Search Results - "Molecular autism"

Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses by Modabbernia, Amirhossein, Velthorst, Eva, Reichenberg, Abraham

“…According to recent evidence, up to 40-50% of variance in autism spectrum disorder (ASD) liability might be determined by environmental factors. In the present…”
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Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia by The Psychiatric Genomics Consortium, The Autism Spectrum Disorders Working Group Of, Anney, Richard J L, Ripke, Stephan, Anttila, Verneri, Grove, Jakob, Holmans, Peter, Huang, Hailiang, Klei, Lambertus, Lee, Phil H, Medland, Sarah E, Neale, Benjamin, Robinson, Elise, Weiss, Lauren A, Zwaigenbaum, Lonnie, Yu, Timothy W, Wittemeyer, Kerstin, Willsey, a Jeremy, Wijsman, Ellen M, Werge, Thomas, Wassink, Thomas H, Waltes, Regina, Walsh, Christopher A, Wallace, Simon, Vorstman, Jacob a S, Vieland, Veronica J, Vicente, Astrid M, Vanengeland, Herman, Tsang, Kathryn, Thompson, Ann P, Szatmari, Peter, Svantesson, Oscar, Steinberg, Stacy, Stefansson, Kari, Stefansson, Hreinn, State, Matthew W, Soorya, Latha, Silagadze, Teimuraz, Scherer, Stephen W, Schellenberg, Gerard D, Sandin, Sven, Sanders, Stephan J, Saemundsen, Evald, Rouleau, Guy A, Rogé, Bernadette, Roeder, Kathryn, Roberts, Wendy, Reichert, Jennifer, Reichenberg, Abraham, Rehnström, Karola, Regan, Regina, Poustka, Fritz, Poultney, Christopher S, Piven, Joseph, Pinto, Dalila, Pericak-Vance, Margaret A, Pejovic-Milovancevic, Milica, Pedersen, Marianne Giørtz, Pedersen, Carsten Bøcker, Paterson, Andrew D, Parr, Jeremy R, Pagnamenta, Alistair T, Oliveira, Guiomar, Nurnberger, John I, Nordentoft, Merete, Murtha, Michael T, Mouga, Susana, Mortensen, Preben Bo, Mors, Ole, Morrow, Eric M, Moreno-De-Luca, Daniel, Monaco, Anthony P, Minshew, Nancy, Merikangas, Alison, Mcmahon, William M, Mcgrew, Susan G, Mattheisen, Manuel, Martsenkovsky, Igor, Martin, Donna M, Mane, Shrikant M, Magnusson, Pall, Magalhaes, Tiago, Maestrini, Elena, Lowe, Jennifer K, Lord, Catherine, Levitt, Pat, Martin, Christa Lese, Ledbetter, David H, Leboyer, Marion, Lecouteur, Ann S, Ladd-Acosta, Christine, Kolevzon, Alexander, Klauck, Sabine M, Jacob, Suma, Iliadou, Bozenna, Hultman, Christina M, Hougaard, David M, Hertz-Picciotto, Irva, Hendren, Robert, Hansen, Christine Søholm, Haines, Jonathan L

“…Over the past decade genome-wide association studies (GWAS) have been applied to aid in the understanding of the biology of traits. The success of this…”
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Coping, fostering resilience, and driving care innovation for autistic people and their families during the COVID-19 pandemic and beyond by Ameis, Stephanie H, Lai, Meng-Chuan, Mulsant, Benoit H, Szatmari, Peter

“…The new coronavirus disease (COVID-19) pandemic is changing how society operates. Environmental changes, disrupted routines, and reduced access to services and…”
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Selection bias on intellectual ability in autism research: a cross-sectional review and meta-analysis by Russell, Ginny, Mandy, William, Elliott, Daisy, White, Rhianna, Pittwood, Tom, Ford, Tamsin

“…Current global estimates suggest the proportion of the population with autism spectrum disorder (ASD) who have intellectual disability (ID) is approximately…”
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Autism prevalence in China is comparable to Western prevalence by Sun, Xiang, Allison, Carrie, Wei, Liping, Matthews, Fiona E, Auyeung, Bonnie, Wu, Yu Yu, Griffiths, Sian, Zhang, Jie, Baron-Cohen, Simon, Brayne, Carol

“…Autism prevalence in the West is approximately 1% of school age children. Autism prevalence in China has been reported to be lower than in the West. This is…”
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Is social camouflaging associated with anxiety and depression in autistic adults? by Hull, Laura, Levy, Lily, Lai, Meng-Chuan, Petrides, K V, Baron-Cohen, Simon, Allison, Carrie, Smith, Paula, Mandy, Will

“…There is inconsistent evidence for a clear pattern of association between 'camouflaging' (strategies used to mask and/or compensate for autism characteristics…”
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Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology by Cheroni, Cristina, Caporale, Nicolò, Testa, Giuseppe

“…Abstract The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds…”
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Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders by Fiorentino, Maria, Sapone, Anna, Senger, Stefania, Camhi, Stephanie S, Kadzielski, Sarah M, Buie, Timothy M, Kelly, Deanna L, Cascella, Nicola, Fasano, Alessio

“…Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive…”
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Sex and gender differences in autism spectrum disorder: summarizing evidence gaps and identifying emerging areas of priority by Halladay, Alycia K, Bishop, Somer, Constantino, John N, Daniels, Amy M, Koenig, Katheen, Palmer, Kate, Messinger, Daniel, Pelphrey, Kevin, Sanders, Stephan J, Singer, Alison Tepper, Taylor, Julie Lounds, Szatmari, Peter

