Search Results - "Molenkamp, Barbara G."

Local Administration of PF-3512676 CpG-B Instigates Tumor-Specific CD8+ T-Cell Reactivity in Melanoma Patients by Molenkamp, Barbara G, Sluijter, Berbel J R, van Leeuwen, Paul A M, Santegoets, Saskia J A M, Meijer, Sybren, Wijnands, Pepijn G J T B, Haanen, John B A G, van den Eertwegh, Alfons J M, Scheper, Rik J, de Gruijl, Tanja D

“…Purpose: Impaired immune effector functions in the melanoma sentinel lymph node (SLN) may allow for early metastatic events. Local administration of PF-3512676…”
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T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment by Koster, Bas D, López González, Marta, van den Hout, Mari FCM, Turksma, Annelies W, Sluijter, Berbel JR, Molenkamp, Barbara G, van Leeuwen, Paul AM, Vosslamber, Saskia, Scheper, Rik J, van den Eertwegh, Alfons JM, van den Tol, M Petrousjka, Jordanova, Ekaterina J, de Gruijl, Tanja D

“…BackgroundWe previously reported CpG-B injection at the primary tumor excision site prior to re-excision and sentinel node biopsy to result in immune…”
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Intradermal CpG-B Activates Both Plasmacytoid and Myeloid Dendritic Cells in the Sentinel Lymph Node of Melanoma Patients by MOLENKAMP, Barbara G, VAN LEEUWEN, Paul A. M, MEIJER, Sybren, SLUIJTER, Berbel J. R, WIJNANDS, Pepijn G. J. T. B, BAARS, Arnold, VAN DEN EERTWEGH, Alfons J. M, SCHEPER, Rik J, DE GRUIJL, Tanja D

“…Purpose: A decrease in the frequency and activation state of dendritic cells in the sentinel lymph node (SLN) has been observed in early stages of melanoma…”
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Arming the Melanoma Sentinel Lymph Node through Local Administration of CpG-B and GM-CSF: Recruitment and Activation of BDCA3/CD141(+) Dendritic Cells and Enhanced Cross-Presentation by Sluijter, Berbel J R, van den Hout, Mari F C M, Koster, Bas D, van Leeuwen, Paul A M, Schneiders, Famke L, van de Ven, Rieneke, Molenkamp, Barbara G, Vosslamber, Saskia, Verweij, Cornelis L, van den Tol, M Petrousjka, van den Eertwegh, Alfons J M, Scheper, Rik J, de Gruijl, Tanja D

“…Melanoma-induced suppression of dendritic cells (DC) in the sentinel lymph node (SLN) interferes with the generation of protective antitumor immunity. In an…”
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In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma by Koster, Bas D., de Jong, Tamarah D., van den Hout, Mari F. C. M., Sluijter, Berbel J. R., Vuylsteke, Ronald J. C. L. M., Molenkamp, Barbara G., Vosslamber, Saskia, van den Tol, M. Petrousjka, van den Eertwegh, Alfons J. M., de Gruijl, Tanja D.

“…Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we…”
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Local Adjuvant Treatment with Low-Dose CpG-B Offers Durable Protection against Disease Recurrence in Clinical Stage I-II Melanoma: Data from Two Randomized Phase II Trials by Koster, Bas D, van den Hout, Mari F C M, Sluijter, Berbel J R, Molenkamp, Barbara G, Vuylsteke, Ronald J C L M, Baars, Arnold, van Leeuwen, Paul A M, Scheper, Rik J, Petrousjka van den Tol, M, van den Eertwegh, Alfons J M, de Gruijl, Tanja D

“…Although risk of recurrence after surgical removal of clinical stage I-II melanoma is considerable, there is no adjuvant therapy with proven efficacy. Here, we…”
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Tumor-Specific CD8+ T Cell Reactivity in the Sentinel Lymph Node of GM-CSF–Treated Stage I Melanoma Patients is Associated with High Myeloid Dendritic Cell Content by VUYLSTEKE, Ronald J. C. L. M, MOLENKAMP, Barbara G, VAN LEEUWEN, Paul A. M, MEIJER, Sybren, WIJNANDS, Pepijn G. J. T. B, HAANEN, John B. A. G, SCHEPER, Rik J, DE GRUIJL, Tanja D

