Search Results - "Molinero, Amalia"

Role of muscle IL-6 in gender-specific metabolism in mice by Molinero, Amalia, Fernandez-Perez, Antonio, Mogas, Aina, Giralt, Mercedes, Comes, Gemma, Fernandez-Gayol, Olaya, Vallejo, Mario, Hidalgo, Juan

“…The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out…”
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IL-6 trans-signaling in the brain influences the behavioral and physio-pathological phenotype of the Tg2576 and 3xTgAD mouse models of Alzheimer’s disease by Escrig, Anna, Canal, Carla, Sanchis, Paula, Fernández-Gayol, Olaya, Montilla, Alejandro, Comes, Gemma, Molinero, Amalia, Giralt, Mercedes, Giménez-Llort, Lydia, Becker-Pauly, Christoph, Rose-John, Stefan, Hidalgo, Juan

“…[Display omitted] •AD-induced mortality was reversed by the inhibition of IL-6 trans-signaling.•The inhibition of IL-6 trans-signaling modulated some…”
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Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures by Penkowa, Milena, Florit, Sergi, Giralt, Mercedes, Quintana, Albert, Molinero, Amalia, Carrasco, Javier, Hidalgo, Juan

“…We examined metallothionein (MT)‐induced neuroprotection during kainic acid (KA)‐induced excitotoxicity by studying transgenic mice with MT‐I overexpression…”
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Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer's Disease by Comes, Gemma, Manso, Yasmina, Escrig, Anna, Fernandez-Gayol, Olaya, Sanchis, Paula, Molinero, Amalia, Giralt, Mercedes, Carrasco, Javier, Hidalgo, Juan

“…The mouse model of Alzheimer's disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their…”
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Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury by Pifarré, Paula, Prado, Judith, Giralt, Mercedes, Molinero, Amalia, Hidalgo, Juan, Garcia, Agustina

“…J. Neurochem. (2010) 112, 807-817. Recent evidence obtained in cultured glial cells indicates that cGMP-mediated pathways regulate cytoskeleton dynamics, glial…”
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IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease by Escrig, Anna, Molinero, Amalia, Méndez, Brenda, Giralt, Mercedes, Comes, Gemma, Sanchis, Paula, Fernández-Gayol, Olaya, Giménez-Llort, Lydia, Becker-Pauly, Christoph, Rose-John, Stefan, Hidalgo, Juan

“…Alzheimer's disease (AD) is a neurodegenerative disorder that causes the most prevalent dementia in the elderly people. Obesity and insulin resistance, which…”
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Astrocytic IL-6 Influences the Clinical Symptoms of EAE in Mice by Erta, Maria, Giralt, Mercedes, Jiménez, Silvia, Molinero, Amalia, Comes, Gemma, Hidalgo, Juan

“…Interleukin-6 (IL-6) is a multifunctional cytokine that not only plays major roles in the immune system, but also serves as a coordinator between the nervous…”
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Metallothionein-1+2 Protect the CNS after a Focal Brain Injury by Giralt, Mercedes, Penkowa, Milena, Lago, Natalia, Molinero, Amalia, Hidalgo, Juan

“…We have evaluated the physiological relevance of metallothionein-1+2 (MT-1+2) in the CNS following damage caused by a focal cryolesion onto the cortex. In…”
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Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation by Hidalgo, Juan, Penkowa, Milena, Espejo, Carmen, Martínez-Cáceres, Eva M, Carrasco, Javier, Quintana, Albert, Molinero, Amalia, Florit, Sergi, Giralt, Mercedes, Ortega-Aznar, Arantxa

“…In recent years it has become increasingly clear that the metallothionein (MT) family of proteins is important in neurobiology. MT-I and MT-II are normally…”
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Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: Insights from global gene expression profiling in wild-type and MT-I + II knockout mice by Penkowa, Milena, Cáceres, Mario, Borup, Rehannah, Nielsen, Finn Cilius, Poulsen, Christian Bjørn, Quintana, Albert, Molinero, Amalia, Carrasco, Javier, Florit, Sergi, Giralt, Mercedes, Hidalgo, Juan

