Search Results - "Molecular psychiatry"

Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies by Solmi, Marco, Radua, Joaquim, Olivola, Miriam, Croce, Enrico, Soardo, Livia, Salazar de Pablo, Gonzalo, Il Shin, Jae, Kirkbride, James B., Jones, Peter, Kim, Jae Han, Kim, Jong Yeob, Carvalho, Andrè F., Seeman, Mary V., Correll, Christoph U., Fusar-Poli, Paolo

“…Promotion of good mental health, prevention, and early intervention before/at the onset of mental disorders improve outcomes. However, the range and peak ages…”
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The serotonin theory of depression: a systematic umbrella review of the evidence by Moncrieff, Joanna, Cooper, Ruth E., Stockmann, Tom, Amendola, Simone, Hengartner, Michael P., Horowitz, Mark A.

“…The serotonin hypothesis of depression is still influential. We aimed to synthesise and evaluate evidence on whether depression is associated with lowered…”
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The Amyloid-β Pathway in Alzheimer’s Disease by Hampel, Harald, Hardy, John, Blennow, Kaj, Chen, Christopher, Perry, George, Kim, Seung Hyun, Villemagne, Victor L., Aisen, Paul, Vendruscolo, Michele, Iwatsubo, Takeshi, Masters, Colin L., Cho, Min, Lannfelt, Lars, Cummings, Jeffrey L., Vergallo, Andrea

“…Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology. While the detailed…”
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COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States by Wang, Quan Qiu, Kaelber, David C., Xu, Rong, Volkow, Nora D.

“…The global pandemic of COVID-19 is colliding with the epidemic of opioid use disorders (OUD) and other substance use disorders (SUD) in the United States (US)…”
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Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies by Wang, Yun-He, Li, Jin-Qiao, Shi, Ju-Fang, Que, Jian-Yu, Liu, Jia-Jia, Lappin, Julia M., Leung, Janni, Ravindran, Arun V., Chen, Wan-Qing, Qiao, You-Lin, Shi, Jie, Lu, Lin, Bao, Yan-Ping

“…The link between depression and anxiety status and cancer outcomes has been well-documented but remains unclear. We comprehensively quantified the association…”
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Genetics of attention deficit hyperactivity disorder by Faraone, Stephen V., Larsson, Henrik

“…Decades of research show that genes play an vital role in the etiology of attention deficit hyperactivity disorder (ADHD) and its comorbidity with other…”
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Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders by Sohal, Vikaas S., Rubenstein, John L. R.

“…In 2003 Rubenstein and Merzenich hypothesized that some forms of Autism (ASD) might be caused by a reduction in signal-to-noise in key neural circuits, which…”
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Diet and depression: exploring the biological mechanisms of action by Marx, Wolfgang, Lane, Melissa, Hockey, Meghan, Aslam, Hajara, Berk, Michael, Walder, Ken, Borsini, Alessandra, Firth, Joseph, Pariante, Carmine M., Berding, Kirsten, Cryan, John F., Clarke, Gerard, Craig, Jeffrey M., Su, Kuan-Pin, Mischoulon, David, Gomez-Pinilla, Fernando, Foster, Jane A., Cani, Patrice D., Thuret, Sandrine, Staudacher, Heidi M., Sánchez-Villegas, Almudena, Arshad, Husnain, Akbaraly, Tasnime, O’Neil, Adrienne, Segasby, Toby, Jacka, Felice N.

“…The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and…”
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The kynurenine pathway: a finger in every pie by Savitz, Jonathan

“…The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of nicotinamide adenine dinucleotide (NAD+). Because energy…”
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Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies by Lassale, Camille, Batty, G. David, Baghdadli, Amaria, Jacka, Felice, Sánchez-Villegas, Almudena, Kivimäki, Mika, Akbaraly, Tasnime

“…With depression being the psychiatric disorder incurring the largest societal costs in developed countries, there is a need to gather evidence on the role of…”
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The blood-brain barrier in aging and neurodegeneration by Knox, Emily G., Aburto, Maria R., Clarke, Gerard, Cryan, John F., O’Driscoll, Caitriona M.