“…Purpose: Impaired immune functions in the sentinel lymph node (SLN) may facilitate early metastatic events during melanoma development. Local potentiation of…”
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Peripheral blood IFN‐γ‐secreting Vα24+Vβ11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load by Molling, Johan W., Kölgen, Wendy, van der Vliet, Hans J.J., Boomsma, Martijn F., Kruizenga, Hinke, Smorenburg, Carolien H., Molenkamp, Barbara G., Langendijk, Johannes A., Leemans, C. René, von Blomberg, B. Mary E., Scheper, Rik J., van den Eertwegh, Alfons J.M.

“…Natural killer T (NKT) cells are CD1d‐restricted lymphoid cells and are characterized by an invariant T‐cell receptor, which in humans consists of a Vα24 chain…”
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Melanoma Sequentially Suppresses Different DC Subsets in the Sentinel Lymph Node, Affecting Disease Spread and Recurrence by van den Hout, Mari F C M, Koster, Bas D, Sluijter, Berbel J R, Molenkamp, Barbara G, van de Ven, Rieneke, van den Eertwegh, Alfons J M, Scheper, Rik J, van Leeuwen, Paul A M, van den Tol, M Petrousjka, de Gruijl, Tanja D

“…Melanoma exerts immune-suppressive effects to facilitate tumor progression and metastatic spread. We studied these effects on dendritic cell (DC) and T-cell…”
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Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T‐lymphocytes and preserved MHC class I antigen expression by van Houdt, Inge S., Sluijter, Berbel J.R., Moesbergen, Laura M., Vos, Wim M., de Gruijl, Tanja D., Molenkamp, Barbara G., van den Eertwegh, Alfons J.M., Hooijberg, Erik, van Leeuwen, Paul A.M., Meijer, Chris J.L.M., Oudejans, Joost J.

“…In this study we investigated whether the presence of specific populations of tumor infiltrating lymphocytes (TILs) in diagnostic primary melanoma biopsies are…”
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Non-radical diagnostic biopsies do not negatively influence melanoma patient survival by Molenkamp, Barbara G, Sluijter, Berbel J R, Oosterhof, Benny, Meijer, Sybren, van Leeuwen, Paul A M

“…In fair-skinned Caucasian populations both the incidence and mortality rates of cutaneous melanoma have been increasing over the past decades. With adjuvant…”
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Sentinel lymph node tumor load: an independent predictor of additional lymph node involvement and survival in melanoma by Vuylsteke, Ronald J C L M, Borgstein, Paul J, van Leeuwen, Paul A M, Gietema, Hester A, Molenkamp, Barbara G, Statius Muller, Markwin G, van Diest, Paul J, van der Sijp, Joost R M, Meijer, Sybren

“…Even though 60% to 80% of melanoma patients with a positive sentinel lymph node (SLN) have no positive additional lymph nodes (ALNs), all these patients are…”
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Local administration of granulocyte/macrophage colony-stimulating factor increases the number and activation state of dendritic cells in the sentinel lymph node of early-stage melanoma by VUYLSTEKE, Ronald J. C. L. M, MOLENKAMP, Barbara G, GIETEMA, Hester A, VAN LEEUWEN, Paul A. M, WIJNANDS, Pepijn G. J. T. B, VOS, Wim, VAN DIEST, Paul J, SCHEPER, Rik J, MEIJER, Sybren, DE GRUIJL, Tanja D

“…The initial tumor-draining lymph node, the sentinel lymph node, not only constitutes the first expected site of micrometastasis but also the first point of…”
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Matched Skin and Sentinel Lymph Node Samples of Melanoma Patients Reveal Exclusive Migration of Mature Dendritic Cells by Molenkamp, Barbara G., Vuylsteke, Ronald J.C.L.M., van Leeuwen, Paul A.M., Meijer, Sybren, Vos, Wim, Wijnands, Pepijn G.J.T.B., Scheper, Rik J., de Gruijl, Tanja D.

