Search Results - "Molecular therapy. Nucleic acids"

lnc-3215 Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway by Yang, Jie, Gong, Yafan, Cai, Jingzeng, Liu, Qi, Zhang, Ziwei

“…Selenium deficiency has been proven to induce calcium disorders in the chicken heart. However, detailed regulatory mechanisms, e.g., the long noncoding RNA…”
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Circular RNAs in Cancer by Bach, Duc-Hiep, Lee, Sang Kook, Sood, Anil K.

“…Circular RNAs (circRNAs) are a class of single-stranded closed RNA molecules that are formed by precursor mRNA back-splicing or skipping events of thousands of…”
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Characterization of the Immune Cell Infiltration Landscape in Head and Neck Squamous Cell Carcinoma to Aid Immunotherapy by Zhang, Xinhai, Shi, Mengqi, Chen, Tielou, Zhang, Boxin

“…The tumor microenvironment (TME) chiefly consists of tumor cells and tumor-infiltrating immune cells admixed with the stromal component. A recent clinical…”
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Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia by Yang, Jialei, Zhang, Xiufen, Chen, Xiangjie, Wang, Lei, Yang, Guodong

“…The intrinsic ability of neurogenesis after stroke has been proven weak, which results in insufficient repair of injury in the nerve system. Recent studies…”
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siRNA Versus miRNA as Therapeutics for Gene Silencing by Lam, Jenny K W, Chow, Michael Y T, Zhang, Yu, Leung, Susan W S

“…Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs (miRNAs) are noncoding RNAs with important roles in gene regulation…”
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Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines by Hassett, Kimberly J., Benenato, Kerry E., Jacquinet, Eric, Lee, Aisha, Woods, Angela, Yuzhakov, Olga, Himansu, Sunny, Deterling, Jessica, Geilich, Benjamin M., Ketova, Tatiana, Mihai, Cosmin, Lynn, Andy, McFadyen, Iain, Moore, Melissa J., Senn, Joseph J., Stanton, Matthew G., Almarsson, Örn, Ciaramella, Giuseppe, Brito, Luis A.

“…mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and…”
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Immune-Related lncRNA to Construct Novel Signature and Predict the Immune Landscape of Human Hepatocellular Carcinoma by Hong, Weifeng, Liang, Li, Gu, Yujun, Qi, Zhenhua, Qiu, Haibo, Yang, Xiaosong, Zeng, Weian, Ma, Liheng, Xie, Jingdun

“…The signature composed of immune-related long noncoding ribonucleic acids (irlncRNAs) with no requirement of specific expression level seems to be valuable in…”
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Comprehensive Analysis of the PD-L1 and Immune Infiltrates of m6A RNA Methylation Regulators in Head and Neck Squamous Cell Carcinoma by Yi, Lilan, Wu, Guowu, Guo, Longhua, Zou, Xiaofang, Huang, Ping

“…Because most studies have focused on the intrinsic carcinogenic pathways of tumors, the underlying role of N6-methyladenosine (m6A) methylation in tumor immune…”
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The Promising Role of miR-21 as a Cancer Biomarker and Its Importance in RNA-Based Therapeutics by Bautista-Sánchez, Diana, Arriaga-Canon, Cristian, Pedroza-Torres, Abraham, De La Rosa-Velázquez, Inti Alberto, González-Barrios, Rodrigo, Contreras-Espinosa, Laura, Montiel-Manríquez, Rogelio, Castro-Hernández, Clementina, Fragoso-Ontiveros, Verónica, Álvarez-Gómez, Rosa María, Herrera, Luis A.