“…The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange of compounds between the blood and the…”
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Mechanisms of ketamine action as an antidepressant by Zanos, P, Gould, T D

“…Clinical studies have demonstrated that a single sub-anesthetic dose of the dissociative anesthetic ketamine induces rapid and sustained antidepressant…”
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Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model by Price, Rebecca B., Duman, Ronald

“…Chronic stress and depressive-like behaviors in basic neuroscience research have been associated with impairments of neuroplasticity, such as neuronal atrophy…”
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A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia by McGuinness, A. J., Davis, J. A., Dawson, S. L., Loughman, A., Collier, F., O’Hely, M., Simpson, C. A., Green, J., Marx, W., Hair, C., Guest, G., Mohebbi, M., Berk, M., Stupart, D., Watters, D., Jacka, F. N.

“…The emerging understanding of gut microbiota as ‘metabolic machinery’ influencing many aspects of physiology has gained substantial attention in the field of…”
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Depression and obesity: evidence of shared biological mechanisms by Milaneschi, Yuri, Simmons, W. Kyle, van Rossum, Elisabeth F. C., Penninx, Brenda WJH

“…Depression and obesity are common conditions with major public health implications that tend to co-occur within individuals. The relationship between these…”
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A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression by Goldsmith, D R, Rapaport, M H, Miller, B J

“…Schizophrenia, bipolar disorder and major depressive disorder (MDD) have all been associated with aberrant blood cytokine levels; however, neither the pattern…”
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Tau PET imaging in neurodegenerative tauopathies—still a challenge by Leuzy, Antoine, Chiotis, Konstantinos, Lemoine, Laetitia, Gillberg, Per-Göran, Almkvist, Ove, Rodriguez-Vieitez, Elena, Nordberg, Agneta

“…The accumulation of pathological misfolded tau is a feature common to a collective of neurodegenerative disorders known as tauopathies, of which Alzheimer’s…”
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Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD) by Fava, Maurizio, Freeman, Marlene P., Flynn, Martina, Judge, Heidi, Hoeppner, Bettina B., Cusin, Cristina, Ionescu, Dawn F., Mathew, Sanjay J., Chang, Lee C., Iosifescu, Dan V., Murrough, James, Debattista, Charles, Schatzberg, Alan F., Trivedi, Madhukar H., Jha, Manish K, Sanacora, Gerard, Wilkinson, Samuel T., Papakostas, George I.

“…Numerous placebo-controlled studies have demonstrated the ability of ketamine, an NMDA receptor antagonist, to induce rapid (within hours), transient…”
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Microglial regional heterogeneity and its role in the brain by Tan, Yun-Long, Yuan, Yi, Tian, Li

“…Microglia have been recently shown to manifest a very interesting phenotypical heterogeneity across different regions in the mammalian central nervous system…”
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Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group by Schmaal, L, Hibar, D P, Sämann, P G, Hall, G B, Baune, B T, Jahanshad, N, Cheung, J W, van Erp, T G M, Bos, D, Ikram, M A, Vernooij, M W, Niessen, W J, Tiemeier, H, Hofman, A, Wittfeld, K, Grabe, H J, Janowitz, D, Bülow, R, Selonke, M, Völzke, H, Grotegerd, D, Dannlowski, U, Arolt, V, Opel, N, Heindel, W, Kugel, H, Hoehn, D, Czisch, M, Couvy-Duchesne, B, Rentería, M E, Strike, L T, Wright, M J, Mills, N T, de Zubicaray, G I, McMahon, K L, Medland, S E, Martin, N G, Gillespie, N A, Goya-Maldonado, R, Gruber, O, Krämer, B, Hatton, S N, Lagopoulos, J, Hickie, I B, Frodl, T, Carballedo, A, Frey, E M, van Velzen, L S, Penninx, B W J H, van Tol, M-J, van der Wee, N J, Davey, C G, Harrison, B J, Mwangi, B, Cao, B, Soares, J C, Veer, I M, Walter, H, Schoepf, D, Zurowski, B, Konrad, C, Schramm, E, Normann, C, Schnell, K, Sacchet, M D, Gotlib, I H, MacQueen, G M, Godlewska, B R, Nickson, T, McIntosh, A M, Papmeyer, M, Whalley, H C, Hall, J, Sussmann, J E, Li, M, Walter, M, Aftanas, L, Brack, I, Bokhan, N A, Thompson, P M, Veltman, D J

“…The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades…”
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