Search Results - "Molina‐Espeja, Patricia"

Directed evolution of unspecific peroxygenase in organic solvents by Martin‐Diaz, Javier, Molina‐Espeja, Patricia, Hofrichter, Martin, Hollmann, Frank, Alcalde, Miguel

“…Fungal unspecific peroxygenases (UPOs) are efficient biocatalysts that insert oxygen atoms into nonactivated C–H bonds with high selectivity. Many…”
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Engineering a Highly Regioselective Fungal Peroxygenase for the Synthesis of Hydroxy Fatty Acids by Gomez de Santos, Patricia, González‐Benjumea, Alejandro, Fernandez‐Garcia, Angela, Aranda, Carmen, Wu, Yinqi, But, Andrada, Molina‐Espeja, Patricia, Maté, Diana M., Gonzalez‐Perez, David, Zhang, Wuyuan, Kiebist, Jan, Scheibner, Katrin, Hofrichter, Martin, Świderek, Katarzyna, Moliner, Vicent, Sanz‐Aparicio, Julia, Hollmann, Frank, Gutiérrez, Ana, Alcalde, Miguel

“…The hydroxylation of fatty acids is an appealing reaction in synthetic chemistry, although the lack of selective catalysts hampers its industrial…”
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Next Generation Winemakers: Genetic Engineering in Saccharomyces cerevisiae for Trendy Challenges by Molina-Espeja, Patricia

“…The most famous yeast of all, Saccharomyces cerevisiae, has been used by humankind for at least 8000 years, to produce bread, beer and wine, even without…”
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Synthesis of 1-Naphthol by a Natural Peroxygenase Engineered by Directed Evolution by Molina-Espeja, Patricia, Cañellas, Marina, Plou, Francisco J., Hofrichter, Martin, Lucas, Fatima, Guallar, Victor, Alcalde, Miguel

“…There is an increasing interest in enzymes that catalyze the hydroxylation of naphthalene under mild conditions and with minimal requirements. To address this…”
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Mutagenic Organized Recombination Process by Homologous IN vivo Grouping (MORPHING) for directed enzyme evolution by Gonzalez-Perez, David, Molina-Espeja, Patricia, Garcia-Ruiz, Eva, Alcalde, Miguel

“…Approaches that depend on directed evolution require reliable methods to generate DNA diversity so that mutant libraries can focus on specific target regions…”
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Structure-Guided Immobilization of an Evolved Unspecific Peroxygenase by Molina-Espeja, Patricia, Santos-Moriano, Paloma, García-Ruiz, Eva, Ballesteros, Antonio, Plou, Francisco J, Alcalde, Miguel

“…Unspecific peroxygenases (UPOs) are highly promiscuous biocatalyst with self-sufficient mono(per)oxygenase activity. A laboratory-evolved UPO secreted by yeast…”
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Mapping Potential Determinants of Peroxidative Activity in an Evolved Fungal Peroxygenase from Agrocybe aegerita by Molina-Espeja, Patricia, Beltran-Nogal, Alejandro, Alfuzzi, Maria Alejandra, Guallar, Victor, Alcalde, Miguel

“…Fungal unspecific peroxygenases (UPOs) are hybrid biocatalysts with peroxygenative activity that insert oxygen into non-activated compounds, while also…”
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Corrigendum: Mapping Potential Determinants of Peroxidative Activity in an Evolved Fungal Peroxygenase From Agrocybe aegerita by Molina-Espeja, Patricia, Beltran-Nogal, Alejandro, Alfuzzi, Maria Alejandra, Guallar, Victor, Alcalde, Miguel

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Engineering a Highly Regioselective Fungal Peroxygenase for the Synthesis of Hydroxy Fatty Acids by Gomez de Santos, Patricia, González‐Benjumea, Alejandro, Fernandez‐Garcia, Angela, Aranda, Carmen, Wu, Yinqi, But, Andrada, Molina‐Espeja, Patricia, Maté, Diana M., Gonzalez‐Perez, David, Zhang, Wuyuan, Kiebist, Jan, Scheibner, Katrin, Hofrichter, Martin, Świderek, Katarzyna, Moliner, Vicent, Sanz‐Aparicio, Julia, Hollmann, Frank, Gutiérrez, Ana, Alcalde, Miguel

“…The hydroxylation of fatty acids is an appealing reaction in synthetic chemistry, although the lack of selective catalysts hampers its industrial…”
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Tandem-yeast expression system for engineering and producing unspecific peroxygenase by Molina-Espeja, Patricia, Ma, Su, Mate, Diana M., Ludwig, Roland, Alcalde, Miguel

