Purpose To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. Methods [ 18…”
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Plasma miR-34a-5p and miR-545-3p as Early Biomarkers of Alzheimer’s Disease: Potential and Limitations
Published in Molecular neurobiology (01-09-2017)“…Plasma microRNAs (miRNAs) have been proposed as potential biomarkers in Alzheimer’s disease (AD). Here, we explored their use as early sensors of the…”
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A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease
Published in Neurobiology of aging (01-07-2013)“…Abstract Alzheimer's disease (AD) is the most common neurodegenerative dementia. Approximately 10% of cases present at an age of onset before 65 years old,…”
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