“…MicroRNAs are small noncoding transcripts that posttranscriptionally regulate gene expression via base-pairing complementarity. Their role in cancer can be…”
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Circular RNA Cdr1as Upregulates SCAI to Suppress Cisplatin Resistance in Ovarian Cancer via miR-1270 Suppression by Zhao, Zhao, Ji, Mei, Wang, Qianqing, He, Nannan, Li, Yue

“…The aim of this study is to explore the roles of circular RNA (circRNA) Cdr1as on cisplatin resistance in ovarian cancer and explore the underlying mechanisms…”
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Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine by Chakraborty, Chiranjib, Sharma, Ashish Ranjan, Sharma, Garima, Doss, C. George Priya, Lee, Sang-Soo

“…In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are some of the most important biopharmaceuticals that are in commercial…”
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ALKBH5 Inhibited Cell Proliferation and Sensitized Bladder Cancer Cells to Cisplatin by m6A-CK2α-Mediated Glycolysis by Yu, Hao, Yang, Xiao, Tang, Jinyuan, Si, Shuhui, Zhou, Zijian, Lu, Jiancheng, Han, Jie, Yuan, Baorui, Wu, Qikai, Lu, Qiang, Yang, Haiwei

“…N6-methyladenosine (m6A) is the most commonly occurring internal RNA modification to be found in eukaryotic mRNA and serves an important role in various…”
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Deep-AmPEP30: Improve Short Antimicrobial Peptides Prediction with Deep Learning by Yan, Jielu, Bhadra, Pratiti, Li, Ang, Sethiya, Pooja, Qin, Longguang, Tai, Hio Kuan, Wong, Koon Ho, Siu, Shirley W.I.

“…Antimicrobial peptides (AMPs) are a valuable source of antimicrobial agents and a potential solution to the multi-drug resistance problem. In particular,…”
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iRNA-PseColl: Identifying the Occurrence Sites of Different RNA Modifications by Incorporating Collective Effects of Nucleotides into PseKNC by Feng, Pengmian, Ding, Hui, Yang, Hui, Chen, Wei, Lin, Hao, Chou, Kuo-Chen

“…There are many different types of RNA modifications, which are essential for numerous biological processes. Knowledge about the occurrence sites of RNA…”
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The MSC-Derived Exosomal lncRNA H19 Promotes Wound Healing in Diabetic Foot Ulcers by Upregulating PTEN via MicroRNA-152-3p by Li, Bo, Luan, Song, Chen, Jing, Zhou, Yue, Wang, Tingting, Li, Zhijuan, Fu, Yili, Zhai, Aixia, Bi, Changlong

“…Mesenchymal stem cells (MSCs) have been reported to hold promise to accelerate the wound-healing process in diabetic foot ulcer (DFU) due to the multilineage…”
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Non-coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis by Hashemian, Seyed MohammadReza, Pourhanifeh, Mohammad Hossein, Fadaei, Sara, Velayati, Ali Akbar, Mirzaei, Hamed, Hamblin, Michael R.

“…Sepsis is characterized as an uncontrolled host response to infection, and it represents a serious health challenge, causing excess mortality and morbidity…”
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A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA by Baiersdörfer, Markus, Boros, Gábor, Muramatsu, Hiromi, Mahiny, Azita, Vlatkovic, Irena, Sahin, Ugur, Karikó, Katalin

“…The increasing importance of in vitro-transcribed (IVT) mRNA for synthesizing the encoded therapeutic protein in vivo demands the manufacturing of pure mRNA…”
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Off-target Effects in CRISPR/Cas9-mediated Genome Engineering by Zhang, Xiao-Hui, Tee, Louis Y, Wang, Xiao-Gang, Huang, Qun-Shan, Yang, Shi-Hua

“…CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified…”
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SERCA Overexpression Improves Mitochondrial Quality Control and Attenuates Cardiac Microvascular Ischemia-Reperfusion Injury by Tan, Ying, Mui, David, Toan, Sam, Zhu, Pingjun, Li, Ruibing, Zhou, Hao

“…Despite significant advances in the treatment of myocardial ischemia-reperfusion (I/R) injury, coronary circulation is a so far neglected target of…”
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