“…One of the most consistent findings in autism spectrum disorder (ASD) research is a higher rate of ASD diagnosis in males than females. Despite this,…”
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The psychological impact of the COVID-19 pandemic on adults with autism: a survey study across three countries by Oomen, Danna, Nijhof, Annabel D, Wiersema, Jan R

“…Previous studies have reported a negative psychological and mental health impact of the COVID-19 pandemic. This impact is likely to be stronger for people with…”
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SFARI Gene 2.0: a community-driven knowledgebase for the autism spectrum disorders (ASDs) by Abrahams, Brett S, Arking, Dan E, Campbell, Daniel B, Mefford, Heather C, Morrow, Eric M, Weiss, Lauren A, Menashe, Idan, Wadkins, Tim, Banerjee-Basu, Sharmila, Packer, Alan

“…New technologies enabling genome-wide interrogation have led to a large and rapidly growing number of autism spectrum disorder (ASD) candidate genes. Although…”
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Cannabinoid treatment for autism: a proof-of-concept randomized trial by Aran, Adi, Harel, Moria, Cassuto, Hanoch, Polyansky, Lola, Schnapp, Aviad, Wattad, Nadia, Shmueli, Dorit, Golan, Daphna, Castellanos, F Xavier

“…Endocannabinoid dysfunction in animal models of autism spectrum disorder (ASD) and accumulating, albeit anecdotal, evidence for efficacy in humans motivated…”
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CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells by Wang, Ping, Mokhtari, Ryan, Pedrosa, Erika, Kirschenbaum, Michael, Bayrak, Can, Zheng, Deyou, Lachman, Herbert M

“…(chromodomain helicase DNA-binding protein 8), which codes for a member of the CHD family of ATP-dependent chromatin-remodeling factors, is one of the most…”
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Ketogenic diet modifies the gut microbiota in a murine model of autism spectrum disorder by Newell, Christopher, Bomhof, Marc R, Reimer, Raylene A, Hittel, Dustin S, Rho, Jong M, Shearer, Jane

“…Gastrointestinal dysfunction and gut microbial composition disturbances have been widely reported in autism spectrum disorder (ASD). This study examines…”
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The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders by Loth, Eva, Charman, Tony, Mason, Luke, Tillmann, Julian, Jones, Emily J H, Wooldridge, Caroline, Ahmad, Jumana, Auyeung, Bonnie, Brogna, Claudia, Ambrosino, Sara, Banaschewski, Tobias, Baron-Cohen, Simon, Baumeister, Sarah, Beckmann, Christian, Brammer, Michael, Brandeis, Daniel, Bölte, Sven, Bourgeron, Thomas, Bours, Carsten, de Bruijn, Yvette, Chakrabarti, Bhismadev, Crawley, Daisy, Cornelissen, Ineke, Acqua, Flavio Dell', Dumas, Guillaume, Durston, Sarah, Ecker, Christine, Faulkner, Jessica, Frouin, Vincent, Garces, Pilar, Goyard, David, Hayward, Hannah, Ham, Lindsay M, Hipp, Joerg, Holt, Rosemary J, Johnson, Mark H, Isaksson, Johan, Kundu, Prantik, Lai, Meng-Chuan, D'ardhuy, Xavier Liogier, Lombardo, Michael V, Lythgoe, David J, Mandl, René, Meyer-Lindenberg, Andreas, Moessnang, Carolin, Mueller, Nico, O'Dwyer, Laurence, Oldehinkel, Marianne, Oranje, Bob, Pandina, Gahan, Persico, Antonio M, Ruigrok, Amber N V, Ruggeri, Barbara, Sabet, Jessica, Sacco, Roberto, Cáceres, Antonia San José, Simonoff, Emily, Toro, Roberto, Tost, Heike, Waldman, Jack, Williams, Steve C R, Zwiers, Marcel P, Spooren, Will, Murphy, Declan G M, Buitelaar, Jan K

“…The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new…”
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Measuring autistic traits in the general population: a systematic review of the Autism-Spectrum Quotient (AQ) in a nonclinical population sample of 6,900 typical adult males and females by Ruzich, Emily, Allison, Carrie, Smith, Paula, Watson, Peter, Auyeung, Bonnie, Ring, Howard, Baron-Cohen, Simon

“…The Autism-Spectrum Quotient (AQ) is a self-report measure of autistic traits. It is frequently cited in diverse fields and has been administered to adults of…”
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Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice by Perets, Nisim, Hertz, Stav, London, Michael, Offen, Daniel

“…Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by three core symptoms that include social interaction deficits, cognitive…”
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An investigation of the 'female camouflage effect' in autism using a computerized ADOS-2 and a test of sex/gender differences by Rynkiewicz, Agnieszka, Schuller, Björn, Marchi, Erik, Piana, Stefano, Camurri, Antonio, Lassalle, Amandine, Baron-Cohen, Simon

“…Autism spectrum conditions (autism) are diagnosed more frequently in boys than in girls. Females with autism may have been under-identified due to not only a…”
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Delineation of the genetic and clinical spectrum of Phelan-McDermid syndrome caused by SHANK3 point mutations by De Rubeis, Silvia, Siper, Paige M, Durkin, Allison, Weissman, Jordana, Muratet, François, Halpern, Danielle, Trelles, Maria Del Pilar, Frank, Yitzchak, Lozano, Reymundo, Wang, A Ting, Holder, Jr, J Lloyd, Betancur, Catalina, Buxbaum, Joseph D, Kolevzon, Alexander

“…Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder characterized by psychiatric and neurological features. Most reported cases are caused by…”
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Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism by Gevi, Federica, Zolla, Lello, Gabriele, Stefano, Persico, Antonio M

“…Autism spectrum disorder (ASD) is still diagnosed through behavioral observation, due to a lack of laboratory biomarkers, which could greatly aid clinicians in…”
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