Search Results - "Molinari, Maurizio"

N-glycan structure dictates extension of protein folding or onset of disposal by Molinari, Maurizio

“…The endoplasmic reticulum (ER) is the site of folding for proteins that are resident in the ER or that are destined for the Golgi, endosomes, lysosomes, the…”
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Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways by Fregno, Ilaria, Molinari, Maurizio

“…About 40% of the eukaryotic cell's proteins are inserted co- or post-translationally in the endoplasmic reticulum (ER), where they attain the native structure…”
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ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress by Loi, Marisa, Raimondi, Andrea, Morone, Diego, Molinari, Maurizio

“…The endoplasmic reticulum (ER) produces about 40% of the nucleated cell’s proteome. ER size and content in molecular chaperones increase upon physiologic and…”
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In and Out of the ER: Protein Folding, Quality Control, Degradation, and Related Human Diseases by Hebert, Daniel N, Molinari, Maurizio

“…Institute for Research in Biomedicine, Bellinzona, Switzerland; and Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular…”
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ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER by Bernasconi, Riccardo, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is the site of maturation for secretory and membrane proteins in eukaryotic cells. Unsuccessful folding attempts are eventually…”
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N‐glycan processing selects ERAD‐resistant misfolded proteins for ER‐to‐lysosome‐associated degradation by Fregno, Ilaria, Fasana, Elisa, Soldà, Tatiana, Galli, Carmela, Molinari, Maurizio

“…Efficient degradation of by‐products of protein biogenesis maintains cellular fitness. Strikingly, the major biosynthetic compartment in eukaryotic cells, the…”
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Endoplasmic reticulum turnover: ER-phagy and other flavors in selective and non-selective ER clearance [version 1; peer review: 2 approved] by Fregno, Ilaria, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells. It is deputed to lipid and protein biosynthesis, calcium storage, and the…”
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Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery by Fumagalli, Fiorenza, Noack, Julia, Bergmann, Timothy J., Cebollero, Eduardo, Pisoni, Giorgia Brambilla, Fasana, Elisa, Fregno, Ilaria, Galli, Carmela, Loi, Marisa, Soldà, Tatiana, D’Antuono, Rocco, Raimondi, Andrea, Jung, Martin, Melnyk, Armin, Schorr, Stefan, Schreiber, Anne, Simonelli, Luca, Varani, Luca, Wilson-Zbinden, Caroline, Zerbe, Oliver, Hofmann, Kay, Peter, Matthias, Quadroni, Manfredo, Zimmermann, Richard, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the…”
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N-glycan processing in ER quality control by Ruddock, Lloyd W, Molinari, Maurizio

“…Glycosylation of asparagine residues in Asn-x-Ser/Thr motifs is a common covalent modification of proteins in the lumen of the endoplasmic reticulum (ER). By…”
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Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates by Bernasconi, Riccardo, Galli, Carmela, Calanca, Verena, Nakajima, Toshihiro, Molinari, Maurizio

“…Sophisticated quality control mechanisms prolong retention of protein-folding intermediates in the endoplasmic reticulum (ER) until maturation while sorting…”
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Five Questions (with their Answers) on ER‐Associated Degradation by Brambilla Pisoni, Giorgia, Molinari, Maurizio

“…Production of a functional proteome is a major burden for our cells. Native proteins operate inside and outside the cells to eventually warrant life and…”
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Glycoprotein folding and the role of EDEM1, EDEM2 and EDEM3 in degradation of folding-defective glycoproteins by Olivari, Silvia, Molinari, Maurizio

“…Proteins synthesized in the endoplasmic reticulum (ER) lumen are exposed to several dedicated chaperones and folding factors that ensure efficient maturation…”
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How viruses hijack the ERAD tuning machinery by Noack, Julia, Bernasconi, Riccardo, Molinari, Maurizio

“…An essential step during the intracellular life cycle of many positive-strand RNA viruses is the rearrangement of host cell membranes to generate…”
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Deep learning approach for quantification of organelles and misfolded polypeptide delivery within degradative compartments by Morone, Diego, Marazza, Alessandro, Bergmann, Timothy J., Molinari, Maurizio

“…LysoQuant is a deep learning approach to segmentation and classification of fluorescent images capturing cargo delivery within endolysosomes for clearance. It…”
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TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress by Kucińska, Marika K., Fedry, Juliette, Galli, Carmela, Morone, Diego, Raimondi, Andrea, Soldà, Tatiana, Förster, Friedrich, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is an organelle of nucleated cells that produces proteins, lipids and oligosaccharides. ER volume and activity are increased…”
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Thioredoxin-Related Transmembrane Proteins: TMX1 and Little Brothers TMX2, TMX3, TMX4 and TMX5 by Guerra, Concetta, Molinari, Maurizio

“…The endoplasmic reticulum (ER) is site of synthesis and maturation of membrane and secretory proteins in eukaryotic cells. The ER contains more than 20 members…”
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Tau accumulation in degradative organelles is associated to lysosomal stress by Piovesana, Ester, Magrin, Claudia, Ciccaldo, Matteo, Sola, Martina, Bellotto, Manolo, Molinari, Maurizio, Papin, Stéphanie, Paganetti, Paolo

“…Neurodegenerative disorders are characterized by the brain deposition of insoluble amyloidogenic proteins, such as α-synuclein or Tau, and the concomitant…”
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Identification of signal peptide features for substrate specificity in human Sec62/Sec63‐dependent ER protein import by Schorr, Stefan, Nguyen, Duy, Haßdenteufel, Sarah, Nagaraj, Nagarjuna, Cavalié, Adolfo, Greiner, Markus, Weissgerber, Petra, Loi, Marisa, Paton, Adrienne W., Paton, James C., Molinari, Maurizio, Förster, Friedrich, Dudek, Johanna, Lang, Sven, Helms, Volkhard, Zimmermann, Richard

“…In mammalian cells, one‐third of all polypeptides are integrated into the membrane or translocated into the lumen of the endoplasmic reticulum (ER) via the…”
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Selective involvement of UGGT variant: UGGT2 in protecting mouse embryonic fibroblasts from saturated lipid-induced ER stress by Hung, Hui-Hsing, Nagatsuka, Yasuko, Soldà, Tatiana, Kodali, Vamsi K, Iwabuchi, Kazuhisa, Kamiguchi, Hiroyuki, Kano, Koki, Matsuo, Ichiro, Ikeda, Kazutaka, Kaufman, Randal J, Molinari, Maurizio, Greimel, Peter, Hirabayashi, Yoshio

“…Secretory proteins and lipids are biosynthesized in the endoplasmic reticulum (ER). The "protein quality control" system (PQC) monitors glycoprotein folding…”
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Specificity and Regulation of the Endoplasmic Reticulum‐Associated Degradation Machinery by Merulla, Jessica, Fasana, Elisa, Soldà, Tatiana, Molinari, Maurizio

“…The endoplasmic reticulum‐associated degradation (ERAD) machinery selects native and misfolded polypeptides for dislocation across the ER membrane and…”
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