Search Results - "Molecular neurobiology"

Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation by Lima Giacobbo, Bruno, Doorduin, Janine, Klein, Hans C., Dierckx, Rudi A. J. O., Bromberg, Elke, de Vries, Erik F. J.

“…Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and diseased brain. As a result, there is a large body of…”
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Ferroptosis and Its Role in Diverse Brain Diseases by Weiland, Abigail, Wang, Yamei, Wu, Weihua, Lan, Xi, Han, Xiaoning, Li, Qian, Wang, Jian

“…Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen…”
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Role of the Prefrontal Cortex in Pain Processing by Ong, Wei-Yi, Stohler, Christian S., Herr, Deron R.

“…The prefrontal cortex (PFC) is not only important in executive functions, but also pain processing. The latter is dependent on its connections to other areas…”
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The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review by Sochocka, Marta, Donskow-Łysoniewska, Katarzyna, Diniz, Breno Satler, Kurpas, Donata, Brzozowska, Ewa, Leszek, Jerzy

“…One of the most important scientific discoveries of recent years was the disclosure that the intestinal microflora takes part in bidirectional communication…”
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Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases by Tang, Yu, Le, Weidong

“…One of the most striking hallmarks shared by various neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease (AD), and amyotrophic…”
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Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma by Ahir, Bhavesh K., Engelhard, Herbert H., Lakka, Sajani S.

“…Angiogenesis is the growth of new capillaries from the preexisting blood vessels. Glioblastoma (GBM) tumors are highly vascularized tumors, and glioma growth…”
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Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment by Liu, Shan, Gao, Jiguo, Zhu, Mingqin, Liu, Kangding, Zhang, Hong-Liang

“…Understanding how gut flora influences gut-brain communications has been the subject of significant research over the past decade. The broadening of the term…”
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Systematic Review of miRNA as Biomarkers in Alzheimer’s Disease by Swarbrick, S., Wragg, N., Ghosh, S., Stolzing, Alexandra

“…Currently there are 850,000 people with Alzheimer’s disease in the UK, with an estimated rise to 1.1 million by 2025. Alzheimer’s disease is characterised by…”
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The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease by Monzio Compagnoni, Giacomo, Di Fonzo, Alessio, Corti, Stefania, Comi, Giacomo P., Bresolin, Nereo, Masliah, Eliezer

“…Although the pathogenesis of neurodegenerative diseases is still widely unclear, various mechanisms have been proposed and several pieces of evidence are…”
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Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease by Ali, Tahir, Kim, Taehyun, Rehman, Shafiq Ur, Khan, Muhammad Sohail, Amin, Faiz Ul, Khan, Mehtab, Ikram, Muhammad, Kim, Myeong Ok

“…Well-established studies have shown an elevated level of reactive oxygen species (ROS) that induces oxidative stress in the Alzheimer’s disease (AD) patient’s…”
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Inflammatory Response in the CNS: Friend or Foe? by Sochocka, Marta, Diniz, Breno Satler, Leszek, Jerzy

“…Inflammatory reactions could be both beneficial and detrimental to the brain, depending on strengths of their activation in various stages of…”
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Brain Photobiomodulation Therapy: a Narrative Review by Salehpour, Farzad, Mahmoudi, Javad, Kamari, Farzin, Sadigh-Eteghad, Saeed, Rasta, Seyed Hossein, Hamblin, Michael R

“…Brain photobiomodulation (PBM) therapy using red to near-infrared (NIR) light is an innovative treatment for a wide range of neurological and psychological…”
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Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis by Köhler, Cristiano A., Freitas, Thiago H., Stubbs, Brendon, Maes, Michael, Solmi, Marco, Veronese, Nicola, de Andrade, Nayanna Q., Morris, Gerwyn, Fernandes, Brisa S., Brunoni, André R., Herrmann, Nathan, Raison, Charles L., Miller, Brian J., Lanctôt, Krista L., Carvalho, André F.

“…Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute to the pathophysiology of major depressive disorder (MDD), and…”
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Oxidative Stress in Neurodegenerative Diseases by Niedzielska, Ewa, Smaga, Irena, Gawlik, Maciej, Moniczewski, Andrzej, Stankowicz, Piotr, Pera, Joanna, Filip, Małgorzata

“…The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD), are…”
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Oxidative Stress in Autism Spectrum Disorder by Bjørklund, Geir, Meguid, Nagwa A., El-Bana, Mona A., Tinkov, Alexey A., Saad, Khaled, Dadar, Maryam, Hemimi, Maha, Skalny, Anatoly V., Hosnedlová, Božena, Kizek, Rene, Osredkar, Joško, Urbina, Mauricio A., Fabjan, Teja, El-Houfey, Amira A., Kałużna-Czaplińska, Joanna, Gątarek, Paulina, Chirumbolo, Salvatore

“…According to the United States Centers for Disease Control and Prevention (CDC), as of July 11, 2016, the reported average incidence of children diagnosed with…”
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Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury by Anzell, Anthony R., Maizy, Rita, Przyklenk, Karin, Sanderson, Thomas H.

“…Mitochondria are key regulators of cell fate during disease. They control cell survival via the production of ATP that fuels cellular processes and,…”
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The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders by Czubowicz, Kinga, Jęśko, Henryk, Wencel, Przemysław, Lukiw, Walter J., Strosznajder, Robert P.

“…Bioactive sphingolipids—ceramide, sphingosine, and their respective 1-phosphates (C1P and S1P)—are signaling molecules serving as intracellular second…”
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The ERK Pathway: Molecular Mechanisms and Treatment of Depression by Wang, John Q., Mao, Limin

“…Major depressive disorder is a chronic debilitating mental illness. Its pathophysiology at cellular and molecular levels is incompletely understood. Increasing…”
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Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates by Grolli, Roberta Eduarda, Mingoti, Maiqueli Eduarda Dama, Bertollo, Amanda Gollo, Luzardo, Adriana Remião, Quevedo, João, Réus, Gislaine Zilli, Ignácio, Zuleide Maria

“…Since December 2019, the world has been experiencing the challenge of facing coronavirus disease-19 (COVID-19), a severe infectious disease caused by the new…”
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Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models by Rom, Slava, Zuluaga-Ramirez, Viviana, Gajghate, Sachin, Seliga, Alecia, Winfield, Malika, Heldt, Nathan A., Kolpakov, Mikhail A., Bashkirova, Yulia V., Sabri, Abdel Karim, Persidsky, Yuri

“…End organ injury in diabetes mellitus (DM) is driven by microvascular compromise (including diabetic retinopathy and nephropathy). Cognitive impairment is a…”
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