“…Mature and immature myeloid dendritic cells (DCs) are thought to differentially modulate T-cell responses in secondary lymphoid tissues. Although mature DCs…”
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Immunomodulation of the melanoma sentinel lymph node: A novel adjuvant therapeutic option by Molenkamp, Barbara G., van Leeuwen, Paul A.M., van den Eertwegh, Alfons J.M., Sluijter, Berbel J.R., Scheper, Rik J., Meijer, Sybren, de Gruijl, Tanja D.

“…Cutaneous melanoma is the most aggressive type of skin cancer. Paradoxically, melanoma is also the most immunogenic tumour identified to date: tumour-reactive…”
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Abstract 4692: Local adjuvant treatment of clinical stage I-II melanoma with low dose CpG-B and/or GM-CSF: Long-term follow-up of three randomized controlled phase II trials by Koster, Bas D., Hout, Mari F. van den, Sluijter, Berbel J., Molenkamp, Barbara G., Vuylsteke, Ronald J., Baars, Arnold, Leeuwen, Paul A. van, Scheper, Rik J., Tol, Monique P. van den, Eertwegh, Alfons J. van den, Gruijl, Tanja D. de

“…Abstract Introduction: Currently, there is no widely used adjuvant treatment available to improve survival after surgical excision of localized melanoma. Here,…”
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Adjuvant treatment of early-stage melanoma by local i.d. administration of low-dose CpG-B and GM-CSF increases recurrence-free survival: long-term follow-up of three randomized clinical trials by de Gruijl, Tanja D, Koster, Bas D, van den Hout, Mari FCM, Sluijter, Berbel JR, Molenkamp, Barbara G, Vuylsteke, Ronald JCLM, van Leeuwen, Paul AM, Scheper, Rik J, van den Tol, Petrousjka, van den Eertwegh, Alfons

“…Currently, there is no adjuvant treatment available that has been shown to reduce the chances of recurrence after surgical excision of localized melanoma…”
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Pre-operative intradermal administration of CpG-B ± GM-CSF in stage I-III melanoma patients arms the sentinel lymph node: evidence for reduced tumor spread by van den Hout, Mari F, Koster, Bas D, Scheper, Rik J, van de Ven, Rieneke, Sluijter, Berbel J, Molenkamp, Barbara G, van den Eertwegh, Alfons J, van Leeuwen, Paul A, van den Tol, Petrousjka M, de Gruijl, Tanja D

“…Melanoma cutis is virtually incurable when it has metastasized to distant organs. Unfortunately, there is no safe and effective adjuvant treatment available…”
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Peripheral blood IFN-gamma-secreting Valpha24+Vbeta11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load by Molling, Johan W, Kölgen, Wendy, van der Vliet, Hans J J, Boomsma, Martijn F, Kruizenga, Hinke, Smorenburg, Carolien H, Molenkamp, Barbara G, Langendijk, Johannes A, Leemans, C René, von Blomberg, B Mary E, Scheper, Rik J, van den Eertwegh, Alfons J M

“…Natural killer T (NKT) cells are CD1d-restricted lymphoid cells and are characterized by an invariant T-cell receptor, which in humans consists of a Valpha24…”
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Peripheral blood IFN- gamma -secreting V alpha 24 super(+)V beta 11 super(+) NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load by Molling, Johan W, Koelgen, Wendy, Van der Vliet, Hans JJ, Boomsma, Martijn F, Kruizenga, Hinke, Smorenburg, Carolien H, Molenkamp, Barbara G, Langendijk, Johannes A, Leemans, CRene, Von Blomberg, BMary E, Scheper, Rik J, Van den Eertwegh, Alfons JM

“…Natural killer T (NKT) cells are CD1d-restricted lymphoid cells and are characterized by an invariant T-cell receptor, which in humans consists of a V alpha 24…”
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