“…Traumatic injury to the brain is one of the leading causes of injury‐related death or disability, especially among young people. Inflammatory processes and…”
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Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice by Carrasco, Javier, Penkowa, Milena, Hadberg, Hanne, Molinero, Amalia, Hidalgo, Juan

“…Metallothioneins (MTs) are major zinc binding proteins in the CNS that could be involved in the control of zinc metabolism as well as in protection against…”
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Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice by Penkowa, Milena, Moos, Torben, Carrasco, Javier, Hadberg, Hanne, Molinero, Amalia, Bluethmann, Horst, Hidalgo, Juan

“…Injury to the central nervous system (CNS) elicits an inflammatory response involving activation of microglia, brain macrophages, and astrocytes, processes…”
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Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide by Penkowa, Milena, Camats, Jordi, Hadberg, Hanne, Quintana, Albert, Rojas, Santiago, Giralt, Mercedes, Molinero, Amalia, Campbell, Iain L., Hidalgo, Juan

“…6‐Aminonicotinamide (6‐AN) is a niacin antagonist, which leads to degeneration of gray matter astrocytes mainly in the brainstem. We have examined the role of…”
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Brain response to traumatic brain injury in wild‐type and interleukin‐6 knockout mice: a microarray analysis by Poulsen, Christian Bjørn, Penkowa, Milena, Borup, Rehannah, Nielsen, Finn Cilius, Cáceres, Mario, Quintana, Albert, Molinero, Amalia, Carrasco, Javier, Giralt, Mercedes, Hidalgo, Juan

“…Traumatic injury to the brain is one of the leading causes of injury‐related death or disability. Brain response to injury is orchestrated by cytokines, such…”
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Altered Central Nervous System Cytokine-Growth Factor Expression Profiles and Angiogenesis in Metallothionein-I+II Deficient Mice by Penkowa, Milena, Carrasco, Javier, Giralt, Mercedes, Molinero, Amalia, Hernández, Joaquín, Campbell, Iain L., Hidalgo, Juan

“…To study the importance of metallothionein-I and -II (MT-I+II) for brain inflammation and regeneration, the authors examined normal and MT-I+II knock-out…”
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Role of metallothionein-III following central nervous system damage by Carrasco, Javier, Penkowa, Milena, Giralt, Mercedes, Camats, Jordi, Molinero, Amalia, Campbell, Iain L., Palmiter, Richard D., Hidalgo, Juan

“…We evaluated the physiological relevance of metallothionein-III (MT-III) in the central nervous system following damage caused by a focal cryolesion onto the…”
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Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6 by Giralt, Mercedes, Penkowa, Milena, Hernández, Joaquín, Molinero, Amalia, Carrasco, Javier, Lago, Natalia, Camats, Jordi, Campbell, Iain L, Hidalgo, Juan

“…Transgenic expression of IL-6 under the control of the GFAP gene promoter (GFAP-IL6 mice) in the CNS causes significant damage and alters the expression of…”
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Microglial cell‐derived interleukin‐6 influences behavior and inflammatory response in the brain following traumatic brain injury by Sanchis, Paula, Fernández‐Gayol, Olaya, Vizueta, Joel, Comes, Gemma, Canal, Carla, Escrig, Anna, Molinero, Amalia, Giralt, Mercedes, Hidalgo, Juan

“…Traumatic brain injury (TBI) is a major health problem with high rates of mortality and morbidity worldwide. The response of the brain to TBI is orchestrated…”
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Astrocyte-targeted expression of IL-6 protects the CNSagainst a focal brain injury by Penkowa, Milena, Giralt, Mercedes, Lago, Natalia, Camats, Jordi, Carrasco, Javier, Hernández, Joaquin, Molinero, Amalia, Campbell, Iain L, Hidalgo, Juan

“…The effect of CNS-targeted IL-6 gene expression has been thoroughly investigated in the otherwise nonperturbed brain but not following brain injury. Here we…”
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Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE by Comes, Gemma, Fernandez-Gayol, Olaya, Molinero, Amalia, Giralt, Mercedes, Capdevila, Mercè, Atrian, Silvia, Hidalgo, Juan

“…Mouse metallothionein-1 and 2 (MT1 and MT2) are often considered physiologically equivalent, because they are normally regulated coordinately by a wide range…”
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