Search Results - "Molecular immunology"

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells by Zhang, Jiawei, Zheng, Yaling, Luo, Yan, Du, Yu, Zhang, Xiaojie, Fu, Jianliang

“…•Curcumin reversed LPS-induced decrease in BV2 cell viability and morphological changes.•Curcumin promoted microglial polarization from the M1 to the M2…”
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Long non-coding RNA: Classification, biogenesis and functions in blood cells by Dahariya, Swati, Paddibhatla, Indira, Kumar, Santosh, Raghuwanshi, Sanjeev, Pallepati, Adithya, Gutti, Ravi Kumar

“…•lncRNAs contribute towards the hematopoietic stem cell development and lineage selection.•This review summarizes the current status of knowledge on lncRNAs…”
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The role of mitochondria in NLRP3 inflammasome activation by Liu, Qiuyun, Zhang, Danyan, Hu, Diyu, Zhou, Xiangmei, Zhou, Yang

“…•NLRP3 inducers leads to externalization or release of mitochondria-derived molecule, which activate the NLRP3 inflammasome.•Ubiquitination/deubiquitination…”
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The protective effect of dexmedetomidine on LPS-induced acute lung injury through the HMGB1-mediated TLR4/NF-κB and PI3K/Akt/mTOR pathways by Meng, Lu, Li, Longyun, Lu, Shan, Li, Kai, Su, Zhenbo, Wang, Yunyun, Fan, Xiaodi, Li, Xuyang, Zhao, Guoqing

“…•We first argued that DEX could treat LPS-induced ALI in rats via HMGB1 mediation.•We first demonstrated that DEX regulated ALI via HMGB1 mediated TLR4/NF-κB…”
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Alternative molecular formats and therapeutic applications for bispecific antibodies by Spiess, Christoph, Zhai, Qianting, Carter, Paul J.

“…•Bispecific antibodies (BsAb) bind 2 distinct antigens or epitopes on the same antigen.•Antibody domain structure has been exploited to make >60 alternative…”
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Seafood allergy: A comprehensive review of fish and shellfish allergens by Ruethers, Thimo, Taki, Aya C., Johnston, Elecia B., Nugraha, Roni, Le, Thu T.K., Kalic, Tanja, McLean, Thomas R., Kamath, Sandip D., Lopata, Andreas L.

“…•Immunological cross-reactivity between fish and shellfish allergens has not been demonstrated conclusively.•WHO/IUIS registered seafood allergens include…”
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Chemokines and their receptors promoting the recruitment of myeloid-derived suppressor cells into the tumor by Li, Bao-Hua, Garstka, Malgorzata A., Li, Zong-Fang

“…•We describe the chemokines and their receptors, including CCL2/CCL12-CCR2, CCL3/4/5-CCR5, CCL15-CCR1, CX3CL1/CCL26-CX3CR1, CXCL5/2/1-CXCR2, CXCL8-CXCR1/2,…”
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The immunology of the porcine skin and its value as a model for human skin by Summerfield, Artur, Meurens, François, Ricklin, Meret E.

“…•The porcine skin is a highly valuable pre-clinical model with many tools available.•Here we review the immune cells in the pig skin with a focus on dendritic…”
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BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis by Chen, Lu, Lu, Feng-bin, Chen, Da-zhi, Wu, Jin-lu, Hu, En-de, Xu, Lan-man, Zheng, Ming-hua, Li, Hui, Huang, Yu, Jin, Xiao-ya, Gong, Yue-wen, Lin, Zhuo, Wang, Xiao-dong, Chen, Yong-ping

“…•BMSCs-exo attenuated liver damage induced by autoimmune hepatitis.•BMSCs-exo decreased serum levels of ALT, AST and pro-inflammatory cytokines.•BMSCs-exo…”
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A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders by Kamali, Ali N., Noorbakhsh, Seyedeh Masoomeh, Hamedifar, Haleh, Jadidi-Niaragh, Farhad, Yazdani, Reza, Bautista, José M., Azizi, Gholamreza

