Search Results - "Molecular cell"

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells by Hoffmann, Markus, Kleine-Weber, Hannah, Pöhlmann, Stefan

“…The pandemic coronavirus SARS-CoV-2 threatens public health worldwide. The viral spike protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2…”
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Ferroptosis at the intersection of lipid metabolism and cellular signaling by Liang, Deguang, Minikes, Alexander M., Jiang, Xuejun

“…Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated to play an important role in multiple diseases including cancer,…”
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Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers by Shi, Hailing, Wei, Jiangbo, He, Chuan

“…Cellular RNAs are naturally decorated with a variety of chemical modifications. The structural diversity of the modified nucleosides provides regulatory…”
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Redox metabolism: ROS as specific molecular regulators of cell signaling and function by Lennicke, Claudia, Cochemé, Helena M.

“…Redox reactions are intrinsically linked to energy metabolism. Therefore, redox processes are indispensable for organismal physiology and life itself. The term…”
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Role of Mitochondria in Ferroptosis by Gao, Minghui, Yi, Junmei, Zhu, Jiajun, Minikes, Alexander M, Monian, Prashant, Thompson, Craig B, Jiang, Xuejun

“…Ferroptosis is a regulated necrosis process driven by iron-dependent lipid peroxidation. Although ferroptosis and cellular metabolism interplay with one…”
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The Biogenesis, Functions, and Challenges of Circular RNAs by Li, Xiang, Yang, Li, Chen, Ling-Ling

“…Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally…”
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Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy by Bader, Jackie E., Voss, Kelsey, Rathmell, Jeffrey C.

“…The growing field of immune metabolism has revealed promising indications for metabolic targets to modulate anti-cancer immunity. Combination therapies…”
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Mechanisms Controlling PD-L1 Expression in Cancer by Cha, Jong-Ho, Chan, Li-Chuan, Li, Chia-Wei, Hsu, Jennifer L., Hung, Mien-Chie

“…The engagement of programmed cell death protein 1 (PD-1; encoded by the PDCD1 gene) receptor expressed on activated T cells and its ligand, programmed…”
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The Unfolded Protein Response and Cell Fate Control by Hetz, Claudio, Papa, Feroz R.

“…The secretory capacity of a cell is constantly challenged by physiological demands and pathological perturbations. To adjust and match the protein-folding…”
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Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1 by Yan, Bo, Ai, Youwei, Sun, Qi, Ma, Yan, Cao, Yang, Wang, Jiawen, Zhang, Zhiyuan, Wang, Xiaodong

“…Ferroptosis is a form of necrotic cell death caused by iron-dependent peroxidation of polyunsaturated phospholipids on cell membranes and is actively…”
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Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis by Xiong, Xuelian, Kuang, Henry, Ansari, Sahar, Liu, Tongyu, Gong, Jianke, Wang, Shuai, Zhao, Xu-Yun, Ji, Yewei, Li, Chuan, Guo, Liang, Zhou, Linkang, Chen, Zhimin, Leon-Mimila, Paola, Chung, Meng Ting, Kurabayashi, Katsuo, Opp, Judy, Campos-Pérez, Francisco, Villamil-Ramírez, Hugo, Canizales-Quinteros, Samuel, Lyons, Robert, Lumeng, Carey N., Zhou, Beiyan, Qi, Ling, Huertas-Vazquez, Adriana, Lusis, Aldons J., Xu, X.Z. Shawn, Li, Siming, Yu, Yonghao, Li, Jun Z., Lin, Jiandie D.

“…Cell-cell communication via ligand-receptor signaling is a fundamental feature of complex organs. Despite this, the global landscape of intercellular signaling…”
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Alternative Splicing Regulatory Networks: Functions, Mechanisms, and Evolution by Ule, Jernej, Blencowe, Benjamin J.

“…High-throughput sequencing-based methods and their applications in the study of transcriptomes have revolutionized our understanding of alternative splicing…”
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A conceptual framework for understanding phase separation and addressing open questions and challenges by Mittag, Tanja, Pappu, Rohit V.

“…Macromolecular phase separation is being recognized for its potential importance and relevance as a driver of spatial organization within cells. Here, we…”
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Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis by Legnini, Ivano, Di Timoteo, Gaia, Rossi, Francesca, Morlando, Mariangela, Briganti, Francesca, Sthandier, Olga, Fatica, Alessandro, Santini, Tiziana, Andronache, Adrian, Wade, Mark, Laneve, Pietro, Rajewsky, Nikolaus, Bozzoni, Irene

“…Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a…”
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How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms by Corley, Meredith, Burns, Margaret C., Yeo, Gene W.

“…RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures…”
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Integrated lncRNA function upon genomic and epigenomic regulation by Herman, Allison B., Tsitsipatis, Dimitrios, Gorospe, Myriam

“…Although some long noncoding (lnc)RNAs are known since the 1950s, the past 25 years have uncovered myriad lncRNAs with diverse sequences, structures, and…”
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AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance by Garcia, Daniel, Shaw, Reuben J.

“…AMPK is a highly conserved master regulator of metabolism, which restores energy balance during metabolic stress both at the cellular and physiological levels…”
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ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response by Blackford, Andrew N., Jackson, Stephen P.

“…In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the…”
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Translation of CircRNAs by Pamudurti, Nagarjuna Reddy, Bartok, Osnat, Jens, Marvin, Ashwal-Fluss, Reut, Stottmeister, Christin, Ruhe, Larissa, Hanan, Mor, Wyler, Emanuel, Perez-Hernandez, Daniel, Ramberger, Evelyn, Shenzis, Shlomo, Samson, Moshe, Dittmar, Gunnar, Landthaler, Markus, Chekulaeva, Marina, Rajewsky, Nikolaus, Kadener, Sebastian

“…Circular RNAs (circRNAs) are abundant and evolutionarily conserved RNAs of largely unknown function. Here, we show that a subset of circRNAs is translated…”
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Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death by Cobine, Paul A, Brady, Donita C

“…Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme…”
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