Search Results - "Molecular cancer"

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives by Mao, Xiaoqi, Xu, Jin, Wang, Wei, Liang, Chen, Hua, Jie, Liu, Jiang, Zhang, Bo, Meng, Qingcai, Yu, Xianjun, Shi, Si

“…Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components…”
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Combination strategies with PD-1/PD-L1 blockade: current advances and future directions by Yi, Ming, Zheng, Xiaoli, Niu, Mengke, Zhu, Shuangli, Ge, Hong, Wu, Kongming

“…Antibodies targeting programmed cell death protein-1 (PD-1) or its ligand PD-L1 rescue T cells from exhausted status and revive immune response against cancer…”
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Ferroptosis in cancer therapy: a novel approach to reversing drug resistance by Zhang, Chen, Liu, Xinyin, Jin, Shidai, Chen, Yi, Guo, Renhua

“…Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from apoptosis, necrosis, and autophagy. Extensive studies suggest that…”
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Autophagy and autophagy-related proteins in cancer by Li, Xiaohua, He, Shikun, Ma, Binyun

“…Autophagy, as a type II programmed cell death, plays crucial roles with autophagy-related (ATG) proteins in cancer. Up to now, the dual role of autophagy both…”
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Role of hypoxia in cancer therapy by regulating the tumor microenvironment by Jing, Xinming, Yang, Fengming, Shao, Chuchu, Wei, Ke, Xie, Mengyan, Shen, Hua, Shu, Yongqian

“…Clinical resistance is a complex phenomenon in major human cancers involving multifactorial mechanisms, and hypoxia is one of the key components that affect…”
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Circular RNA: metabolism, functions and interactions with proteins by Zhou, Wei-Yi, Cai, Ze-Rong, Liu, Jia, Wang, De-Shen, Ju, Huai-Qiang, Xu, Rui-Hua

“…Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals. Important…”
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PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer by Glaviano, Antonino, Foo, Aaron S C, Lam, Hiu Y, Yap, Kenneth C H, Jacot, William, Jones, Robert H, Eng, Huiyan, Nair, Madhumathy G, Makvandi, Pooyan, Geoerger, Birgit, Kulke, Matthew H, Baird, Richard D, Prabhu, Jyothi S, Carbone, Daniela, Pecoraro, Camilla, Teh, Daniel B L, Sethi, Gautam, Cavalieri, Vincenzo, Lin, Kevin H, Javidi-Sharifi, Nathalie R, Toska, Eneda, Davids, Matthew S, Brown, Jennifer R, Diana, Patrizia, Stebbing, Justin, Fruman, David A, Kumar, Alan P

“…The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal transduction network in eukaryotic cells that promotes cell survival, cell growth, and…”
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Targeting TGF-β signal transduction for fibrosis and cancer therapy by Peng, Dandan, Fu, Minyang, Wang, Manni, Wei, Yuquan, Wei, Xiawei

“…Transforming growth factor β (TGF-β) has long been identified with its intensive involvement in early embryonic development and organogenesis, immune…”
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Functions of N6-methyladenosine and its role in cancer by He, Liuer, Li, Huiyu, Wu, Anqi, Peng, Yulong, Shu, Guang, Yin, Gang

“…N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA…”
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mRNA vaccine for cancer immunotherapy by Miao, Lei, Zhang, Yu, Huang, Leaf

“…mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor…”
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Lung cancer immunotherapy: progress, pitfalls, and promises by Lahiri, Aritraa, Maji, Avik, Potdar, Pravin D, Singh, Navneet, Parikh, Purvish, Bisht, Bharti, Mukherjee, Anubhab, Paul, Manash K

“…Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery,…”
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Wnt signaling in colorectal cancer: pathogenic role and therapeutic target by Zhao, Hui, Ming, Tianqi, Tang, Shun, Ren, Shan, Yang, Han, Liu, Maolun, Tao, Qiu, Xu, Haibo

“…Abstract Background The Wnt signaling pathway is a complex network of protein interactions that functions most commonly in embryonic development and cancer,…”
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The cancer metabolic reprogramming and immune response by Xia, Longzheng, Oyang, Linda, Lin, Jinguan, Tan, Shiming, Han, Yaqian, Wu, Nayiyuan, Yi, Pin, Tang, Lu, Pan, Qing, Rao, Shan, Liang, Jiaxin, Tang, Yanyan, Su, Min, Luo, Xia, Yang, Yiqing, Shi, Yingrui, Wang, Hui, Zhou, Yujuan, Liao, Qianjin

“…The overlapping metabolic reprogramming of cancer and immune cells is a putative determinant of the antitumor immune response in cancer. Increased evidence…”
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Glioma targeted therapy: insight into future of molecular approaches by Yang, Keyang, Wu, Zhijing, Zhang, Hao, Zhang, Nan, Wu, Wantao, Wang, Zeyu, Dai, Ziyu, Zhang, Xun, Zhang, Liyang, Peng, Yun, Ye, Weijie, Zeng, Wenjing, Liu, Zhixiong, Cheng, Quan

“…Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically, gliomas occur among all ages, more often seen in adults, which…”
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Exosomes as a new frontier of cancer liquid biopsy by Yu, Dan, Li, Yixin, Wang, Maoye, Gu, Jianmei, Xu, Wenrong, Cai, Hui, Fang, Xinjian, Zhang, Xu

“…Liquid biopsy, characterized by minimally invasive detection through biofluids such as blood, saliva, and urine, has emerged as a revolutionary strategy for…”
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Targeting STAT3 in Cancer Immunotherapy by Zou, Sailan, Tong, Qiyu, Liu, Bowen, Huang, Wei, Tian, Yan, Fu, Xianghui

“…Abstract As a point of convergence for numerous oncogenic signaling pathways, signal transducer and activator of transcription 3 (STAT3) is central in…”
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m6A regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in gastric cancer by Zhang, Bo, Wu, Qiong, Li, Ben, Wang, Defeng, Wang, Lei, Zhou, You Lang

“…Abstract Background The epigenetic regulation of immune response has been demonstrated in recent studies. Nonetheless, potential roles of RNA…”
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The potential role of RNA N6-methyladenosine in Cancer progression by Wang, Tianyi, Kong, Shan, Tao, Mei, Ju, Shaoqing

“…N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA…”
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Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4 by Qin, Shuang, Xu, Linping, Yi, Ming, Yu, Shengnan, Wu, Kongming, Luo, Suxia

“…The emergence of immune checkpoint inhibitors (ICIs), mainly including anti-programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) and…”
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CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer by Zhang, Haiyang, Deng, Ting, Liu, Rui, Ning, Tao, Yang, Haiou, Liu, Dongying, Zhang, Qiumo, Lin, Dan, Ge, Shaohua, Bai, Ming, Wang, Xinyi, Zhang, Le, Li, Hongli, Yang, Yuchong, Ji, Zhi, Wang, Hailong, Ying, Guoguang, Ba, Yi

“…Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated…”
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