“…•Evidences for Th17 cells plasticity are reviewed.•Highlights the importance of Th17 cells plasticity in immune diseases.•Th1-like Th17 cells play pivotal role…”
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Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production by Gong, Zizhen, Zhao, Shengnan, Zhou, Jiefei, Yan, Junkai, Wang, Lingyu, Du, Xixi, Li, Hui, Chen, Yingwei, Cai, Wei, Wu, Jin

“…•Curcumin can inhibit DSS-induced NLRP3 inflammasome activation and IL-1β production.•Curcumin reduces DSS-induced K+ efflux, ROS formation and cathepsin B…”
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WHO/IUIS Allergen Nomenclature: Providing a common language by Pomés, Anna, Davies, Janet M., Gadermaier, Gabriele, Hilger, Christiane, Holzhauser, Thomas, Lidholm, Jonas, Lopata, Andreas L., Mueller, Geoffrey A., Nandy, Andreas, Radauer, Christian, Chan, Sanny K., Jappe, Uta, Kleine-Tebbe, Jörg, Thomas, Wayne R., Chapman, Martin D., van Hage, Marianne, van Ree, Ronald, Vieths, Stefan, Raulf, Monika, Goodman, Richard E.

“…•Beginning and evolution of the official Allergen Nomenclature system 1980–2018.•Allergen Names abbreviated genus, species and number.•Expected data including…”
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Insect (food) allergy and allergens by de Gier, Steffie, Verhoeckx, Kitty

“…•Food allergy to insects was described for different insect species.•De novo sensitization (primary allergy) to insects does exist.•Sensitization to edible…”
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Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury by Li, Jianhua, Li, Mengyu, Li, Ling, Ma, Jiamin, Yao, Chengye, Yao, Shanglong

“…•GYY4137 could alleviate septicemia-induced ferroptosis in ALI.•The ferritin and ferritin light chain levels increased after CLP as a compensatory…”
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C1q: A fresh look upon an old molecule by Thielens, Nicole M., Tedesco, Francesco, Bohlson, Suzanne S., Gaboriaud, Christine, Tenner, Andrea J.

“…•Classical and new functions of complement component C1q are reviewed.•Recombinant C1q provides a new tool for structure-function analysis.•C1q…”
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Compendium of current complement therapeutics by Zelek, Wioleta M, Xie, Long, Morgan, B Paul, Harris, Claire L

“…•Complement plays a key role in pathogenesis of inflammatory and autoimmune disease.•Numerous drugs are in clinical development for complement-mediated…”
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Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation by Mai, Chu-Tian, Wu, Mei-Mei, Wang, Chun-Li, Su, Zi-Ren, Cheng, Yuan-Yuan, Zhang, Xiao-Jun

“…[Display omitted] •Palmatine alleviated DSS-induced experimental colitis in mice.•Palmatine suppressed NLRP3 inflammasomes activation in DSS-induce mice and…”
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Dapk1 improves inflammation, oxidative stress and autophagy in LPS-induced acute lung injury via p38MAPK/NF-κB signaling pathway by Li, Tao, Wu, Yi-Na, Wang, Hui, Ma, Jun-Yu, Zhai, Shan-Shan, Duan, Jun

“…•LPS-induced ALI mice had decreased Dapk1 and activated p38MAPK/NF-κB pathway.•No changes were found in p-p38 and nuclear p65 NF-κB in LPS-induced Dapk1-/-…”
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Intracellular complement − the complosome − in immune cell regulation by Arbore, Giuseppina, Kemper, Claudia, Kolev, Martin

“…•Recent, evidence have demonstrated presence of intracellular complement proteins and their activation (the complosome).•The complosome plays a role in basic…”
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Autophagy and inflammasomes by Harris, James, Lang, Tali, Thomas, Jacinta P.W., Sukkar, Maria B., Nabar, Neel R., Kehrl, John H.

“…•Loss of autophagy increases inflammasome activation.•Autophagy removes inflammasome-activating stimuli from the cytosol.•Autophagy degrades inflammasome…”
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