“…•Unspecific peroxygenases (UPOs) are promising biocatalysts for organic synthesis.•Directed evolution and large scale production are required for UPO…”
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Directed evolution of unspecific peroxygenase from Agrocybe aegerita by Molina-Espeja, Patricia, Garcia-Ruiz, Eva, Gonzalez-Perez, David, Ullrich, René, Hofrichter, Martin, Alcalde, Miguel

“…Unspecific peroxygenase (UPO) represents a new type of heme-thiolate enzyme with self-sufficient mono(per)oxygenase activity and many potential applications in…”
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Shuffling the Neutral Drift of Unspecific Peroxygenase in Saccharomyces cerevisiae by Martin-Diaz, Javier, Paret, Carmen, García-Ruiz, Eva, Molina-Espeja, Patricia, Alcalde, Miguel

“…Unspecific peroxygenase (UPO) is a highly promiscuous biocatalyst, and its selective mono(per)oxygenase activity makes it useful for many synthetic chemistry…”
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Structural Insights into the Substrate Promiscuity of a Laboratory-Evolved Peroxygenase by Ramirez-Escudero, Mercedes, Molina-Espeja, Patricia, Gomez de Santos, Patricia, Hofrichter, Martin, Sanz-Aparicio, Julia, Alcalde, Miguel

“…Because of their minimal requirements, substrate promiscuity and product selectivity, fungal peroxygenases are now considered to be the jewel in the crown of…”
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Selective Synthesis of the Human Drug Metabolite 5′-Hydroxypropranolol by an Evolved Self-Sufficient Peroxygenase by Gomez de Santos, Patricia, Cañellas, Marina, Tieves, Florian, Younes, Sabry H. H, Molina-Espeja, Patricia, Hofrichter, Martin, Hollmann, Frank, Guallar, Victor, Alcalde, Miguel

“…Propranolol is a widely used beta-blocker that is metabolized by human liver P450 monooxygenases into equipotent hydroxylated human drug metabolites (HDMs). It…”
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Modification of the peroxygenative:peroxidative activity ratio in the unspecific peroxygenase from Agrocybe aegerita by structure-guided evolution by Mate, Diana M., Palomino, Miguel A., Molina-Espeja, Patricia, Martin-Diaz, Javier, Alcalde, Miguel

“…Abstract Unspecific peroxygenase (UPO) is a heme-thiolate peroxidase capable of performing with high-selectivity C-H oxyfunctionalizations of great interest in…”
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Beyond the outer limits of nature by directed evolution by Molina-Espeja, Patricia, Viña-Gonzalez, Javier, Gomez-Fernandez, Bernardo J, Martin-Diaz, Javier, Garcia-Ruiz, Eva, Alcalde, Miguel

“…For more than thirty years, biotechnology has borne witness to the power of directed evolution in designing molecules of industrial relevance. While scientists…”
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Mutagenic Organized Recombination Process by Homologous In Vivo Grouping by Gonzalez-Perez, David, Molina-Espeja, Patricia, Garcia-Ruiz, Eva, Alcalde, Miguel

“…Approaches that depend on directed evolution require reliable methods to generate DNA diversity so that mutant libraries can focus on specific target regions…”
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Enzymes for consumer products to achieve climate neutrality by Molina-Espeja, Patricia, Sanz-Aparicio, Julia, Golyshin, Peter N, Robles-Martín, Ana, Guallar, Víctor, Beltrametti, Fabrizio, Müller, Markus, Yakimov, Michail M, Modregger, Jan, van Logchem, Moniec, Corvini, Philippe, Shahgaldian, Patrick, Degering, Christian, Wieland, Susanne, Timm, Anne, de Carvalho, Carla C C R, Re, Ilaria, Daniotti, Sara, Thies, Stephan, Jaeger, Karl-Erich, Chow, Jennifer, Streit, Wolfgang R, Lottenbach, Roland, Rösch, Rainer, Ansari, Nazanin, Ferrer, Manuel

“…Abstract Today, the chemosphere’s and biosphere’s compositions of the planet are changing faster than experienced during the past thousand years. CO2 emissions…”
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Mutagenic Organized Recombination Process by Homologous In Vivo Grouping (MORPHING) for Directed Enzyme Evolution: e90919 by Gonzalez-Perez, David, Molina-Espeja, Patricia, Garcia-Ruiz, Eva, Alcalde, Miguel

“…Approaches that depend on directed evolution require reliable methods to generate DNA diversity so that mutant libraries can focus on specific target regions…”
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