Search Results - "Molekuliarnaia biologiia"

Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches by Zhilnikova, M V, Troitskaya, O S, Novak, D D, Atamanov, V V, Koval, O A

“…Uveal melanoma (UM) is a neuroectodermal tumor that results from malignant transformation of melanocytes in the eye uvea, including the iris, the ciliary body,…”
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The Expression of TP53TG1, LINC00342, MALAT1, H19, and MEG3 Long Noncoding RNAs in Type 2 diabetes mellitus by Kochetova, O V, Avzaletdinova, D Sh, Korytina, G F

“…Type 2 diabetes is a complex and multifactorial metabolic disorder. The frequency of type 2 diabetes has dramatically increased worldwide. Long noncoding RNAs…”
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Cytotoxicity Studies of 5-Arylaminouracil Derivatives by Kezin, V A, Matyugina, E S, Surzhikov, S A, Novikov, M S, Maslova, A A, Karpenko, I L, Ivanov, A V, Kochetkov, S N, Khandazhinskaya, A L

“…We have previously shown that 5-arylaminouracil derivatives can inhibit HIV-1, herpesviruses, mycobacteria, and other pathogens through various mechanisms. The…”
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Bipolar Action of Inhibitor of Vasculogenic Mimicry on Gene Expression in Melanoma Cells by Tchurikov, N A, Vartanian, A A, Klushevskaya, E S, Alembekov, I R, Kretova, A N, Chechetkin, V R, Kravatskaya, G I, Kosorukov, V S, Kravatsky, Y V

“…Multiple exogenous or endogenous factors alter gene expression patterns by different mechanisms that are poorly understood. We used RNA-Seq analysis in order…”
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Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis by Lebedeva, E I, Shchastniy, A T, Babenka, A S, Zinovkin, D A

“…Current data on the molecular mechanisms of liver fibrosis and cirrhosis fail to fully explain all stages of their development. Interactions between individual…”
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Photochemical Processes of Cell DNA Damage by UV Radiation of Various Wavelengths: Biological Consequences by Fraikin, G Ya, Belenikina, N S, Rubin, A B

“…Photochemical reactions in cell DNA are induced in various organisms by solar UV radiation and may lead to a series of biological responses to DNA damage,…”
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Metabolic Heterogeneity of Tumors by Shirmanova, M V, Sinyushkina, S D, Komarova, A D

“…Currently, much attention in oncology is devoted to the issues of tumor heterogeneity, which creates serious problems in the diagnosis and therapy of malignant…”
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Effect of Usnic Acid-Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Used as Monotherapy or in Combination with Olaparib on Transplanted Tumors In Vivo by Kornienko, T E, Zakharenko, A L, Ilina, E S, Chepanova, A A, Zakharova, O D, Dyrkheeva, N S, Popova, N A, Nikolin, V P, Filimonov, A S, Luzina, O A, Salakhutdinov, N F, Lavrik, O I

“…Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that removes various adducts from the 3' end of DNA. Such adducts are formed by enzymes that…”
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Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration by Sherbakov, D V, Arefieva, A B, Komleva, P D, Iz'urov, A E, Khotskin, N V, Bazovkina, D V, Kulikov, A V

“…Tryptophan hydroxylases 1 and 2 (TPH1 and TPH2) play a key role in the synthesis of serotonin (5-HT), a hormone and neurotransmitter, in the peripheral organs…”
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Changes in Expression of Genes Associated with Calcium Processes in the Hippocampus in Mice Exposed to Chronic Social Stress by Pavlova, M B, Smagin, D A, Kudryavtseva, N N, Dyuzhnikova, N A

“…Whole-transcriptome data were used to study the changes in expression of genes coding proteins involved in the calcium regulation processes in the hippocampus…”
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Landscape of KRAS, BRAF, and PIK3CA Mutations and Clinical Features of EBV-Associated and Microsatellite Unstable Gastric Cancer by Danishevich, A M, Pospehova, N I, Stroganova, A M, Golovina, D A, Nikulin, M P, Kalinin, A E, Nikolaev, S E, Stilidi, I S, Lyubchenko, L N

“…Personalization of gastric cancer (GC) treatment is an urgent problem because of the clinical heterogeneity and aggressive course of the disease. Four GC…”
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APPswe/PS1dE9/Blg Transgenic Mouse Line for Modeling Cerebral Amyloid Angiopathy Associated with Alzheimer's Disease by Lysikova, E A, Kuzubova, E V, Radchenko, A I, Patrakhanov, E A, Chaprov, K D, Korokin, M V, Deykin, A V, Gudyrev, O S, Pokrovskii, M V

“…Alzheimer's disease (AD) is the most common proteinopathy, which is accompanied by a steady decrease in the patient's cognitive functions with a simultaneous…”
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Modern Approaches to Protein Engineering to Create Enzymes with New Catalytic Properties by Tyugashev, T E, Fedorova, O S, Kuznetsov, N A

“…Adenine-DNA-glycosylase MutY is a monofunctional enzyme and catalyzes hydrolysis of N-glycosidic bonds with adenine residues located opposite 8-oxonuanine…”
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Mechanisms of the Specificity of the CRISPR/Cas9 System in Genome Editing by Kulishova, L M, Vokhtantsev, I P, Kim, D V, Zharkov, D O

“…The CRISPR/Cas9 system, which was discovered recently, utilizes nucleases targeted by sequence complementarity and is originally intended to protect bacteria…”
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Poly(ADP-Ribose) Polymerases 1 and 2: Classical Functions and Interaction with New Histone Poly(ADP-Ribosyl)ation Factor HPF1 by Kurgina, T A, Lavrik, O I

“…Poly(ADP-ribose) (PAR) is a negatively charged polymer, linear or branched, that consists of ADP-ribose monomers. PAR is synthesized by…”
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New Zwitter-Ionic Oligonucleotides: Preparation and Complementary Binding by Patrushev, D E, Burakova, E A, Bizyaev, S N, Fokina, A A, Stetsenko, D A

“…New zwitter-ionic oligonucleotide derivatives containing 1,2,3,4-tetrahydroisoquinoline-7-sulfonyl phosphoramidate group are described. Automated synthesis of…”
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Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma by Khlebodarova, T M, Demenkov, P S, Ivanisenko, T V, Antropova, E A, Lavrik, I N, Ivanisenko, V A

“…One of the most common malignant liver diseases is hepatocellular carcinoma, which has a high recurrence rate and a low five-year survival rate. It is very…”
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On Immunological Studies at Sirius University of Science and Technology by Astrakhantseva, I V, Krut', V G, Chuvpilo, S A, Shevyrev, D V, Shumeev, A N, Rybtsov, S A, Nedospasov, S A

“…This short report summarizes the results of recent immunological studies performed at the new Sirius University of Science and Technology. The report focuses…”
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Genotype-Specific Features of Cold-Induced Sweetening Process Regulation in Potato Varieties Nikulinsky, Symfonia, and Nevsky by Egorova, A A, Saboiev, I A, Kostina, N E, Kuvaeva, D D, Shcherban, A B, Ibragimova, S M, Salina, E A, Kochetov, A V

“…In this study, we performed expression analysis of genes associated with cold-induced sweetening in potato tubers: vacuolar invertase (Pain-1), sucrose…”
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Comparative Analysis of Family A DNA-Polymerases as a Searching Tool for Enzymes with New Properties by Bulygin, A A, Kuznetsova, A A, Fedorva, O S, Kuznetsov, N A

“…DNA polymerases catalyze DNA synthesis during DNA replication, repair, and recombination. A number of DNA polymerases, such as the Taq enzyme from Thermus…”
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