Search Results - "Molina, Eric R."

IGF-1R/mTOR Targeted Therapy for Ewing Sarcoma: A Meta-Analysis of Five IGF-1R-Related Trials Matched to Proteomic and Radiologic Predictive Biomarkers by Amin, Hesham M, Morani, Ajaykumar C, Daw, Najat C, Lamhamedi-Cherradi, Salah-Eddine, Subbiah, Vivek, Menegaz, Brian A, Vishwamitra, Deeksha, Eskandari, Ghazaleh, George, Bhawana, Benjamin, Robert S, Patel, Shreyaskumar, Song, Juhee, Lazar, Alexander J, Wang, Wei-Lien, Kurzrock, Razelle, Pappo, Alberto, Anderson, Peter M, Schwartz, Gary K, Araujo, Dejka, Cuglievan, Branko, Ratan, Ravin, McCall, David, Mohiuddin, Sana, Livingston, John A, Molina, Eric R, Naing, Aung, Ludwig, Joseph A

“…: Ten to fourteen percent of Ewing sarcoma (ES) study participants treated nationwide with IGF-1 receptor (IGF-1R)-targeted antibodies achieved tumor…”
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Immunomodulatory properties of stem cells and bioactive molecules for tissue engineering by Molina, Eric R., Smith, Brandon T., Shah, Sarita R., Shin, Heungsoo, Mikos, Antonios G.

“…The immune system plays a crucial role in the success of tissue engineering strategies. Failure to consider the interactions between implantable scaffolds,…”
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Mechanically tunable coaxial electrospun models of YAP/TAZ mechanoresponse and IGF-1R activation in osteosarcoma by Molina, Eric R., Chim, Letitia K., Salazar, Maria C., Mehta, Shail M., Menegaz, Brian A., Lamhamedi-Cherradi, Salah-Eddine, Satish, Tejus, Mohiuddin, Sana, McCall, David, Zaske, Ana Maria, Cuglievan, Branko, Lazar, Alexander J., Scott, David W., Grande-Allen, Jane K., Ludwig, Joseph A., Mikos, Antonios G.

“…Current in vitro methods for assessing cancer biology and therapeutic response rely heavily on monolayer cell culture on hard, plastic surfaces that do not…”
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Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma by Lamhamedi-Cherradi, Salah-Eddine, Mohiuddin, Sana, Mishra, Dhruva K., Krishnan, Sandhya, Velasco, Alejandra Ruiz, Vetter, Amelia M., Pence, Kristi, McCall, David, Truong, Danh D., Cuglievan, Branko, Menegaz, Brian A., Utama, Budi, Daw, Najat C., Molina, Eric R., Zielinski, Rafal J., Livingston, John A., Gorlick, Richard, Mikos, Antonios G., Kim, Min P., Ludwig, Joseph A.

“…Osteosarcoma (OS) is a molecularly heterogeneous, aggressive, poorly differentiated pediatric bone cancer that frequently spreads to the lung. Relatively…”
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Effects of Local Antibiotic Delivery from Porous Space Maintainers on Infection Clearance and Induction of an Osteogenic Membrane in an Infected Bone Defect by Shah, Sarita R, Smith, Brandon T, Tatara, Alexander M, Molina, Eric R, Lee, Esther J, Piepergerdes, Trenton C, Uhrig, Brent A, Guldberg, Robert E, Bennett, George N, Wenke, Joseph C, Mikos, Antonios G

“…Reconstruction of large bone defects can be complicated by the presence of both infection and local antibiotic administration. This can be addressed through a…”
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Modeling Stroma-Induced Drug Resistance in a Tissue-Engineered Tumor Model of Ewing Sarcoma by Santoro, Marco, Menegaz, Brian A, Lamhamedi-Cherradi, Salah-Eddine, Molina, Eric R, Wu, Danielle, Priebe, Waldemar, Ludwig, Joseph A, Mikos, Antonios G

“…Three-dimensional (3D) tumor models are gaining traction in the research community given their capacity to mimic aspects of the tumor microenvironment absent…”
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Correlation of nuclear pIGF-1R/IGF-1R and YAP/TAZ in a tissue microarray with outcomes in osteosarcoma patients by Molina, Eric R, Chim, Letitia K, Lamhamedi-Cherradi, Salah-Eddine, Mohiuddin, Sana, McCall, David, Cuglievan, Branko, Krishnan, Sandhya, Porter, Robert W, Ingram, Davis R, Wang, Wei-Lien, Lazar, Alexander J, Scott, David W, Truong, Danh D, Daw, Najat C, Ludwig, Joseph A, Mikos, Antonios G

“…Osteosarcoma (OS) is a genetically diverse bone cancer that lacks a consistent targetable mutation. Recent studies suggest the IGF/PI3K/mTOR pathway and…”
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3D Tissue-Engineered Tumor Model for Ewing’s Sarcoma That Incorporates Bone-like ECM and Mineralization by Molina, Eric R, Chim, Letitia K, Salazar, Maria C, Koons, Gerry L, Menegaz, Brian A, Ruiz-Velasco, Alejandra, Lamhamedi-Cherradi, Salah-Eddine, Vetter, Amelia M, Satish, Tejus, Cuglievan, Branko, Smoak, Mollie M, Scott, David W, Ludwig, Joseph A, Mikos, Antonios G

“…The tumor microenvironment harbors essential components required for cancer progression including biochemical signals and mechanical cues. To study the effects…”
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Effects of Shear Stress Gradients on Ewing Sarcoma Cells Using 3D Printed Scaffolds and Flow Perfusion by Trachtenberg, Jordan E, Santoro, Marco, Williams, Cortes, Piard, Charlotte M, Smith, Brandon T, Placone, Jesse K, Menegaz, Brian A, Molina, Eric R, Lamhamedi-Cherradi, Salah-Eddine, Ludwig, Joseph A, Sikavitsas, Vassilios I, Fisher, John P, Mikos, Antonios G

“…In this work, we combined three-dimensional (3D) scaffolds with flow perfusion bioreactors to evaluate the gradient effects of scaffold architecture and…”
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Abstract B44: Role of EMT transcription factors in the metastatic potential of osteosarcoma by Mohiuddin, Sana, Lamhamedi-Cherradi, Salah-Eddine, Mishra, Dhruva K., Pence, Kristi, Krishnan, Sandhya, Mnegaz, Brian A., Velasco, Alejandra Ruiz, Troung, Danh Dinh, Cuglievan, Branko, Vetter, Amelia, Molina, Eric R., Kim, Min P., Ludwig, Joseph A.

“…Objective: The main culprit for mortality in osteosarcoma (OS) is metastatic pulmonary disease, which originates from a highly selected group of tumor cells…”
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Abstract LB-028: Mechanically tunable 3D microenvironments modulate tumor cell phenotype: Models of mechanotransduction and drug resistance in osteosarcoma by Molina, Eric R., Chim, Letitia K., Salazar, Maria C., Mehta, Shail M., Menegaz, Brian A., Cherradi-Lamhamedi, Salah-Eddine, Satish, Tejus, McCall, David, Mohiuddin, Sana, Zaska, Ana Maria, Grande-Allen, Katherine Jane, Ludwig, Joseph A., Mikos, Antonios G.

“…The past few decades have seen marked improvements in survival rates of osteosarcoma due to the advent of modern chemotherapy, radiotherapy, and surgical…”
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Tissue-Engineered Tumor Microenvironments for Bone Sarcoma by Molina, Eric R

“…Preclinical methods interrogation of cancer biology and of evaluation of potential therapeutics rely heavily on the use of monolayer, adherent culture on…”
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